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Journals / Ulusal Romatoloji Dergisi / 2022 / Cilt: 14 - Sayı: 2

Serum amyloid A may be a potential biomarker for vasculitis

Serum amiloid A vaskülit değerlendirmede potansiyel bir biyobelirteç olabilir

Hakan BABAOĞLU
Pages
100–105
Publication Date
2022-11-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

SAA had the most significant correlation with BVAS (r=0.63, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: There are still unmet needs for ideal biomarkers for management of vasculitis.
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Key Findings & Data:This study aimed to analyze the potential utilities of the S100A12 and Serum Amyloid A (SAA) as diagnostic or activity-specific biomarkers of vasculitis.
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Conclusion & Impact:SAA had the most significant correlation with BVAS (r=0.63, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: There are still unmet needs for ideal biomarkers for management of vasculitis. This study aimed to analyze the potential utilities of the S100A12 and Serum Amyloid A (SAA) as diagnostic or activity-specific biomarkers of vasculitis. Methods: A total of 18 clinically active vasculitis patients [giant cell arteritis (n=6), Takayasu arteritis (n=6), and granulomatosis with polyangiitis (n=6)] and 12 healthy controls (HCs) were enrolled. Disease activity was assessed using the Birmingham disease activity score (BVAS). The correlation between SAA, S100A12, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and BVAS was analyzed. Receiver operating characteristics analysis was used to evaluate the diagnostic utility of each marker. Results: Patients with active vasculitis had significantly higher levels of CRP, S100A12, and SAA, and higher ratios of NLR and PLR compared to HCs. S100A12 did not correlate with disease activity and other biomarkers. SAA had the most significant correlation with BVAS (r=0.63, p

Özet

Amaç: Vaskülitlerin takibinde ideal biyobelirteç için hala karşılanmamış ihtiyaçlar vardır. Bu çalışmada S100A12 ve Serum Amilod A’nın (SAA) vaskülitlerin tanı veya hastalık aktivasyonunda biyobelirteç olarak geçerliliklerini değerlendirmeyi amaçladık. Yöntem: Klinik olarak aktif 18 vaskülit hastası [dev hücreli arterit (n=6), Takayasu arteriti (n=6) ve granülomatoz polianjit (n=6)] ve 12 sağlıklı kontrol çalışmaya dahil edildi. Hastalık aktivitesi Birmingham hastalık aktivite skoru (BVAS) kullanılarak değerlendirildi. SAA, S100A12, C-reaktif protein (CRP), nötrofil-lenfosit oranı (NLR), trombosit-lenfosit oranı (PLR) ve BVAS arasındaki korelasyon araştırıldı. Her biyobelirteçin tanısal geçerliliğini değerlendirmek için alıcı işlem karakteristiklerinin analizi yapıldı. Bulgular: Aktif vaskülitli hastalarda, sağlıklı kontrollere kıyasla CRP, S100A12 ve SAA düzeyleri ile NLR ve PLR oranları anlamlı derecede yüksek saptandı. S100A12, hastalık aktivitesi ve diğer biyobelirteçler ile korele değildi. Hastalık aktivitesi ile en anlamlı korelasyona SAA’nın sahip olduğu saptandı (r=0,63, p

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Cite This Article

BABAOĞLU, H. (2022). Serum amyloid A may be a potential biomarker for vasculitis. Ulusal Romatoloji Dergisi, Cilt: 14 - Sayı: 2, 100–105. https://ajindex.com/articles/655399

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