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Dergiler / Gaziosmanpaşa Bilimsel Araştırma Dergisi / 2021 / Cilt: 10 - Sayı: 3

Phytochemical screening and radical scavenging activity of green coffee bean extract: Multiple-protective efficacy against Bisphenol A

Burhan DURHAN
Emine YALÇIN
Kültigin ÇAVUŞOĞLU
Ali ACAR
Sayfa
256–275
Yayın Tarihi
2021-12-31
DOI
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Gcbe treatment decreased the induced serum parameters and caused an improvement in antioxidant-oxidant dynamics and also a decrease in the DNA-tail percentage and MN frequency.

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Amaç & Hipotez:In this study, phytochemical characterization, radical scavenging activity and the protective role of green coffee bean extract (Gcbe) against Bisphenol-A (BpA) were evaluated.
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Temel Bulgular & Veri:For this purpose, mice were separated into six groups which treated with tap-water, BpA and two doses of Gcbe.
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Sonuç & Katkı:Gcbe treatment decreased the induced serum parameters and caused an improvement in antioxidant-oxidant dynamics and also a decrease in the DNA-tail percentage and MN frequency.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Bisphenol A · Comet · Green coffee bean extract

Özet

In this study, phytochemical characterization, radical scavenging activity and the protective role of green coffee bean extract (Gcbe) against Bisphenol-A (BpA) were evaluated. In phytochemical analysis total phenolic, flavonoid and tannin contents were investigated and major components were determined by HPLC. The amerolative effect of Gcbe against BpA-induced toxicity were studied in albino mice. For this purpose, mice were separated into six groups which treated with tap-water, BpA and two doses of Gcbe. To determine BpA toxicity and the protective role of Gcbe, changes in some biochemical parameters, micronucleus (MN) frequency and DNA fragmentation were investigated. As a result, the phenolic compounds in the Gcbe content were more intense than the other components. In BpA-treated group, serum parameters increased and the antioxidant/oxidant dynamics were impaired. Gcbe treatment decreased the induced serum parameters and caused an improvement in antioxidant-oxidant dynamics and also a decrease in the DNA-tail percentage and MN frequency.

Abstract

In this study, phytochemical characterization, radical scavenging activity and the protective role of green coffee bean extract (Gcbe) against Bisphenol-A (BpA) were evaluated. In phytochemical analysis total phenolic, flavonoid and tannin contents were investigated and major components were determined by HPLC. The amerolative effect of Gcbe against BpA-induced toxicity were studied in albino mice. For this purpose, mice were separated into six groups which treated with tap-water, BpA and two doses of Gcbe. To determine BpA toxicity and the protective role of Gcbe, changes in some biochemical parameters, micronucleus (MN) frequency and DNA fragmentation were investigated. As a result, the phenolic compounds in the Gcbe content were more intense than the other components. In BpA-treated group, serum parameters increased and the antioxidant/oxidant dynamics were impaired. Gcbe treatment decreased the induced serum parameters and caused an improvement in antioxidant-oxidant dynamics and also a decrease in the DNA-tail percentage and MN frequency. Bisphenol A, Comet, Green coffee bean extract, Phytochemical characterization, Radical scavenging activity

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Bu Makaleye Atıf Yap

DURHAN, B., YALÇIN, E., ÇAVUŞOĞLU, K., ACAR, A. (2021). Phytochemical screening and radical scavenging activity of green coffee bean extract: Multiple-protective efficacy against Bisphenol A. Gaziosmanpaşa Bilimsel Araştırma Dergisi, Cilt: 10 - Sayı: 3, 256–275. https://ajindex.com/articles/761026

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Kaynakça (13)

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