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Dergiler / Hittite Journal of Science and Engineering / 2020 / Cilt: 7 - Sayı: 1

Some Serum Oxidative Parameters in Normoglycemic Rats: Vascular Endothelial Growth Factor (VEGF) Application

Şule COŞKUN CEVHER
Kaan KALTALIOĞLU
Sayfa
55–59
Yayın Tarihi
2022-10-18
DOI
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Results werecompared by one-way ANOVA (p

📌 3 Maddede Bu Makale

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Amaç & Hipotez:VEGF has the positive effect on wound healing.
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Temel Bulgular & Veri:In this study, the effect of VEGF application on some serum parameters during wound healing process were investigated. 36female normoglycemic Wistar rats were used (200–250 g).
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Sonuç & Katkı:Results werecompared by one-way ANOVA (p
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

VEGF has the positive effect on wound healing. In this study, the effect of VEGF application on some serum parameters during wound healing process were investigated. 36female normoglycemic Wistar rats were used (200–250 g). Dorsolateral incisional wounds(length: 4 cm) were made on the two sides of the medulla spinalis in rats. They were divided into 3 groups: untreated group (n=12), chitosan group (n=12) and chitosan+VEGFgroup (n=12). The rats were sacrificed on the 3rd and 7th days of post wounding. NOx,TBARs and RSH levels were determined spectrophotometrically in serum. Results werecompared by one-way ANOVA (p

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Bu Makaleye Atıf Yap

CEVHER, Ş. C., KALTALIOĞLU, K. (2022). Some Serum Oxidative Parameters in Normoglycemic Rats: Vascular Endothelial Growth Factor (VEGF) Application. Hittite Journal of Science and Engineering, Cilt: 7 - Sayı: 1, 55–59. https://ajindex.com/articles/537933

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Kaynakça (15)

  1. Harding KG, Morris HL, Patel GK. Science, medicine and the future: Healing chronic wounds. BMJ 324 (2002) 160-163
  2. Fahey TJ, Sadaty A, Jones WG, Barbe A, Smoller B, Shires GT. Diabetes impairs the late inflammatory response to wound healing. J Surg Res 50 (1991) 308-313
  3. Lerman OZ, Galiano RD, Armour M, Levine JD, Gurtner, GC. Cellular dysfunction in the diabetic fibroblast. Am J Pathol 162 (2003) 303-312
  4. Komesu MC, Tanga MB, Buttros KR, Nakao C. Effects of acute diabetes on rat cutaneous wound healing. Pathophysiology 11 (2004) 63-67
  5. Lobmann R, Ambrosch A, Schultz G, Waldmann K, Schiweck S, Lehnert H. Expression of matrix-metalloproteinases and their inhibitors in the wound of diabetic and non-diabetic patients. Diabetologia 45 (2002) 1011-1016
  6. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669–676
  7. Poltorak Z, Cohen T, Neufeld G. The VEGF splice variants: properties, receptors, and usage for the treatment of ischemic diseases. Herz 25 (2000) 126–129
  8. Tammela T, Enholm B, Alitalo K, Paavonen K. The biology of vascular endothelial growth factors. Cardiovasc Res 65 (2005) 550–563
  9. Ferrara N, Davis-Smith T. The biology of vascular endothelial growth factor. Endocr Rev 18 (1997) 4–25
  10. Sun T, Yao Q, Zhou D, Mao F. Antioxidant activity of N-carboxymethyl chitosan oligosaccharides. Bioorg Med Chem Lett 18 (2008) 5774-5776
  11. Sen CK, Khanna S, Babior BM, Hunt TK, Ellison EC, Roy S. Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing. J Biol Chem 277 (2002) 33284-33290
  12. Aktunc E, Ozacmak VH, Ozacmak HS, Barut F, Buyukates M, Kandemir O, Demircan N. N-acetyl cysteine promotes angiogenesis and clearance of free oxygen radicals, thus improving wound healing in an alloxan-induced diabetic mouse model of incisional wound. Clin Exp Dermatol 35(2010) 902-909
  13. Roy S, Khanna S, Sen CK. Redox regulation of the VEGF signaling path and tissue vascularization: Hydrogen peroxide the common link between physical exercise and cutaneous wound healing. Free Radic Biol Med 44 (2008) 180-192
  14. Fraisl P. Crosstalk between oxygen- and nitric oxide-dependent signaling pathways in angiogenesis. Experimental Cell Research 319 (2013) 1331–1339
  15. İnan ZDŞ. Deneysel Diyabetli Sıçanlarda Kitozanın Yara İyileşmesine Etkisinin İncelenmesi. Yüksek Lisans Tezi. HistolojiEmbriyoloji AbD. Sivas Cumhuriyet Üniversitesi Fen/Sağlık Bilimleri Enstitüs