PL fruit extracts can restore the oxidative changes caused by paracetamol.
📌 3 Key Takeaways
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Objective & Hypothesis:Paracetamol is a popular analgesic drug and its overdose may cause toxicity in the kidney.
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Key Findings & Data:For this purpose, 30 rats were divided into 5 groups: control, negative control (2 g/kg paracetamol), PL fruit water extract (400 mg/kg PLW+ 2 g/kg paracetamol), PL fruit ethanol-water extract (400 mg/kg PLEW+ 2 g/kg paracetamol) and positive control (150 mg/kg NAC+ 2 g/kg paracetamol). 24 hours after the paracetamol induction, animals were sacrificed and oxidative parameters were analyzed spectrophotometrically in kidney tissue.
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Conclusion & Impact:PL fruit extracts can restore the oxidative changes caused by paracetamol.
Paracetamol is a popular analgesic drug and its overdose may cause toxicity in the kidney. Prunus laurocerasus L. (PL) is an important folklore medicinal plant that has antioxidant properties. This study explores effects of PL fruit water and ethanol-water extracts administrations on oxidative stress in paracetamol-induced nephrotoxicity. For this purpose, 30 rats were divided into 5 groups: control, negative control (2 g/kg paracetamol), PL fruit water extract (400 mg/kg PLW+ 2 g/kg paracetamol), PL fruit ethanol-water extract (400 mg/kg PLEW+ 2 g/kg paracetamol) and positive control (150 mg/kg NAC+ 2 g/kg paracetamol). 24 hours after the paracetamol induction, animals were sacrificed and oxidative parameters were analyzed spectrophotometrically in kidney tissue. PLW and PLEW extracts decreased MDA and NOx levels and increased SOD and CAT activities in paracetamol-induced nephrotoxicity. PL fruit extracts can restore the oxidative changes caused by paracetamol.
Karabağ Çoban F, Kuru B. Effect of boron on trace element level and oxidative stress in paracetamol induced hepatotoxicity model. Journal of Boron 4 (2019) 92–99.
Ferah I, Halici Z, Bayir Y, Demirci E, Unal B, Cadirci E. The role of infliximab on paracetamol-induced hepatotoxicity in rats. Immunopharmacology and Immunotoxicology 35 (2013) 373–381.
Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, Reisch JS, Schiødt FV, Ostapowicz G, Shakil AO, Lee WM. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 42 (2005) 1364–1372.
Ozkaya O, Genc G, Bek K, Sullu Y. A case of acetaminophen (paracetamol) causing renal failure without liver damage in a child and review of literature. Renal Failure 32 (2010) 1125–1127.
Boutis K, Shannon M. Nephrotoxicity after acute severe acetaminophen poisoning in adolescents. Clinical Toxicology 39 (2001) 441–445.
Hung OL, Nelson LS. Acetaminophen, in: Tintinalli JE, Kelen GD, Stapczynski JS (Eds.) Tintinalli’s emergency medicine: a comprehensive study guide. 6th ed. McGraw-Hill, New York, pp. 1088–1094, 2004.
Canayakin D, Bayir Y, Kilic Baygutalp N, Sezen Karaoglan E, Atmaca HT, Kocak Ozgeris FB, Keles MS, Halici Z. Paracetamol-induced nephrotoxicity and oxidative stress in rats: the protective role of Nigella sativa. Pharmaceutical Biology 54 (2016) 2082–2091.
Macherey AC, Dansette, PM. Biotransformations Leading to Toxic Metabolites: Chemical Aspects, in: Wermuth CG, Aldous D, Raboisson P, Rognan D (Eds.) The Practice of Medicinal Chemistry. 4th ed. Academic Press, pp. 585–614, 2015. Tejo J. Curcumin, antioxidant activity, and paracetamol toxicity, in: Vinood BP, Victor RP (Eds.) Toxicology. Academic Press, pp. 467–477, 2021.
Li J, Chiew AL, Isbister GK, Duffull, SB. Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose. British journal of clinical pharmacology 87 (2021) 2392–2396.
Bessems JG, Vermeulen NP. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Critical Reviews in Toxicology 31 (2001) 55–138.
Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, Sergio FN. Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radical Research 52 (2018) 751-762.