SavedAdd your journal

Journals / Türk Oftalmoloji Dergisi / 2009 / Cilt: 39 - Sayı: 4

Clear lens extraction in alport’s syndrome patient with anterior and posterior lenticonus

Anterior ve posterior lentikonuslu alport sendromlu hastada şeffaf lens cerrahisi

Mehmet Akif ACAR
Özlem Yalçın TÖK
Gökhan BAVLI
Muhammet Necati DEMİR
Firdevs ÖRNEK
Pages
320–323
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

He had developed end-stage renal failure which required hemodialysis for three years.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Alports syndrome is a hereditary disease characterized by progressive nephritis, sensorineural hearing loss and ocular abnormalities.
📊
Key Findings & Data:A 36 years-old man was applied to ophthalmology department with a complaint of decreased visual acuity in both eyes.
💡
Conclusion & Impact:He had developed end-stage renal failure which required hemodialysis for three years.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Alports syndrome is a hereditary disease characterized by progressive nephritis, sensorineural hearing loss and ocular abnormalities. A 36 years-old man was applied to ophthalmology department with a complaint of decreased visual acuity in both eyes. His history included deafness and renal disease since childhood. On ocular examination, the best corrected Snellen visual acuity was 1/10 in both eyes. Slitlamp biomicroscopy examination revealed anterior and posterior lenticonus in both eyes. Retinal flecks a spare of bilateral perimacular areas were detected on fundoscopy. On systemic examination, sensorineural hearing loss was detected by audiometry. He had developed end-stage renal failure which required hemodialysis for three years.

Özet

Alport Sendromu ilerleyici nefrit, sensorinöral işitme kaybı ve oküler bozukluklarla seyreden herediter bir hastalıktır. 36 yaşında erkek hastalar iki gözünde görme azlığı ile polikliniğimize başvurdu. Hastanın hikayesinde çocukluğundan beri işitme kaybı, böbrek rahatsızlığı vardı. Oküler muayenesinde sağ ve sol gözde düzeltilmiş en iyi görme keskinliği Snellen eşelinde 1/10 idi. Biyomikroskopik muayanede bilateral anterior ve posterior lentikonus saptandı. Fundus muayenesinde bilateral perimakuler yerleşimli beneklenmeler görüldü. Sistemik muayenede, işitme testinde sensörinöral işitme kaybı tespit edildi. Hasta son dönem böbrek yetmezliği nedeniyle üç yıldır hemodiyalize giriyordu. Bu bulgular ışığında hastaya Alport scndromu tanısı kondu. Hastanın iki gözüne bir hafta arayla fakoemülsifikasyon ile şeffaf lens cerrahisi ve kapsül içine katlanır üç parçalı hidrofobik akrilik göz içi lensi (GİL) yerleştirildi. 1 senelik takibinde hastanın myopik düzeltme ile en iyi görme keskiniği Snellen eşelinde 10/10 idi ve GİL pozisyonu santralize idi.Anterior ve posterior lentikonuşlu Alport sendromunda hızlı görsel rehabilitasyon için fakoemülsifikasyon ve GİL implantasyonu etkili ve güvenli bir yöntemdir.

🔖

Cite This Article

ACAR, M. A., TÖK, Ö. Y., BAVLI, G., DEMİR, M. N., ÖRNEK, F. (2022). Clear lens extraction in alport’s syndrome patient with anterior and posterior lenticonus. Türk Oftalmoloji Dergisi, Cilt: 39 - Sayı: 4, 320–323. https://ajindex.com/articles/638491

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (18)

  1. Mavrikakis I. Zeilmaker C. Wearne MJ. Surgical management of anterior lenticonus in Alport's syndrome. Eye 2002 Nov;l6(6):798-800
  2. Barker DF, Hostikka SL. Zhou J. Chow LT. Oliphani AR. Gerken SC, et al. Identification of mutations in the COL4A5 collagen gene in Alport syndrome. Science 1990;248:1224-7
  3. Mariyama M, Kalluri R. Hudson BG. Reeders ST. The a4(IV) chain of basement membrane collagen: isolation of cDNA encoding bovine a4(IV) and comparison with other type IV collagen. J Biol Chem 1991:267:1253-8
  4. Choi J. Na K, Bae S, Roh G. Anterior lens capsule abnormalities in Alport syndrome. Korean J Ophthalmol 2005: 19:84-89
  5. Nielsen CE. Lenticonus anterior and Alport's disease. Am J Ophthalmol 1977;84:532-5
  6. Govan JA. Ocular manifestations of Alport s syndrome: a hereditary disorder of basement membrane. Br J Ophthalmol 1983:67:493-503
  7. Junk AK, Stefani FH. Ludwig K. Bilateral anterior lenti-conus; Scheimpflug imaging system documentation and ultrastructural confirmation of Alport syndrome in the lens capsule. Arch Ophthalmol 2000: 118:895-897
  8. Nielsen CE. Lenticonus anterior and Alport's syndrome. Acta Ophthalmol 1978: 56:518-530
  9. Vedantham V, Rajagopal J. Ratnagiri PK. Bilateral simultaneous anterior and posterior lenticonus in Alport's syndrome. Indian J Ophthalmol 2005; 53:212-213
  10. Sukhija J, Saini JS. Jain AK. Phacoemulsification and intraocularlens implantation in an Alport's syndrome patient with bilateral anterior and posterior lenticonus. J Cataract Refract Surg 2003; 29:1834-1836
  11. Alport AC. Hereditary- familial congenital hacmorrhagic nephritis. BMJ 1927; 1:504-6
  12. Colville DJ. Savige J. Alport syndrome; a review of the ocular manifestations. Ophthalmic Genet 1997; 18:161-173
  13. MA Zarc. MD, MT Rajabi. MD. MN Ahmadabadi, MD. SJ Oskouce. MD. S Moghimi. MD. Phacoemulsification and intraocular lens implantation in Alport syndrome with antcrior lenticonus. J Cataract Refractive Surgery 2007; 33:1127-1130
  14. Olitsky SE, Waz WR. Wilson ME. Rupture of the anterior lens capsule in Alpoit's syndrome. J AAPOS 1999: 3: 381-382
  15. Kato T, Watanabe Y. Nakayasu K et al. The ultrastructure of the lens capsule abnormalities in Alport's syndrome. Jpn Journal Ophtalmology 1998; 42: 401-405
  16. Khalil M, Saheb N. Posterior lenticonus. Ophthalmology 1984;91:1429-1430.43A
  17. Çıtırık M. Men G. Özkan SS. Özdür C. Aslan Ö. Bir olgu nedeniyle Alport sendromu. T Klin Oftalmoloji 2002; 11: 219-223
  18. Yıldırım C, Yakut E. Al