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Journals / Journal of the Turkish Chemical Society Section B: Chemical Engineering / 2023 / Cilt: 6 Sayı: 1

Composite Cryogels for Drug Delivery Applications: A Preliminary Study with Dye as a Model Drug

Didem DEMİR KARAKUŞ
Seda CEYLAN
Nimet BÖLGEN
Pages
17–26
Publication Date
2023-04-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Gels, which swell in a short time, absorb the dye quickly and the cumulative release of the dye indicates that the gels are suitable for extended-release systems.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cryogels are suitable candidates to be used as drug release systems due to their interconnected pore structures, high surface areas, high liquid absorption capacities, and elasticity.
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Key Findings & Data:Successfully crosslinked gels exhibited an interconnected pore structure with an average pore diameter of 52.95 µm.
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Conclusion & Impact:Gels, which swell in a short time, absorb the dye quickly and the cumulative release of the dye indicates that the gels are suitable for extended-release systems.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:chitosan · gelatin · cryogel

Abstract

Cryogels are suitable candidates to be used as drug release systems due to their interconnected pore structures, high surface areas, high liquid absorption capacities, and elasticity. With this purpose, we aimed to produce a cryogel structure to be used in drug release applications with the approach of tissue engineering. As biodegradable and biocompatible polymers chitosan and gelation were selected. The cryogels were fabricated using the combination of these polymers in the presence of glutaraldehyde under cryogenic conditions. The produced optimum gel scaffold was first characterized using FTIR, SEM, porosity, swelling ability, and degradation analyses. Successfully crosslinked gels exhibited an interconnected pore structure with an average pore diameter of 52.95 µm. As a result of the examination of the time-dependent weight change, it was also revealed that the cryogels have a liquid absorption capacity of about 500 times their dry weight and are biodegradable. The mainly characterized cryogel sample was evaluated for potential drug loading and release applications using methyl orange (MO) as a model drug. Gels, which swell in a short time, absorb the dye quickly and the cumulative release of the dye indicates that the gels are suitable for extended-release systems.

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Cite This Article

KARAKUŞ, D. D., CEYLAN, S., BÖLGEN, N. (2023). Composite Cryogels for Drug Delivery Applications: A Preliminary Study with Dye as a Model Drug. Journal of the Turkish Chemical Society Section B: Chemical Engineering, Cilt: 6 Sayı: 1, 17–26. https://ajindex.com/articles/930210

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References (11)

  1. Ak, F., Oztoprak, Z., Karakutuk, I., & Okay, O. (2013). Macroporous Silk Fibroin Cryogels. Biomacromolecules, 14(3), 719–727. https://doi.org/10.1021/bm3018033.
  2. Ayaz, F., Demir, D., & Bölgen, N. (2021). Differential anti-inflammatory properties of chitosan-based cryogel scaffolds depending on chitosan/gelatin ratio. Artificial Cells, Nanomedicine, and Biotechnology, 49(1), 682–690. https://doi.org/10.1080/21691401.2021.2012184.
  3. Bhasarkar, J., & Bal, D. (2019). Kinetic investigation of a controlled drug delivery system based on alginate scaffold with embedded voids. Journal of Applied Biomaterials & Functional Materials, 17(2), 228080001881746. https://doi.org/10.1177/2280800018817462.
  4. Bhat, S., Tripathi, A., & Kumar, A. (2011). Supermacroprous chitosan–agarose–gelatin cryogels: In vitro characterization and in vivo assessment for cartilage tissue engineering. Journal of The Royal Society Interface, 8(57), 540–554. https://doi.org/10.1098/rsif.2010.0455.
  5. Biondi, M., Ungaro, F., Quaglia, F., & Netti, P. A. (2008). Controlled drug delivery in tissue engineering. Advanced Drug Delivery Reviews, 60(2), 229–242. https://doi.org/10.1016/j.addr.2007.08.038.
  6. Demir, D., Ceylan, S., Göktürk, D., & Bölgen, N. (2021). Extraction of pectin from albedo of lemon peels for preparation of tissue engineering scaffolds. Polymer Bulletin, 78(4), 2211–2226. https://doi.org/10.1007/s00289-020-03208-1.
  7. Demir, D., Güreş, D., Tecim, T., Genç, R., & Bölgen, N. (2018). Magnetic nanoparticle-loaded electrospun poly(ε-caprolactone) nanofibers for drug delivery applications. Applied Nanoscience, 8(6), 1461–1469. https://doi.org/10.1007/s13204-018-0830-9.
  8. Demir, D., Öfkeli, F., Ceylan, S., & Bölgen, N. (2016). Extraction and Characterization of Chitin and Chitosan from Blue Crab and Synthesis of Chitosan Cryogel Scaffolds. Journal of the Turkish Chemical Society, Section A: Chemistry, 3(3). https://doi.org/10.18596/jotcsa.00634.
  9. Fernandes Queiroz, M., Melo, K., Sabry, D., Sassaki, G., & Rocha, H. (2014). Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation? Marine Drugs, 13(1), 141–158. https://doi.org/10.3390/md13010141.
  10. Ghanbarzadeh, B., & Almasi, H. (2013). Biodegradable Polymers. In R. Chamy (Ed.), Biodegradation—Life of Science. InTech. https://doi.org/10.5772/56230.
  11. Han, H. D., Song, C. K., Park, Y. S., Noh, K. H., Kim, J. H., Hwang, T., Kim, T. W., & Shin, B. C. (2008). A chitosan hydrogel-based cancer drug delivery system exhibits synergistic antitumor effects by