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Dergiler / International Journal of Chemistry and Technology / 2026 / Issue: 11

Biomonitoring of Organochlorine Pesticides and Polychlorinated Biphenyls in Paired Placental Tissue and Umbilical Cord Blood in IUGR and Control Pregnancies

Harun Şener(KÜTAHYA SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, MÜHENDİSLİK VE DOĞA BİLİMLERİ FAKÜLTESİ, ADLİ BİLİMLER BÖLÜMÜ, ADLİ BİLİMLER ANABİLİM DALI)0000-0003-3521-0684
İsmail Bıyık(KÜTAHYA SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ)0000-0001-6111-9302
Eda Nur Ay(KÜTAHYA SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, MÜHENDİSLİK VE DOĞA BİLİMLERİ FAKÜLTESİ, ADLİ BİLİMLER BÖLÜMÜ, ADLİ BİLİMLER ANABİLİM DALI)0000-0001-9070-253X
Sayfa
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Yayın Tarihi
2026-09-18
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Because of the small sample size and low detection frequencies, the study should be interpreted as an exploratory, hypothesis-generating pilot study rather than as a definitive assessment of the association between POP exposure and IUGR.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Persistent organic pollutants, such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), can persist in the human body and reach the fetus via transplacental transfer.
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Temel Bulgular & Veri:In this exploratory pilot case-control biomonitoring study, we measured selected OCPs and PCBs in paired placental tissue and umbilical cord blood obtained at delivery from 22 singleton pregnancies in Kütahya, Türkiye, which included 12 intrauterine growth restriction (IUGR) cases and 10 controls.
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Sonuç & Katkı:Because of the small sample size and low detection frequencies, the study should be interpreted as an exploratory, hypothesis-generating pilot study rather than as a definitive assessment of the association between POP exposure and IUGR.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Intrauterine growth restriction (IUGR) · organochlorine pesticides (OCPs) · polychlorinated biphenyls (PCBs)

Abstract

Persistent organic pollutants, such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), can persist in the human body and reach the fetus via transplacental transfer. In this exploratory pilot case-control biomonitoring study, we measured selected OCPs and PCBs in paired placental tissue and umbilical cord blood obtained at delivery from 22 singleton pregnancies in Kütahya, Türkiye, which included 12 intrauterine growth restriction (IUGR) cases and 10 controls. Fifteen target analytes were quantified by GC-ECD following solid-phase extraction using Oasis HLB cartridges. Most measurements fell below the limit of quantification (LOQ), so detectability (≥LOQ vs. <LOQ) was used as the main endpoint. At least one analyte was quantified in 7 of 22 placental samples and in 7 of 22 cord blood samples. Placental quantifications included γ-HCH, o,p′-DDT, PCB-101, PCB-118 and o,p′-DDD, while cord blood quantifications were limited to p,p′-DDD, PCB-118 and o,p′-DDE. No significant differences in analyte detectability were observed between IUGR and control pregnancies. Due to the low detection rate, this study had limited statistical power to establish a definitive association between POP exposure and IUGR. These results indicate that paired placental tissue–cord blood biomonitoring is a feasible approach for interpreting low-level OCP and PCB exposure in Türkiye. Because of the small sample size and low detection frequencies, the study should be interpreted as an exploratory, hypothesis-generating pilot study rather than as a definitive assessment of the association between POP exposure and IUGR.

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Bu Makaleye Atıf Yap

Şener, H., Bıyık, İ., Ay, E. N. (2026). Biomonitoring of Organochlorine Pesticides and Polychlorinated Biphenyls in Paired Placental Tissue and Umbilical Cord Blood in IUGR and Control Pregnancies. International Journal of Chemistry and Technology, Issue: 11. https://doi.org/10.32571/ijct.1940940

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Kaynakça (27)

  1. Al-Saleh, I., Al-Doush, I., Alsabbaheen, A., Mohamed, G. E. D., & Rabbah, A. (2012). Levels of DDT and its metabolites in placenta, maternal and cord blood and their potential influence on neonatal anthropometric measures. Science of the Total Environment, 416, 62–74. https://doi.org/10.1016/j.scitotenv.2011.11.020
  2. Anand, M., & Taneja, A. (2020). Organochlorine pesticides residue in placenta and their influence on anthropometric measures of infants. Environmental Research, 182, Article 109106. https://doi.org/10.1016/j.envres.2019.109106
  3. Anscombe, F. J. (1956). On estimating binomial response relations. Biometrika, 43(3–4), 461–464. https://doi.org/10.1093/biomet/43.3-4.461
  4. Björvang, R. D., Vinnars, M.-T., Papadogiannakis, N., Gidlöf, S., Mamsen, L. S., Mucs, D., Kiviranta, H., Rantakokko, P., Ruokojärvi, P., Lindh, C. H., Andersen, C. Y., & Damdimopoulou, P. (2021). Mixtures of persistent organic pollutants are found in vital organs of late gestation human fetuses. Chemosphere, 283, Article 131125. https://doi.org/10.1016/j.chemosphere.2021.131125
  5. Burton, G. J., & Jauniaux, E. (2018). Pathophysiology of placental-derived fetal growth restriction. American Journal of Obstetrics and Gynecology, 218(2S), S745–S761. https://doi.org/10.1016/j.ajog.2017.11.577
  6. Cabrera-Rodríguez, R., Luzardo, O. P., Almeida-González, M., Boada, L. D., Zumbado, M., Acosta-Dacal, A., Rial-Berriel, C., & Henríquez-Hernández, L. A. (2019). Association between prenatal exposure to multiple persistent organic pollutants (POPs) and growth indicators in newborns. Environmental Research, 171, 285–292. https://doi.org/10.1016/j.envres.2018.12.064
  7. Choi, S., Kim, H.-J., Kim, S., Choi, G., Kim, S., Park, J., Shim, S.-S., Lee, I., Kim, S., Moon, H.-B., Choi, K., Lee, J. J., & Kim, S. Y. (2018). Current status of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) exposure among mothers and their babies of Korea-CHECK cohort study. Science of the Total Environment, 618, 674–681. https://doi.org/10.1016/j.scitotenv.2017.07.232
  8. Dudink, I., Hüppi, P. S., Sizonenko, S. V., Castillo-Melendez, M., Sutherland, A. E., Allison, B. J., & Miller, S. L. (2022). Altered trajectory of neurodevelopment associated with fetal growth restriction. Experimental Neurology, 347, Article 113885. https://doi.org/10.1016/j.expneurol.2021.113885
  9. Gómara, B., Athanasiadou, M., Quintanilla-López, J. E., González, M. J., & Bergman, Å. (2012). Polychlorinated biphenyls and their hydroxylated metabolites in placenta from Madrid mothers. Environmental Science and Pollution Research, 19(1), 139–147. https://doi.org/10.1007/s11356-011-0545-x
  10. Gordijn, S. J., Beune, I. M., Thilaganathan, B., Papageorghiou, A., Baschat, A. A., Baker, P. N., Silver, R. M., Wynia, K., & Ganzevoort, W. (2016). Consensus definition of fetal growth restriction: A Delphi procedure. Ultrasound in Obstetrics & Gynecology, 48(3), 333–339. https://doi.org/10.1002/uog.15884
  11. Govarts, E., Nieuwenhuijsen, M., Schoeters, G., Ballester, F., Bloemen, K., de Boer, M., Chevrier, C., Eggesbø, M., Guxens, M., Krämer, U., Legler, J., Martínez, D., Palkovicova, L., Patelarou, E., Ranft, U., Rautio, A., Petersen, M. S., Slama, R., Stigum, H., … Bonde, J. P. (2012). Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE): A meta-analysis within 12 European birth cohorts. Environmental Health Perspectives, 120(2), 162–170. https://doi.org/10.1289/ehp.1103767
  12. Haldane, J. B. S. (1956). The estimation and significance of the logarithm of a ratio of frequencies. Annals of Human Genetics, 20(4), 309–311. https://doi.org/10.1111/j.1469-1809.1955.tb01285.x
  13. Helou, K., Matta, J., Harmouche-Karaki, M., Sayegh, N., Younes, H., Mahfouz, Y., Mahfouz, M., Karake, S., Finan, R., Abi-Tayeh, G., & Narbonne, J.-F. (2021). Maternal and cord serum levels of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) among Lebanese pregnant women and predictors of exposure. Chemosphere, 266, Article 129211. https://doi.org/10.1016/j.chemosphere.2020.129211
  14. Iribarne-Durán, L. M., Castillero-Rosales, I., Peinado, F. M., Artacho-Cordón, F., Molina-Molina, J. M., Medianero, E., Nicolás-Delgado, S. I., Sánchez-Pinzón, L., Núñez-Samudio, V., Vela-Soria, F., Olea, N., & Alvarado-González, N. E. (2024). Placental concentrations of xenoestrogenic organochlorine pesticides and polychlorinated biphenyls and assessment of their xenoestrogenicity in the PA-MAMI mother-child cohort. Environmental Research, 241, Article 117622. https://doi.org/10.1016/j.envres.2023.117622
  15. Jeong, Y., Lee, S., Kim, S., Park, J., Kim, H.-J., Choi, G., Choi, S., Kim, S., Kim, S. Y., Kim, S., Choi, K., & Moon, H.-B. (2018). Placental transfer of persistent organic pollutants and feasibility using the placenta as a non-invasive biomonitoring matrix. Science of the Total Environment, 612, 1498–1505. https://doi.org/10.1016/j.scitotenv.2017.07.054
  16. Liu, B., Lu, X., Jiang, A., Lv, Y., Zhang, H., & Xu, B. (2024). Influence of maternal endocrine disrupting chemicals exposure on adverse pregnancy outcomes: A systematic review and meta-analysis. Ecotoxicology and Environmental Safety, 270, Article 115851. https://doi.org/10.1016/j.ecoenv.2023.115851
  17. López-Espinosa, M.-J., Granada, A., Carreño, J., Salvatierra, M., Olea-Serrano, F., & Olea, N. (2007). Organochlorine pesticides in placentas from Southern Spain and some related factors. Placenta, 28(7), 631–638. https://doi.org/10.1016/j.placenta.2006.09.009
  18. Nardozza, L. M. M., Caetano, A. C. R., Zamarian, A. C. P., Mazzola, J. B., Silva, C. P., Marçal, V. M. G., Lobo, T. F., Peixoto, A. B., & Araujo Júnior, E. (2017). Fetal growth restriction: Current knowledge. Archives of Gynecology and Obstetrics, 295(5), 1061–1077. https://doi.org/10.1007/s00404-017-4341-9
  19. Ogunbolude, O. K., Oyekanmi, O. F., Olatunji, F. T., Idowu, C. F., Aremu, A. E., & Olawale, M. O. (2025). Synthesis of carbon-nanomaterial from rice husk and its application as adsorbent in pesticide residues analysis. International Journal of Chemistry and Technology, 9(1), 56–68. https://doi.org/10.32571/ijct.1589832
  20. Omoding, D., Nantume, T., Wasswa, J., Odongo, S., Kyarimpa, C., Karume, I., Matovu, H., Sillanpää, M., Kato, C. D., Nabuuma, J., Miiro, A., & Ssebugere, P. (2026). Organochlorine pesticides in placenta, blood and breast milk of mothers in Uganda: Concentrations and health risks to breast fed infants. Journal of Hazardous Materials Advances, 21, Article 100949. https://doi.org/10.1016/j.hazadv.2025.100949
  21. Ozen, T., Telci, I., Gul, F., & Demirtas, I. (2017). Chemical analyzes and antioxidant activities of essential oils of four wild Mentha species growing in the Tokat and its districts. International Journal of Chemistry and Technology, 1(1), 46–57. https://doi.org/10.32571/ijct.343582
  22. Qi, S.-Y., Xu, X.-L., Ma, W.-Z., Deng, S.-L., Lian, Z.-X., & Yu, K. (2022). Effects of organochlorine pesticide residues in maternal body on infants. Frontiers in Endocrinology, 13, Article 890307. https://doi.org/10.3389/fendo.2022.890307
  23. Shanle, E. K., & Xu, W. (2011). Endocrine disrupting chemicals targeting estrogen receptor signaling: Identification and mechanisms of action. Chemical Research in Toxicology, 24(1), 6–19. https://doi.org/10.1021/tx100231n
  24. Toichuev, R. M., Zhilova, L. V., Paizildaev, T. R., Khametova, M. S., Rakhmatillaev, A., Sakibaev, K. S., Madykova, Z. A., Toichueva, A. U., Schlumpf, M., Weber, R., & Lichtensteiger, W. (2018). Organochlorine pesticides in placenta in Kyrgyzstan and the effect on pregnancy, childbirth, and newborn health. Environmental Science and Pollution Research, 25(32), 31885–31894. https://doi.org/10.1007/s11356-017-0962-6
  25. Vizcaíno, E., Grimalt, J. O., Fernández-Somoano, A., & Tardón, A. (2014). Transport of persistent organic pollutants across the human placenta. Environment International, 65, 107–115. https://doi.org/10.1016/j.envint.2014.01.004
  26. Yalçın, S. S., Güneş, B., Arıkan, K., Balçık, O., Kara, Ö., & Yalçın, S. (2024). Exploring the levels of persistent organic pollutants in umbilical cord blood and their connection to gestational age and birth weights in Şanlıurfa, Turkey. BMC Pregnancy and Childbirth, 24(1), Article 501. https://doi.org/10.1186/s12884-024-06677-8
  27. Zhang, X., Wu, X., Lei, B., Jing, Y., Jiang, Z., Zhang, X., Fang, X., & Yu, Y. (2018). Transplacental transfer characteristics of organochlorine pesticides in paired maternal and cord sera, and placentas and possible influencing factors. Environmental Pollution, 233, 446–454.https://doi.org/10.1016/j.envpol.2017.10.075