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Dergiler / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2022 / Cilt: 12 - Sayı: 1

Association of DRD2 Gene C957T Polymorphism with Stuttering in Turkish Population

Fikriye POLAT
Ayşe AYDİN
Burcu YÜKSEL
Sayfa
124–132
Yayın Tarihi
2022-03-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

As a result, the polymorphic feature of the alleles and genotypes for the DRD2 gene C957T in Turkish children who stutter were analyzed, and it was detected that the differences between CWS and CWNS groups were not significant.Keywords: Stuttering, DRD2, rs6277, Turkish population

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Amaç & Hipotez:This study aims to evaluate the association of DRD2 gene C957T polymorphism with stuttering within Turkish children who stutter.
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Temel Bulgular & Veri:The sample of the study included 121 children between the ages of 5-16, 44 children with stuttering and 77 typically developing children.
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Sonuç & Katkı:As a result, the polymorphic feature of the alleles and genotypes for the DRD2 gene C957T in Turkish children who stutter were analyzed, and it was detected that the differences between CWS and CWNS groups were not significant.Keywords: Stuttering, DRD2, rs6277, Turkish population
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Stuttering · DRD2 · rs6277

Abstract

This study aims to evaluate the association of DRD2 gene C957T polymorphism with stuttering within Turkish children who stutter. The sample of the study included 121 children between the ages of 5-16, 44 children with stuttering and 77 typically developing children. The genomic DNA’s were extracted from the saliva of the individuals. The genotyping of DRD2 C957T was carried out using polymerase chain reaction-restriction fragment length polymorphism. The relationship between genotypes and stuttering was examined through logistic regression analysis. In the study, it was determined that distributions of allele frequencies and the DRD2 gene C957T polymorphism were not significantly different from the control group (OR 0.762; CI 0.458-1.267, p=0.304). The genotype distributions of the DRD2 gene were estimated for CT (OR 1.103; CI 0.443-2.743, p=0.833) and TT (OR 0.868; CI 0.306-2.461; P=0.791). The genotype distributions of DRD2 C957T polymorphism were not statistically significant for additive, dominant, recessive, and codominant models between study groups. As a result, the polymorphic feature of the alleles and genotypes for the DRD2 gene C957T in Turkish children who stutter were analyzed, and it was detected that the differences between CWS and CWNS groups were not significant.Keywords: Stuttering, DRD2, rs6277, Turkish population

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Bu Makaleye Atıf Yap

POLAT, F., AYDİN, A., YÜKSEL, B. (2022). Association of DRD2 Gene C957T Polymorphism with Stuttering in Turkish Population. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 12 - Sayı: 1, 124–132. https://ajindex.com/articles/382649

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Kaynakça (8)

  1. Alm PA, 2004. Stuttering and the Basal Ganglia Circuits: a Critical Review of Possible Relations. Journal of Communication Disorders, 37:325–369. Alm PA, 2005. On the Causal Mechanisms of Stuttering. Lund University http://theses.lub.lu.se/postgrad/ (Printed) Brady JP, 1991. The Pharmacology of Stuttering: A Critical Review. The American Journal of Psychiatry, 148(10):1309-16.
  2. Craig A, Hancock K, Tran Y, Craig M, Peters K, 2002. Epidemiology of Stuttering in The Community Across The Entire Life Span. Journal of Speech, Language and Hearing Research, 45(6):1097-1105.
  3. Domingues CE, Olivera CM, Oliveira BV, Juste FS, Andrade CR, Giacheti CM, Moretti-Ferreira D, Drayna D, 2014. A Genetic Linkage Study in Brazil Identifies a New Locus for Persistent Developmental Stuttering on Chromosome 10. Genetics and Molecular Research, 24;13(1):2094-2101
  4. Dworzynski K, Remington A, Rijsdijk F, Howell P, Plomin R, 2007. Genetic Etiology in Cases of Recovered and Persistent Stuttering in an Unselected, Longitudinal Sample of Young Twins. Amrican Journal of Speech-Language Pathology, 16:169-178.
  5. Fagnani C, Fibiger S, Skytthe A, Hjelmborg JV, 2011. Heritability and Environmental Effects for Self-Reported Periods with Stuttering: A Twin Study from Denmark. Logopedics, Phoniatrics Vocology, 36(3):114-120.
  6. Felsenfeld S, Kirk KM, Zhu G, Statham DJ, Neale MC et al., 2000. A Study of The Genetic and Environmental Etiology of Stuttering in a Selected Twin Sample. Behavior Genetics, 30:359–366.
  7. Felsenfeld S, Plomin R, 1997. Epidemiological and Offspring Analyses of Developmental Speech Disorders Using Data from the Colorado Adoption Project. Journal of Speech, Language and Hearing Research, 40:778-91. Guitar B, 2006. Stuttering: An Integrated Approach to Its Nature and Treatment (3th ed.). Lippincott Williams and Wilkins Philadelphia, PA. Hirvonen M, Laakso A, Nagren K, Rinne JO, Pohjalainen T, Hietala J, 2004. C957T Polymorphism of the Dopamine D2 Receptor (DRD2) Gene Affects Striatal DRD2 Availability in Vivo. Molecular Psychiatry, 9: 1060–1061. Howie PM, 1981. Concordance for Stuttering in Monozygotic and Dizygotic Twin Pairs. Journal of Speech, Language and Hearing Research, 24:317-321.
  8. Kang C, Domingues BS, Sainz E, Domingues CE, Drayna D, et al., 2011. Evaluation of the Association Between Polymorphisms at The DRD2 Locus and Stuttering. Journal of Human Genetics, 56(6):472-3. Kraft SJ, 2010. Genome-wide association study of persistent developmental stuttering. Doctora thesis. Uni