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Dergiler / International Journal of Chemistry and Technology / 2022 / Cilt: 6 - Sayı: 1

Benzoik asit halkali yeni hibrit kalkonlarin sentezi ve biyolojik aktiviteleri

Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

Bedriye Seda KURŞUN AKTAR
Yusuf SICAK
Emine Elçin ORUÇ-EMRE
Sayfa
7–14
Yayın Tarihi
2022-07-06
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.

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Amaç & Hipotez:A series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid.
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Temel Bulgular & Veri:The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined.
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Sonuç & Katkı:Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Chalcone · Anticholinesterase activity · Tyrosinase inhibitory activity

Abstract

A series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid. The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined. It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1. Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.

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Bu Makaleye Atıf Yap

AKTAR, B. S. K., SICAK, Y., ORUÇ-EMRE, E. E. (2022). Benzoik asit halkali yeni hibrit kalkonlarin sentezi ve biyolojik aktiviteleri. International Journal of Chemistry and Technology, Cilt: 6 - Sayı: 1, 7–14. https://ajindex.com/articles/764927

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