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Dergiler / Journal of Experimental and Clinical Medicine / 2025 / Volume: 42 Issue: 4

Effects of capsaicin, a TRPV1 channel agonist, on ketamine-induced psychosis in a mouse model of schizophrenia

Ferruh Karamangil0000-0001-5021-6879
S. Sırrı Bilge(FACULTY OF MEDICINE)0000-0003-2878-6968
Sayfa
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Yayın Tarihi
2025-12-31
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These findings suggest that TRPV1 agonism mitigates ketamine-induced cognitive and motor impairments, highlighting TRPV1 channels as potential therapeutic targets in schizophrenia.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Schizophrenia is a prevalent and challenging psychiatric disorder with limited treatment options due to drug resistance and adverse effects.
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Temel Bulgular & Veri:Emerging evidence suggests a potential role of TRPV1 channels in schizophrenia pathology, associated with disrupted thermoregulation and altered pain responses.
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Sonuç & Katkı:These findings suggest that TRPV1 agonism mitigates ketamine-induced cognitive and motor impairments, highlighting TRPV1 channels as potential therapeutic targets in schizophrenia.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Ketamine · capsaicin · schizophrenia

Abstract

Schizophrenia is a prevalent and challenging psychiatric disorder with limited treatment options due to drug resistance and adverse effects. Emerging evidence suggests a potential role of TRPV1 channels in schizophrenia pathology, associated with disrupted thermoregulation and altered pain responses. This study investigates the effects of capsaicin, a TRPV1 channel agonist, on memory and motor impairments in a ketamine-induced mouse model of schizophrenia. Male C57BL/6 mice received a single intraperitoneal injection of ketamine (10 mg/kg) to induce psychosis-like behaviors. Capsaicin (0.1, 1, and 3 mg/kg, I.P.) was administered 30 minutes before ketamine. Behavioral assessments included the novel object recognition test (NORT) and Y-maze test for memory deficits and the open-field test for locomotor activity. Rearing and grooming were considered stereotypic behaviors. Risperidone (0.5 mg/kg, I.P.) served as the positive control. Capsaicin at 3 mg/kg significantly ameliorated ketamine-induced deficits in object exploration time and spontaneous alternation behaviors, while lower doses were ineffective. Additionally, capsaicin reduced ketamine-induced stereotypical grooming and rearing behaviors. These findings suggest that TRPV1 agonism mitigates ketamine-induced cognitive and motor impairments, highlighting TRPV1 channels as potential therapeutic targets in schizophrenia.

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Bu Makaleye Atıf Yap

Karamangil, F., Bilge, S. S. (2025). Effects of capsaicin, a TRPV1 channel agonist, on ketamine-induced psychosis in a mouse model of schizophrenia. Journal of Experimental and Clinical Medicine, Volume: 42 Issue: 4. https://ajindex.com/articles/1422552

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Kaynakça (23)

  1. Barch DM, Ceaser A. Cognition in schizophrenia: core psychological and neural mechanisms. Trends Cogn Sci. 2012 Jan;16(1):27–34.
  2. Shuba YM. Beyond Neuronal Heat Sensing: Diversity of TRPV1 Heat-Capsaicin Receptor-Channel Functions. Front Cell Neurosci. 2021 Feb 5;14.
  3. Chahl LA. TRP’s: Links to schizophrenia? Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2007 Aug;1772(8):968–77.
  4. Chahl LA. TRPV1 Channels in the Central Nervous System as Drug Targets. Pharmaceuticals. 2024 Jun 7;17(6):756.
  5. Huang J, Huang H, Liu M, Yang W, Wang H. Involvement of the TRPV1 receptor and the endocannabinoid system in schizophrenia. Brain Res Bull. 2024 Sep;215:111007.
  6. Antunes M, Biala G. The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process. 2012 May 9;13(2):93–110.
  7. McDougall SA, Moran AE, Baum TJ, Apodaca MG, Real V. Effects of ketamine on the unconditioned and conditioned locomotor activity of preadolescent and adolescent rats: impact of age, sex, and drug dose. Psychopharmacology (Berl) [Internet]. 2017 Sep 1 [cited 2025 Jan 24];234(18):2683–96. Available from: https://link.springer.com/article/10.1007/s00213-017-4660-3
  8. Chatterjee M, Verma R, Ganguly S, Palit G. Neurochemical and molecular characterization of ketamine-induced experimental psychosis model in mice. Neuropharmacology. 2012 Nov;63(6):1161–71.
  9. Howes O, McCutcheon R, Stone J. Glutamate and dopamine in schizophrenia: An update for the 21st century. Journal of Psychopharmacology. 2015 Feb 13;29(2):97–115.
  10. Lee G, Zhou Y. NMDAR Hypofunction Animal Models of Schizophrenia. Front Mol Neurosci. 2019 Jul 31;12.
  11. Lisek M, Ferenc B, Studzian M, Pulaski L, Guo F, Zylinska L, Boczek T. Glutamate Deregulation in Ketamine-Induced Psychosis—A Potential Role of PSD95, NMDA Receptor and PMCA Interaction. Front Cell Neurosci. 2017 Jun 28;11.
  12. Yang Y, Ju W, Zhang H, Sun L. Effect of Ketamine on LTP and NMDAR EPSC in Hippocampus of the Chronic Social Defeat Stress Mice Model of Depression. Front Behav Neurosci. 2018 Oct 9;12.
  13. Chen PA, Wang HY, Sun CL, Chen ML, Chen YC. Neurobehavioral Differences of Valproate and Risperidone on MK- 801 Inducing Acute Hyperlocomotion in Mice. Behavioural Neurology. 2022 Feb 23; 2022:1–12.
  14. Brisch R, Saniotis A, Wolf R, Bielau H, Bernstein HG, Steiner J, Bogerts B, Braun AK, Jankowski Z, Kumaritlake J, Henneberg M, Gos T. The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue. Front Psychiatry. 2014 May 19;5.
  15. Eun SY, Jun Jung S, Kyung Park Y, Kwak J, Jeong Kim S, Kim J. Effects of Capsaicin on Ca2+ Release from the Intracellular Ca2+ Stores in the Dorsal Root Ganglion Cells of Adult Rats. Biochem Biophys Res Commun. 2001 Aug;285(5):1114–20.
  16. Hudson ASR, Kunstetter AC, Damasceno WC, Wanner SP. Involvement of the TRPV1 channel in the modulation of spontaneous locomotor activity, physical performance and physical exercise-induced physiological responses. Brazilian Journal of Medical and Biological Research. 2016;49(6).
  17. Nazıroglu M, Demirdas A. Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs. Curr Neuropharmacol. 2015 May 25;13(2):248–57.
  18. Chan M, Austen JM, Eacott MJ, Easton A, Sanderson DJ. The NMDA receptor antagonist MK-801 fails to impair long- term recognition memory in mice when the state-dependency of memory is controlled. Neurobiol Learn Mem. 2019 May; 161:57–62.
  19. Guo JY, Ragland JD, Carter CS. Memory and cognition in schizophrenia. Mol Psychiatry. 2019 May 21;24(5):633–42.
  20. Zhang K, Xu T, Yuan Z, Wei Z, Yamaki VN, Huang M, Huganir RL, Cai X. Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-acting antidepressant responses of ketamine. Sci Signal. 2016 Dec 13;9(458).
  21. Kalueff A V., Stewart AM, Song C, Berridge KC, Graybiel AM, Fentress JC. Neurobiology of rodent self-grooming and its value for translational neuroscience. Nat Rev Neurosci. 2016 Jan 17;17(1):45–59.
  22. Davis GL, Minerva AR, Lario A, Simmler LD, Rodriguez CI, Gunaydin LA. Ketamine increases activity of a fronto- striatal projection that regulates compulsive behavior in SAPAP3 knockout mice. Nat Commun. 2021 Oct 15;12(1):6040.
  23. Xu S, Hao K, Xiong Y, Xu R, Huang H, Wang H. Capsaicin alleviates neuronal apoptosis and schizophrenia-like behavioral abnormalities induced by early life stress. Schizophrenia. 2023 Nov 7;9(1).