SavedAdd your journal

Journals / Gaziosmanpaşa Bilimsel Araştırma Dergisi / 2021 / Cilt: 10 - Sayı: 3

Phytochemical screening and radical scavenging activity of green coffee bean extract: Multiple-protective efficacy against Bisphenol A

Burhan DURHAN
Emine YALÇIN
Kültigin ÇAVUŞOĞLU
Ali ACAR
Pages
256–275
Publication Date
2021-12-31
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Bisphenol A, Comet, Green coffee bean extract, Phytochemical characterization, Radical scavenging activity

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, phytochemical characterization, radical scavenging activity and the protective role of green coffee bean extract (Gcbe) against Bisphenol-A (BpA) were evaluated.
📊
Key Findings & Data:For this purpose, mice were separated into six groups which treated with tap-water, BpA and two doses of Gcbe.
💡
Conclusion & Impact:Bisphenol A, Comet, Green coffee bean extract, Phytochemical characterization, Radical scavenging activity
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Bisphenol A · Comet · Green coffee bean extract

Abstract

In this study, phytochemical characterization, radical scavenging activity and the protective role of green coffee bean extract (Gcbe) against Bisphenol-A (BpA) were evaluated. In phytochemical analysis total phenolic, flavonoid and tannin contents were investigated and major components were determined by HPLC. The amerolative effect of Gcbe against BpA-induced toxicity were studied in albino mice. For this purpose, mice were separated into six groups which treated with tap-water, BpA and two doses of Gcbe. To determine BpA toxicity and the protective role of Gcbe, changes in some biochemical parameters, micronucleus (MN) frequency and DNA fragmentation were investigated. As a result, the phenolic compounds in the Gcbe content were more intense than the other components. In BpA-treated group, serum parameters increased and the antioxidant/oxidant dynamics were impaired. Gcbe treatment decreased the induced serum parameters and caused an improvement in antioxidant-oxidant dynamics and also a decrease in the DNA-tail percentage and MN frequency. Bisphenol A, Comet, Green coffee bean extract, Phytochemical characterization, Radical scavenging activity

Özet

In this study, phytochemical characterization, radical scavenging activity and the protective role of green coffee bean extract (Gcbe) against Bisphenol-A (BpA) were evaluated. In phytochemical analysis total phenolic, flavonoid and tannin contents were investigated and major components were determined by HPLC. The amerolative effect of Gcbe against BpA-induced toxicity were studied in albino mice. For this purpose, mice were separated into six groups which treated with tap-water, BpA and two doses of Gcbe. To determine BpA toxicity and the protective role of Gcbe, changes in some biochemical parameters, micronucleus (MN) frequency and DNA fragmentation were investigated. As a result, the phenolic compounds in the Gcbe content were more intense than the other components. In BpA-treated group, serum parameters increased and the antioxidant/oxidant dynamics were impaired. Gcbe treatment decreased the induced serum parameters and caused an improvement in antioxidant-oxidant dynamics and also a decrease in the DNA-tail percentage and MN frequency.

🔖

Cite This Article

DURHAN, B., YALÇIN, E., ÇAVUŞOĞLU, K., ACAR, A. (2021). Phytochemical screening and radical scavenging activity of green coffee bean extract: Multiple-protective efficacy against Bisphenol A. Gaziosmanpaşa Bilimsel Araştırma Dergisi, Cilt: 10 - Sayı: 3, 256–275. https://ajindex.com/articles/761026

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Allard, P., Colaiacovo, M. P., 2010. Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities. Proceedings of the National Academy of Sciences of the United States of America, 107(47), 20405-20410.
  2. Alristina, A. D., Adi, A. C., Ismawati, R., 2018. The effect of green coffee bean extract on the weight rats with high fat diet. Health Notions, 2(4), 446-449.
  3. Anet, A., Olakkaran, S., Purayil, A. K., Puttaswamygowda, G. H., 2019. Bisphenol A induced oxidative stress mediated genotoxicity in Drosophila melanogaster. The Journal of Hazardous Materials, 370, 42-53.
  4. Bhattacharya, S., Sil, P. C., 2018. Role of plant-derived polyphenols in reducing oxidative stress-mediated diabetic complications. Reactive oxygen species, 5(13), 15-34.
  5. Bindhumol, V., Chitra, K. C., Mathur P. P., 2003. Bisphenol A inducers reactive oxygen species generation in the liver of male rats. Toxicology, 188(2-3), 117-124.
  6. Del Castillo, M. D., Ames, J. M., Gordon, M. H., 2002. Effect of roasting on the antioxidant activity of coffee brews. Journal of Agricultural and Food Chemistry, 50(13), 3698-3703.
  7. Dewanto, V., Wu, X., Liu, R. H., 2002. Processed sweet corn has higher antioxidant activity. Journal of Agricultural and Food Chemistry, 50(17), 4959-4964.
  8. Ebert, E. C., Nagart, M., 2008. Gastrointestinal manifestations of amyloidosis. The American Journal of Gastroenterology, 103(3), 776-787.
  9. Edres, H. A., Taha, N. M., Mandour, A. E. W. A., Lebda, M. A., 2018. Impact of L-carnitine on bisphenol A-induced kidney damage in rats. Alexandria Journal of Veterinary Sciences, 56(1), 11-17.
  10. Eshak, M. G., Osman, H. F., 2014. Biological effects of chitosan against bisphenol-A induced endocrine toxicity and androgen receptor gene expression changes in male rats. International Journal of Pharmaceutical and Clinical Research, 6(4), 300-311.
  11. Fisher, J. W., Twaddle, N. C., Vanlandingham, M., Doerge, D. R., 2011. Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. Toxicology and Applied Pharmacology, 257(1), 122-136.
  12. Godos, J., Pluchinotta, F. R., Marventano, S., Buscemi, S., Volti, G. L., Galvano, F., Grosso, G., 2014. Coffee components and cardiovascular risk: beneficial and detrimental effects. International Journal of Food Sciences and Nutrition, 65(8), 925-936.
  13. Gülçin, İ., 2010. Antioxidant properties of resveratrol: a structure–activity insight. Innovative Food Scien