Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightGuideline-recommended HCC screening in these patients results in earlier diagnosis and increases both the likelihood of receiving curative treatment and overall survival.
📌 3 Maddede Bu Makale
Abstract
Current guidelines recommend that patients with cirrhosis be screened for the development of HCC every 6 months. The aim of our study was to determine whether HCC screening is performed with appropriate methods and at appropriate intervals in cirrhotic patients, and to evaluate the outcomes of the screening. This research is a retrospective cohort study. The study included patients aged 18 and over, diagnosed with Child-Pugh class A or B cirrhosis, who applied to our clinic between 2010 and 2020. Patients were divided into two groups: those who underwent guideline-recommended surveillance (imaging with ultrasound, CT, or MRI and/or measurement of AFP every 4-8 months) and those who did not undergo recommended surveillance (insufficient screening or no screening). These groups were compared in terms of HCC development, curative treatment, and survival. A total of 641 cirrhotic patients were included in the study. Only 146 (22.7%) patients underwent guideline-recommended HCC screening. During the follow-up period, a total of 89 patients were diagnosed with HCC (42 patients (28.8%) in the surveillance group and 47 patients (9.5%) in the nonsurveillance group, p<0.001). In the surveillance group, the rate of early-stage HCC detection (83.3% vs. 40.4%), curative treatment rate (78.4% vs. 33.3%), and median survival time (74 vs. 21.7 months) were higher compared to the nonsurveillance group (p<0.001). HCC screening rates in cirrhotic patients are quite low. Guideline-recommended HCC screening in these patients results in earlier diagnosis and increases both the likelihood of receiving curative treatment and overall survival.