However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.
📌 3 Key Takeaways
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Objective & Hypothesis:In this study, we investigated that the histopathological changes of rat kidney and liver tissuesafter cisplatin administration and potential beneficial effects of morin and hesperidinadministration.
Conclusion & Impact:However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
In this study, we investigated that the histopathological changes of rat kidney and liver tissuesafter cisplatin administration and potential beneficial effects of morin and hesperidinadministration. Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin(H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H),cisplatin+morin+hesperidin (CP+M+H). Kidney and liver tissues were collected at the end ofthe experiment and were evaluated histopathological changes. Various histopathologicalchanges in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.
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Cite This Article
KALTALIOĞLU, K., CEVHER, Ş. C., BALABANLI, B., APAYDIN, F. G. (2022). Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science, Cilt: 31 - Sayı: 2, 399–406. https://ajindex.com/articles/521392
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