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Journals / Türk Psikiyatri Dergisi / 2018 / Cilt: 29 - Sayı: 4

The Association between the Extended Psychosis Phenotype and COMT val158met and BDNF val66met polymorphisms

Geniş Psikoz Fenotipinin COMT val158met ve BDNF val66met Polimorfizmleri ile İlişkisi

İBRAHİM TOLGA BİNBAY
UMUT KIRLI
Emre MISIR
HAYRİYE ELBİ
BÜLENT KAYAHAN
HÜSEYİN ONAY
Ferda ÖZKINAY
Marjan DRUKKER
jim van OS
KÖKSAL ALPTEKİN
Pages
221–228
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The lack of an association between different expression levels of the extended psychosis phenotype and the BDNF rs6265/ COMT rs4680 polymorphism might be related to sample characteristics, underlying gene-gene, gene-environment and gene-environment-gene interactions.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Psychotic disorders were previously associated with catechol- O-methyltransferase (COMT) val158met (rs4680) and brain-derived neurotrophic factor (BDNF) val66met (rs6265) polymorphisms.
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Key Findings & Data:Method: The participants of this study were part of the TürkSch (Izmir Mental Health Survey for Gene-Environment Interaction in Psychoses), a longitudinal study Psychotic experiences and disorders were screened 437.
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Conclusion & Impact:Conclusion: The lack of an association between different expression levels of the extended psychosis phenotype and the BDNF rs6265/ COMT rs4680 polymorphism might be related to sample characteristics, underlying gene-gene, gene-environment and gene-environment-gene interactions.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Psychotic disorders were previously associated with catechol- O-methyltransferase (COMT) val158met (rs4680) and brain-derived neurotrophic factor (BDNF) val66met (rs6265) polymorphisms. This article evaluates the association between COMT/BDNF polymorphisms and the extended psychosis phenotype which covers not only schizophrenia but also subclinical expressions of psychotic experiences. Method: The participants of this study were part of the TürkSch (Izmir Mental Health Survey for Gene-Environment Interaction in Psychoses), a longitudinal study Psychotic experiences and disorders were screened 437. The extended psychosis phenotype was grouped into four: (1) no psychotic experiences (n: 194), (2) subclinical psychotic experiences (n: 87), (3) clinically relevant psychotic experiences (n: 104), and (4) schizophrenia-like disorders (n: 52). BDNF rs6265 was genotyped occurred in every participant whereas COMT rs4680 genotyping could be done on 366 individuals. Results: There was no association between the extended psychosis phenotype and BDNF rs6265/COMT rs4680 polymorphisms. The frequency of met carriers in the BDNF rs6265genotype was slightly higher in individuals with subclinical psychotic experiences than in the group with no psychotic experiences, which was just below the significance level (p=0.08). Conclusion: The lack of an association between different expression levels of the extended psychosis phenotype and the BDNF rs6265/ COMT rs4680 polymorphism might be related to sample characteristics, underlying gene-gene, gene-environment and gene-environment-gene interactions.

Özet

Amaç: Psikotik bozukluklar ile Katekol-O-metiltransferaz (COMT) val158met (rs4680) ve beyin kökenli nörotrofik faktör (Brain-derived neurotrophic factor; BDNF) val66met (rs6265) polimorfizmleri arasında ilişki olabileceği düşünülmektedir. Bu araştırmada genel toplumdan seçilmiş bir örneklemde eşik altı psikotik yaşantılardan şizofreniye geniş psikoz fenotipi boyunca bu polimorfizmlerin dağılımının incelenmesi amaçlanmıştır. Yöntem: Örneklem, uzunlamasına bir izlem araştırması olan Psikozlarda Gen-Çevre Etkileşimi İçin İzmir Akıl Sağlığı Araştırması’na (TürkSch) dayanmaktadır ve psikotik yaşantı ve bozuklukların tarandığı bir genel toplum örneklemi içinden seçilen 437 kişiden oluşmaktadır. Geniş psikoz fenotipi, tarama ve klinik tanı görüşmelerine göre psikotik yaşantısı olmayanlar (n: 194), eşik altı psikotik yaşantısı olanlar (n: 87), psikotik yaşantısı olanlar (n: 104) ve şizofreni-benzeri bozukluk (n: 52) grupları olarak oluşturulmuştur. BDNF rs6265 genotiplendirmesi araştırmaya katılan tüm kişilerde ve COMT rs4680 genotiplendirmesi ise 366 kişide yapılmıştır. Bulgular: Geniş psikoz fenotipi grupları arasında BDNF rs6265 ve COMT rs4680 polimorfizmleri açısından anlamlı farklılık bulunmamıştır. Sadece herhangi bir psikotik yaşantı bildirmeyenlere göre eşik altı psikotik yaşantı bildirenlerde BDNF rs6265 genotipinde met taşıyanların bulunma olasılığı anlamlılığa yakın düzeyde daha düşük bulunmuştur (p=0,08). Sonuç: Geniş psikoz fenotipinin farklı basamakları ile BDNF rs6265 ve COMT rs4680 arasında bir ilişki bulunmaması altta yatan gen-gen etkileşimi, gen-çevre ve gen-gen-çevre etkileşimi gibi daha karmaşık mekanizmaların varlığıyla ilişkili olabilir.

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Cite This Article

BİNBAY, İ. T., KIRLI, U., MISIR, E., ELBİ, H., KAYAHAN, B., ONAY, H., ÖZKINAY, F., DRUKKER, M., OS, J. V., ALPTEKİN, K. (2018). The Association between the Extended Psychosis Phenotype and COMT val158met and BDNF val66met polymorphisms. Türk Psikiyatri Dergisi, Cilt: 29 - Sayı: 4, 221–228. https://ajindex.com/articles/87849

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