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Dergiler / Meandros Medical And Dental Journal / 2026 / Volume: 23 Issue: 3

Protective Efficacy of Thiamine (Vitamin B1) Alone on LPS-induced Acute Kidney Injury

Hilal Bektaş Uysal(AYDIN ADNAN MENDERES UNIVERSITY)
Mustafa Yılmaz(ADNAN MENDERES UNIVERSITY)
İmran Kurt Ömurlu(ADNAN MENDERES UNIVERSITY)
Buket Demirci(ADNAN MENDERES UNIVERSITY)
Sayfa
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Yayın Tarihi
2022-09-30
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

With its cheap, readily available, and good safety profile in adults, thiamin appears like a tempting adjunctive therapy for sAKI.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Sepsis-induced acute kidney injury (sAKI) is the leading cause of renal dysfunction and mortality in intensive care unit.
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Temel Bulgular & Veri:We must target its multidimensional pathogenesis for new treatment strategies.
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Sonuç & Katkı:With its cheap, readily available, and good safety profile in adults, thiamin appears like a tempting adjunctive therapy for sAKI.
🔬Tür:Uygulamalı Anket & Alan Araştırması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:sAKI · thiamin · sepsis

Abstract

Objective: Sepsis-induced acute kidney injury (sAKI) is the leading cause of renal dysfunction and mortality in intensive care unit. We must target its multidimensional pathogenesis for new treatment strategies. Therefore, we decided to reveal the protective efficacy of thiamin on sAKI in terms of its antioxidant, anti-inflammatory and mitochondrial regulatory effects. Materials and Methods: Four rat groups were formed as; healthy (HG), sepsis (SG), thiamine (TG), sepsis + thiamine (TSG) groups. In kidney tissue, oxidant [malondialdehyde (MDA), nitric oxide (NO)] and antioxidant (glutathione (GSH), catalase (CAT)] levels were measure. In serum, tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), procalcitonin (PCT) and urea, creatine (Cr), lactate were also surveyed. Results: There were significant decreases in MDA and NO levels (p<0.001, p<0.001, respectively) and increases in GSH and CAT levels (p<0.001, p<0.001, respectively) when TSG and SG groups were compared. Proinflammatory cytokine levels were significantly elevated in SG (p<0.001). In the TSG group, PCT, IL-1β and TNF-α levels were decreased compared with SG (p<0.001 p<0.001, p<0.001, respectively). In the SG group versus HG group results, lactate levels were found to be 4-fold higher (p<0.001) and urea, Cr levels were 3-4 fold higher (p<0.001, p<0.001, respectively). In the TSG group, there was an obvious decrease in lactate and urea, Cr levels compared with SG (p<0.001, p=0.002, p<0.001, respectively). Conclusion: We revealed the preventive efficacy of thiamin against sAKI by reducing the oxidant parameters and proinflammatory cytokine levels and increasing the antioxidant parameter levels with the attainment of near normal kidney functions, simultaneously. With its cheap, readily available, and good safety profile in adults, thiamin appears like a tempting adjunctive therapy for sAKI.

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Bu Makaleye Atıf Yap

Uysal, H. B., Yılmaz, M., Ömurlu, İ. K., Demirci, B. (2022). Protective Efficacy of Thiamine (Vitamin B1) Alone on LPS-induced Acute Kidney Injury. Meandros Medical And Dental Journal, Volume: 23 Issue: 3. https://doi.org/10.4274/meandros.galenos.2022.70456

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Kaynakça (25)

  1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 2016; 315: 801-10.
  2. Bagshaw SM, George C, Dinu I, Bellomo R. A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients. Nephrol Dial Transplant 2007; 23: 1203-10.
  3. Post EH, Kellum JA, Bellomo R, Vincent JL. Renal perfusion in sepsis: From macro- to microcirculation. Kidney Int 2017; 91: 45-60.
  4. Ow CPC, Trask-Marino A, Betrie Ashenafi H, Evans RG, May CN, Lankadeva YR. Targeting Oxidative Stress in Septic Acute Kidney Injury: From Theory to Practice. J Clin Med 2021; 10: 3798.
  5. Moskowitz A, Andersen LW, Huang DT, Berg KM, Grossestreuer AV, Marik PE, et al. Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation. Crit Care 2018; 22: 283.
  6. Singer M. The role of mitochondrial dysfunction in sepsis induced multi-organ failure. Virulence 2014; 5: 66-72.
  7. de Andrade JAA, Gayer CRM, Nogueira NPA, Paes MC, Bastos VLFC, Neto JDCB, et al. The effect of thiamine deficiency on inflammation, oxidative stress and cellular migration in an experimental model of sepsis. J Inflamm (Lond). 2014; 24: 11.
  8. Thurnham DI. Thiamin: physiology. Encyclopedia of Human Nutrition 2013; 274: 279.
  9. Wald EL, Badke CM, Hintz LK, Spewak M, Sanchez-Pinto LN. Vitamin therapy in sepsis. Pediatr Res 2022; 91: 328-36.
  10. Donnino MW, Andersen LW, Chase M, Berg KM, Tidswell M, Giberson T, et al. Center for Resuscitation Science Research Group: Randomized, double-blind, placebo-controlled trial of Thiamine as a metabolic resuscitator in septic shock: A pilot study. Crit Care Med 2016; 44: 360-7.
  11. Belsky JB, Wira CR, Jacob V, Sather JE, Lee PJ. A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. Nutr Res Rev. 2018; 31: 281-90.
  12. Attaluri P, Castillo A, Edriss H, Nugent K. Thiamine Deficiency: An Important Consideration in Critically Ill Patients. Am J Med Sci 2018; 356: 382-90.
  13. Leite HP, de Lima LF. Metabolic resuscitation in sepsis: a necessary step beyond the hemodynamic? J Thorac Dis 2016; 8: E552-7.
  14. Moskowitz A, Donnino MW. Thiamine (vitamin B1) in septic shock: a targeted therapy. J Thorac Dis 2020; 12: S78-S83.
  15. Can C, Demirci B, Uysal A, Akcay YD, Kosay S. Contradictory effects of chlorpromazine on endothelial cells in a rat model of endotoxic shock in association with its actions on serum TNF-alpha levels and antioxidant enzyme activities. Pharmacol Res 2003; 48: 223-30.
  16. Uysal HB, Dağlı B, Yılmaz M, Kahyaoğlu F, Gökçimen A, Ömürlü İK, et al. Biochemical and Histological Effects of Thiamine Pyrophosphate against Acetaminophen-Induced Hepatotoxicity. Basic Clin Pharmacol Toxicol 2016; 118: 70-6.
  17. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-8.
  18. Navarro-Gonzalves JA, Garcia-Benayas C, Arenas J. Semiautomated measurement of nitrate in biological fluids. Clin Chem 1998; 44: 679-81.
  19. Aebi H. Catalase. In: Bergmeyer HU editors. Methods of Enzymatic Analysis. Academic Press: New York, 1974; 673-7.
  20. Beutler E, Durgun O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med 1963; 61: 882-8.
  21. Heemskerk S, Masereeuw R, Russel FGM, Pickkers P. Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury. Nat Rev Nephrol 2009; 5: 629-40.
  22. Shi L, Zhang Y, Xia Y, Li C, Song Z, Zhu J. MiR-150-5p protects against septic acute kidney injury via repressing the MEKK3/JNK pathway. Cell Signal 2021; 86: 110101.
  23. Li L, Liu X, Li S, Wang Q, Wang H, Xu M, et al. Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway. Ren Fail 2021; 43: 1028-40.
  24. Fu G, Zhan HC, Li HL, Lu JF, Chen YH, Wu LF, et al. Association between Procalcitonin and Acute Kidney Injury in Patients with Bacterial Septic Shock. Blood Purif 2021; 50: 790-9.
  25. Counts JP, Rivera VF, Kimmons LA, Jones GM. Thiamine Use in Sepsis: B1 for Everyone? Crit Care Nurs Q 2019; 42: 292-303.