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Dergiler / Hittite Journal of Science and Engineering / 2026 / Volume: 13 Issue: 3

Design and Characterization of a Green-Synthesized Magnetic Hybrid 1 Material for Local Antibiotic Delivery in Periodontal Therapy

Design and Characterization of a Green-Synthesized Magnetic Hybrid Material for Local Antibiotic Delivery in Periodontal Therapy

Çiğdem Dönmez Güngüneş(Hitit Üniversitesi)0000-0003-3668-3697
Şahturna Demirtaş(HITIT UNIVERSITY)0009-0000-6996-712X
Sayfa
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Yayın Tarihi
2026-09-30
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bu bulgular, MC sisteminin periodontitisin lokalize ve etkili tedavisi için umut vadeden bir aday olduğunu göstermektedir.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Bu çalışma, periodontitis tedavisinde Tetrasiklin HCl'nin lokal iletimi için manyetik bir nanotaşıyıcı sistem geliştirmeye odaklanmaktadır. pH-15'e duyarlı özelliklere sahip manyetik nanopartiküller, hem kaplama hem de indirgeyici ajan olarak Camellia sinensis (yeşil çay) kullanılarak çevre dostu bir yöntemle sentezlendi.
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Temel Bulgular & Veri:FTIR, SEM ve Mössbauer spektroskopisi yöntemleri kullanılarak yapılan karakterizasyon çalışması, hibrit biyokompozitin başarılı bir şekilde sentezlendiğini ve ilacı taşımada etkili olduğunu ortaya koydu.
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Sonuç & Katkı:Bu bulgular, MC sisteminin periodontitisin lokalize ve etkili tedavisi için umut vadeden bir aday olduğunu göstermektedir.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Green synthesis · Camellia sinensis · Magnetic nanoparticles

Özet

Bu çalışma, periodontitis tedavisinde Tetrasiklin HCl'nin lokal iletimi için manyetik bir nanotaşıyıcı sistem geliştirmeye odaklanmaktadır. pH-15'e duyarlı özelliklere sahip manyetik nanopartiküller, hem kaplama hem de indirgeyici ajan olarak Camellia sinensis (yeşil çay) kullanılarak çevre dostu bir yöntemle sentezlendi. FTIR, SEM ve Mössbauer spektroskopisi yöntemleri kullanılarak yapılan karakterizasyon çalışması, hibrit biyokompozitin başarılı bir şekilde sentezlendiğini ve ilacı taşımada etkili olduğunu ortaya koydu. Manyetik C. sinensis nanopartikülleri (MCs NPs), %95,43'lük olağanüstü bir ilaç yükleme kapasitesiyle 41,157 m2/g'lık yüksek bir yüzey alanına sahiptir. İn vitro salım çalışmaları, ilacın fizyolojik pH'da (7,4) gün boyunca kontrollü ve sürekli bir şekilde salınabileceğini gösterdi. Enfekte periodontal bölgeyi temsil eden pH 6,25'te, MC'ler yaklaşık 8,6 saat içinde hızlı, pH-24'e duyarlı bir terapötik salınım profili sergiledi. Bu bulgular, MC sisteminin periodontitisin lokalize ve etkili tedavisi için umut vadeden bir aday olduğunu göstermektedir.

Abstract

This study focuses on developing a magnetic nanocarrier system for local delivery 14 of Tetracycline HCl to treat periodontitis. Magnetic nanoparticles with pH-15 responsive properties were synthesized using an environmentally friendly method 16 with Camellia sinensis (green tea) as both a capping and reducing agent. The 17 characterization study using FTIR, SEM, and Mössbauer spectroscopy methods 18 revealed that the hybrid biocomposite was successfully synthesized and effective at 19 carrying the drug. The Magnetic C. sinensis nanoparticles (MCs NPs) have a high 20 surface area of 41.157 m2/g with an exceptional drug loading capacity of 95.43%. 21 In vitro release studies showed that the drug could be released in a controlled and 22 continuous manner for 23 days at physiological pH (7.4). At pH 6,25, which 23 represents the infected periodontal region, the MCs demonstrated a rapid, pH-24 responsive therapeutic release profile in nearly 8,6 hours. These findings suggest 25 that the MCs system is a promising candidate for localized and effective treatment 26 of periodontitis.

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Bu Makaleye Atıf Yap

Güngüneş, Ç. D., Demirtaş, Ş. (2026). Design and Characterization of a Green-Synthesized Magnetic Hybrid 1 Material for Local Antibiotic Delivery in Periodontal Therapy. Hittite Journal of Science and Engineering, Volume: 13 Issue: 3. https://doi.org/10.17350/HJSE19030000385

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