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Journals / International Journal of Chemistry and Technology / 2022 / Cilt: 6 - Sayı: 1

Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

Benzoik asit halkali yeni hibrit kalkonlarin sentezi ve biyolojik aktiviteleri

Bedriye Seda KURŞUN AKTAR
Yusuf SICAK
Emine Elçin ORUÇ-EMRE
Pages
7–14
Publication Date
2022-07-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1.

📌 3 Key Takeaways

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Objective & Hypothesis:A series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid.
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Key Findings & Data:The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined.
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Conclusion & Impact:It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Chalcone · Anticholinesterase activity · Tyrosinase inhibitory activity

Abstract

A series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid. The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined. It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1. Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.

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Cite This Article

AKTAR, B. S. K., SICAK, Y., ORUÇ-EMRE, E. E. (2022). Synthesis and biological activities of new hybrid chalcones with benzoic acid ring. International Journal of Chemistry and Technology, Cilt: 6 - Sayı: 1, 7–14. https://ajindex.com/articles/764927

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