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Dergiler / Gazi University Journal of Science / 2026 / Volume: 39 Issue: 3

Hydrothermal synthesis of silver vanadate nanoparticles, antimicrobial and anti-inflammatory potentials, cytotoxicity and interference on the activity of antimicrobial drugs

Juliane Zacour Marinho(State University of Campinas)0000-0002-7865-9409
Luiz Felipe Carreiro Machado(Anhanguera College)0000-0002-7474-7452
Isabela Pena Ceravolo(Rene Rachou Institute, Oswaldo Cruz Foundation)0000-0002-1374-2703
Lucas Leão Nascimento(Federal University of Uberlândia)0000-0002-7777-2864
Antonio Otavio De Toledo Patrocínio(Federal University of Uberlândia)0000-0003-3141-3214
Marcus Vinícius Dias Souza(Anhanguera College)0000-0001-5723-5095
Sayfa
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Yayın Tarihi
2026-09-01
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Our findings suggest that SVM is a promising candidate for combination therapy, warranting further investigation with surface-functionalized formulations to improve its selectivity.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Bacterial resistance to antimicrobial drugs represents a critical threat to global health, compromising the efficacy of standard therapies.
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Temel Bulgular & Veri:SVMs were active against all tested isolates, with MIC values of 128 µg/mL for S. aureus and 256 µg/mL for Gram-negative species.
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Sonuç & Katkı:Our findings suggest that SVM is a promising candidate for combination therapy, warranting further investigation with surface-functionalized formulations to improve its selectivity.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Silver vanadate · Nanoparticles · Antimicrobial

Abstract

Bacterial resistance to antimicrobial drugs represents a critical threat to global health, compromising the efficacy of standard therapies. In this study, we evaluated the antimicrobial properties of silver vanadate microrods (SVMs) against clinical isolates of Staphylococcus aureus, Escherichia coli , and Pseudomonas aeruginosa . SVMs were active against all tested isolates, with MIC values of 128 µg/mL for S. aureus and 256 µg/mL for Gram-negative species. Notably, checkerboard assays revealed synergistic interactions with azithromycin, clindamycin, and sulfamethoxazole (FICi 0.093-0.125), indicating that SVM might potentiate the activity of antimicrobial drugs. The MBC/MIC ratio classified SVM as bactericidal against Gram-negative isolates and bacteriostatic against S. aureus . Scanning electron microscopy suggested a membrane disruption mechanism by a direct nanoparticle-bacteria interaction. SVM also exhibited anti-inflammatory activity comparable to tenoxicam in vitro. SVM presented cytotoxicity to BGM cells at 3.13 µg/mL (CC 50 ). Our findings suggest that SVM is a promising candidate for combination therapy, warranting further investigation with surface-functionalized formulations to improve its selectivity.

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Bu Makaleye Atıf Yap

Marinho, J. Z., Machado, L. F. C., Ceravolo, I. P., Nascimento, L. L., Patrocínio, A. O. D. T., Souza, M. V. D. (2026). Hydrothermal synthesis of silver vanadate nanoparticles, antimicrobial and anti-inflammatory potentials, cytotoxicity and interference on the activity of antimicrobial drugs. Gazi University Journal of Science, Volume: 39 Issue: 3. https://doi.org/10.35378/gujs.1873395

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