However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:In this study, we investigated that the histopathological changes of rat kidney and liver tissuesafter cisplatin administration and potential beneficial effects of morin and hesperidinadministration.
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Temel Bulgular & Veri:Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin(H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H),cisplatin+morin+hesperidin (CP+M+H).
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Sonuç & Katkı:However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Abstract
In this study, we investigated that the histopathological changes of rat kidney and liver tissuesafter cisplatin administration and potential beneficial effects of morin and hesperidinadministration. Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin(H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H),cisplatin+morin+hesperidin (CP+M+H). Kidney and liver tissues were collected at the end ofthe experiment and were evaluated histopathological changes. Various histopathologicalchanges in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.
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Bu Makaleye Atıf Yap
KALTALIOĞLU, K., CEVHER, Ş. C., BALABANLI, B., APAYDIN, F. G. (2022). Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science, Cilt: 31 - Sayı: 2, 399–406. https://ajindex.com/articles/521392
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