Journals / Türk Oftalmoloji Dergisi / 2013 / Cilt: 43 - Sayı: 4

Amniotic membrane transplantation in herpetic keratitis and bacterial keratitis

Herpetik keratit ve bakteriyel keratitlerdemembran transplantasyonu amniyotik

Pages
229–235
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although visual acuities improved significantly in both groups, this improvement was more evident in BK cases (p=0.018 for HK and p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Pur­po­se: To evaluate the effect of amniotic membrane transplantation (AMT) in the treatment of corneal ulcers resulting from her- petic keratitis (HK) and bacterial keratitis (BK).
📊
Key Findings & Data:Ma­te­ri­al and Met­hod: Forty-six patients (25 HK, 21 BK) treated with AMT for HK or BK-related corneal ulcers between January 2009 and September 2011 were followed prospectively.
💡
Conclusion & Impact:Although visual acuities improved significantly in both groups, this improvement was more evident in BK cases (p=0.018 for HK and p
🔬Design:Research Article
📍Scope:2009 Verileri
⚙️Variables:Domain Parameters

Abstract

Pur­po­se: To evaluate the effect of amniotic membrane transplantation (AMT) in the treatment of corneal ulcers resulting from her- petic keratitis (HK) and bacterial keratitis (BK). Ma­te­ri­al and Met­hod: Forty-six patients (25 HK, 21 BK) treated with AMT for HK or BK-related corneal ulcers between January 2009 and September 2011 were followed prospectively. The visual acuities and ulcer characteristics (depth and localization) prior to AMT and epithelialization time, as well as final visual acuities after AMT, were evaluated. Re­sults: The mean age was 51.9±17.0 years in HK and 53.3±22.0 years in BK and the mean follow-up time was 12.6±6.1 (5-33) months and 10.2±6.8 (3-27) months, respectively. The ulcers were mostly central in HK (72%) and paracentral in BK (52.4%) (p=0.03). Ulcer depth was deeper than 1/2 of the cornea in 14 (56%) HK and in 7 (33.3%) BK (p=0.290). Eight HK patients had scars from previous herpetic keratitis episodes. The mean epithelialization time was 22.3±8.5 (12-50) days in HK and 22.1±10.9 (8-45) days in BK (p=0.488). While epithelialization was achieved in all the patients with BK, 3 HK patients needed adjunctive surgeries (conjunctival flap, tectonic penetrating keratoplasty) in spite of three AMTs. Although visual acuities improved significantly in both groups, this improvement was more evident in BK cases (p=0.018 for HK and p

Özet

Amaç: Herpetik keratit (HK) ve bakteriyel keratit (BK) sonucu gelişen korneal ülserlerin tedavisinde amniyotik membran transplan- tasyonunun (AMT) etkinliğini değerlendirmek. Ge­reç ve Yön­tem: Ocak 2009-Eylül 2011 tarihleri arasında herpetik ve bakteriyel keratite bağlı korneal ülser nedeniyle AMT yapılan 46 göz (25 HK, 21 BK) prospektif olarak incelendi. Hastaların AMT öncesi görme keskinliği ve ülserin nitelikleri (derinliği, yerleşimi), AMT sonrası epitelizasyon zamanı ve sonuç görme keskinliği değerlendirildi. So­nuç­lar: Ortalama yaş HKli olgularda 51,9±17,0, BKli olgularda 53,3±22,0 yıl ve ortalama takip süresi sırasıyla 12,6±6,1 (5-33) ve 10,2±6,8 (3-27) ay idi. Ülser HKde daha çok santral (%72,0), BKde ise parasantral (%52,4) yerleşimliydi (p=0,030). Ülser derinliği HKde 14 (%56,0), BKde 7 (%33,3) olguda korneanın 1/2sinden fazla idi (p=0,290). Herpetik keratitli olguların 8inde daha önce geçirilmiş herpetik keratite bağlı korneal skar mevcuttu. Ortalama epitelizasyon zamanı HKde 22,3±8,5 (12-50), BKde 22,1±10,9 (8-45) gün idi (p=0,488). Bakteriyel keratitli olguların tamamında AMT ile epitelizasyon sağlanırken HKli 3 olguda 3 kez AMTye rağmen ülser kapanmadı ve ek cerrahiler (konjonktiva örtmesi, tektonik penetran keratoplasti) uygulandı. Her iki grupta da AMT sonrası görme keskinliğinde istatistiksel olarak anlamlı artış saptanmakla birlikte (HK; p=0,018 ve BK; p=

🔖

Cite This Article

ERASLAN, E. Y., YALNIZ, Z. A., ÖRNEK, F., BURCU, A. (2022). Amniotic membrane transplantation in herpetic keratitis and bacterial keratitis. Türk Oftalmoloji Dergisi, Cilt: 43 - Sayı: 4, 229–235. https://ajindex.com/articles/638171

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Slansky HH, Dohlman CH, Berman MB. Prevention of corneal ulcers. Trans Am Acad Ophthalmol Otolaryngol. 1971;75:1208-11.
  2. Kim JS, Kim JC, Hahn TW, Park WC. Amniotic membrane transplantation in infectious corneal ulcer. Cornea. 2001;20:720-6.
  3. Ma DH-K, Wang SF, Su WY, Tsai RJ. Amniotic membrane graft for the management of scleral melting and corneal perforation in recalcitrant infectious scleral and corneoscleral ulcers. Cornea. 2002;21:275-83.
  4. Gicquel JJ, Bejjani RA, Ellies P, Mercié M, Dighiero P. Amniotic membrane transplantation in severe bacterial keratitis. Cornea. 2007;26:27-33. De Rotth A. Plastic repair of conjunctival defects with fetal membranes. Arch Ophtalmol. 1940;23:522-5.
  5. Hao Y, Ma DH, Hwang DG, Kim WS, Zhang F. Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane. Cornea. 2000;19:348-52.
  6. Tseng SC, Li DQ, Ma X. Suppression of transforming growth factor-beta isoforms, TGF-beta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix. J Cell Physiol. 1999;179:325-35.
  7. Ni J, Abrahamson M, Zhang M, et al. Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins. J Biol Chem. 1997;272:10853-8.
  8. Talmi WP, Sigler L, Inge E, Finkelstein Y, Zohar Y. Antibacterial properties of human amniotic membranes. Placenta. 1991;12:285-8.
  9. Kjaergaard N, Hein M, Hyttel L, et al. Antibacterial properties of human amnion and chorion in vitro. Eur J Obstet Gynecol Reprod Biol. 2001;94:224- 9. Sippel KC, Foster CS. Three pearls in amniotic membrane grafting. In: Melki SA and Azar DT, eds. 101 Pearls in Refractive, Cataract and Corneal Surgery, Thorafare, NJ: SLACK, Inc, 2001. p.125-30.
  10. Kim JS, Kim JC, Na BK, Jeong JM, Song CY. Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acute corneal alkali burn. Exp Eye Res. 2000;70:329-37.
  11. Shimmura S, Shimazaki J, Ohashi Y, Tsubota K. Antiinflammatory effects of amniotic membrane transplantation in ocular surface disorders. Cornea. 2001;20:408-13.
  12. Heiligenhaus A, Meller D, Meller D, Steuhl K-P, Tseng SCG. Improvement of HSV-1 necrotizing keratitis with amniotic membrane transplantation. Invest Ophthalmol Vis Sci. 2001;42:1969-74.
  13. Heiligenhaus A, Li H, Hernandez Galindo EE, Koch JM, Steuhl KP, Meller D. Management of acute ulcerative and necrotising herpes simplex and zoster keratitis with amniotic membrane transplantation