AI Summary & Key Takeaways
AI InsightThe mean preoperative SMH duration was significantly shorter in patients who achieved total resolution of the hemorrhage compared with the subtotal resolution group (p
📌 3 Key Takeaways
Abstract
Objectives: To evaluate the functional and morphological outcomes of vitrectomy in combination with intravitreal 5% C3F8 tamponade and subretinal injections of tissue plasminogen activator (tPA) and anti-vascular endothelial growth factor (anti-VEGF) in patients with submacular hemorrhage (SMH) and to investigate the preoperative prognostic factors. Materials and Methods: This retrospective study included 30 patients (16 women, 14 men) diagnosed with SMH secondary to neovascular age-related macular degeneration (AMD). Preoperative SMH thickness and area, ellipsoid zone integrity, and postoperative reduction in the amount of subfoveal blood on optical coherence tomography and fundus photographs were assessed. Furthermore, visual acuity (VA), hemorrhage duration, and the need for additional intravitreal anti-VEGF injections were recorded. Results: The patients’ mean age was 73.33±8.23 years. Mean VA improved from logMAR 2.11±0.84 at baseline to logMAR 1.32±0.91, 0.94±0.66, 1.13±0.84, and 1.00±0.70 at postoperative month 1, 2, 3, and 6, respectively. A significant negative correlation was found between hemorrhage duration and postoperative VA at month 2 (p=0.005), month 3 (p=0.019), and month 6 (p=0.012). The mean preoperative SMH duration was significantly shorter in patients who achieved total resolution of the hemorrhage compared with the subtotal resolution group (p
Özet
Amaç: Submaküler hemoraji (SMH) tanılı hastalarda, vitrektomi ile kombine subretinal doku plazminojen aktivatörü (tPA) ve antivasküler endotelyal büyüme faktörü (anti-VEGF) eşliğinde %5 C3F8 gaz tamponad cerrahisinin fonksiyonel ve morfolojik sonuçları yanı sıra preoperative prognostic faktörleri değerlendirmektir. Gereç ve Yöntem: Retrospektif çalışmamıza, yaşa bağlı maküla dejenerasyonuna (YBMD) sekonder SMH tanılı 30 hasta (16 kadın, 14 erkek) dahil edildi. Preoperatif SMH kalınlığı ve alanı, elipsoid zonun durumu yanı sıra postoperatif optik koherens tomografide subfoveal hemoraji miktarındaki azalma ve fundus fotoğrafları değerlendirildi. Ayrıca görme keskinliği (GK), hemorajinin süresi ve ek intravitreal anti-VEGF enjeksiyon ihtiyacı kaydedildi. Bulgular: Hastaların ortalama yaşı 73,33±8,23 idi. Ortalama GK logMAR 2,11±0,84’ten postoperatif 1. ayda logMAR 1,32±0,91, 2. ayda 0,94±0,66, 3. ayda 1,13±0,84 ve 6. ayda 1,00±0,70’e yükseldi. Hemorajinin süresi ile postoperatif 2. ay (p=0,005), 3. ay (p=0,019) ve 6. ay (p=0,012) GK’leri arasında anlamlı negatif korelasyon mevcuttu. Postoperatif total hemoraji rezolüsyonu elde edilen grupta SMH süresi subtotal rezolüsyon grubuna kıyasla anlamlı olarak kısaydı (p