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Journals / Türk Psikiyatri Dergisi / 2011 / Cilt: 22 - Sayı: 4

Comparing brain magnetic resonance spectroscopy findings of pediatric treatment-naive obsessive-compulsive disorder patients with healthy controls

Tedavi almayan pediatrik obsesif-kompülsif bozukluk hastalarının beyin magnetik rezonans spektroskopi bulgularının sağlıklı kontrollerle karşılaştırılması

ÖZHAN YALÇIN
Şahnur ŞENER
Öznur Leman BOYUNAĞA KONUŞ
Esin Gökçe SARIPINAR
Törel OĞUR
ESRA GÜNEY
BURCU AKIN SARI
ELVAN İŞERİ
Pages
222–229
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Also further studies of the occipital lobes and insula should be continued in OCD.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: It is believed that biochemical alterations in different brain regions are involved in the pathophysiology of obsessive-compulsive disorder (OCD) in children and adolescents.
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Key Findings & Data:Method: Children and adolescents between 8 and 16 years of age with OCD (n:15) and case matched healthy controls (n:15) were recruited for the study.
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Conclusion & Impact:Also further studies of the occipital lobes and insula should be continued in OCD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: It is believed that biochemical alterations in different brain regions are involved in the pathophysiology of obsessive-compulsive disorder (OCD) in children and adolescents. The aim of this study was to explore possible metabolic variations between pediatric OCD cases and healthy controls in brain regions which were implicated in OCD pathophysiology. Method: Children and adolescents between 8 and 16 years of age with OCD (n:15) and case matched healthy controls (n:15) were recruited for the study. After detailed clinical and neuropsychological evaluations, all subjects underwent the multiregional magnetic resonance spectroscopy (MRS) procedure with a long echo time (TE:135). Results: Significantly lower n-acetylaspartate (NAA) ratios in the left inferior frontal gyrus, right occipital grey matter, left anterior cingulate cortex and lower choline (Cho) ratios in right and left anterior cingulate cortex and higher Cho ratio in left lenticular nucleus was observed in the OCD group. Also we found a negative correlation between OCD duration and left insular cortex NAA/Cho ratio. Conclusion: We found significant metabolic alterations in the brain regions which were implicated in OCD pathophysiology. Lower NAA and Cho ratios in anterior cingulate cortex and lower NAA ratios in the left inferior fronyal gyrus containing lateral orbitofrontal cortex can be possibly related to higher activation in OCD patients. Also further studies of the occipital lobes and insula should be continued in OCD.

Özet

Amaç: Çocuk ve ergenlerdeki Obsesif-Kompülsif Bozukluk (OKB) patofizyolojisinde değişik beyin bölgelerindeki metabolik farklılıkların önemli olabileceğine vurgu yapılmaktadır. Bu çalışma ile amacımız, tedavi almayan pediatrik OKB tanısı alan olgularla, sağlıklı kontrollerin OKB patofizyolojisinde önemli olabilecek alanlarda olası metabolik farklılıklarının araştırılmasıdır. Yöntem: Yaşları 8 ile 16 arasında değişen OKB tanısı alan çocuk ve ergenler (n:15) ve cinsiyet, yaş, el tercihi bakımından eşleştirilmiş kontrol grubu (n:15) çalışmaya alındı. Detaylı klinik ve nörospikolojik incelemeden sonra katılımcılar uzun echo zamanın (TE:135) kullanıldığı beyin magnetik rezonans spektroskopi işlemine tabii tutuldu. Bulgular: OKB grubunda istatistiksel olarak anlamlı derecede daha düşük sol inferior frontal girus, sağ oksipital gri cevher, sol ön singulat korteks n-asetilaspartat (NAA); daha düşük sağ ve sol ön singulat korteks kolin (Cho); daha yüksek sol lentiküler çekirdek Cho oranları saptandı. Ayrıca OKB grubunda OKB hastalık süresi ile sol insular korteks NAA/Cho oranları arasında negatif korelasyon tespit edildi. Sonuç: OKB patofizyolojisinde önemli olabileceği gösterilmiş alanlarda önemli metabolik farklılıklar saptadık. OKB’de ön singulat korteksteki azalmış NAA ve Cho oranları ve sol lateral orbitofrontal korteksi de içine alan sol inferior frontal girus’taki azalmış NAA oranları, bu bölgedeki muhtemel aktivasyon artışı ile ilişkili olabilir. Ayrıca OKB’de insula ve oksipital loblar daha fazla çalışılmayı hak etmektedir.

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Cite This Article

YALÇIN, Ö., ŞENER, Ş., KONUŞ, Ö. L. B., SARIPINAR, E. G., OĞUR, T., GÜNEY, E., SARI, B. A., İŞERİ, E. (2011). Comparing brain magnetic resonance spectroscopy findings of pediatric treatment-naive obsessive-compulsive disorder patients with healthy controls. Türk Psikiyatri Dergisi, Cilt: 22 - Sayı: 4, 222–229. https://ajindex.com/articles/89107

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