Effect Of Domperidon On Gastric Emptying İn Diabetic Patients With Gastroparesis

Abstract

The effect of Domperidon on gastric emptying time in 20 diabetic patients with gastropa¬resis was evaluated and compared to a control group consisting of 10 patients. In the control group; none of the patients had any gastrointestinal symptoms and their barium roentgenograms were normal. Preliminary to our study all patients have been evaluated using radiology, endoscopy and dynamic scintigraphic examination. After this evaluation domperidon (molitium) (eczacıbaşı) has been started 4x10 mg daily. Two weeks after the radioisotopic baseline study and under domperidon medication, the patients were questio¬ned about their symptoms and the gastric emptying times were restudied employing the same protocol. In conclusion, it is found that domperidon treatment in diabetic patients with gastroparesis is effective symptomatically and shortens significantly the gastric emp¬tying time without any side effects. Diyabetik gastroparetik hastalarda domperidon'un mide boşalma zamanına etkisi araştırıldı. Çalışma 20 diyabetik hasta üzerinden yapıldı. Endoskopik, radyolojik ve sintig-rafik çalışma ile diyabetik gastroparezis tanımlanmış hastalarda domperidon (Moülium-Eczacıbaşı) 40 mg/gün dozda başlandı. 15 gün süre ile hastalar yan etki, semptomatik iyileşme yönünden gözlendi. 15. gün sintigrafik olarak mide boşalma zamanı yinelendi. Sonuç olarak; diyabetik gastroparezis'li hastalarda uzamış mide boşalma zamanının dom¬peridon ile normale döndüğü ve ilaca bağlı yan etki gözlenmediği, hastalarda semptomatik iyileşme sağlandığı tespit edildi.