The effect of blood pressure regulation on choroidal thickness

Objective & Hypothesis:Purpose: To assess the effects of the blood pressure regulation on the choroidal thickness of newly diagnosed hypertension patients.

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Key Findings & Data:Materials and Methods: The study consisted of 65 eyes of 65 (33 males and 32 females) newly diagnosed hipertension patients.

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Conclusion & Impact:This may be related to regulation of ocular blood flow via sympathetic innervation and autoregulation.

🔬Design:Research Article

📍Scope:2000 Verileri

⚙️Variables:Domain Parameters

Abstract

Purpose: To assess the effects of the blood pressure regulation on the choroidal thickness of newly diagnosed hypertension patients. Materials and Methods: The study consisted of 65 eyes of 65 (33 males and 32 females) newly diagnosed hipertension patients. The choroid was imaged using enhanced depth imaging spectral domain optical coherence tomography (3D OCT- 2000, Topcon Corp., Tokyo, Japan). First OCT measurements were performed before treatment and second were obtained 1 month after strarting antihypertensive treatment. Choroidal thickness was measured at seven different points by two masked graders and the average value was used for analysis. The data were analyzed using paired t test. Results: The mean age was 50.0±8.8 years (range, 45-59 years). The mean systolic blood pressure was 181.4±22.6 mm Hg before and 123.7±11.8 mm Hg after antihypertensive treatment. The mean choroidal thickness before treatment was 244.1±41.2 μm and 237.8±69.8 μm at first month after therapy. There was no statistically significance between mean cho- roidal thickness measurements before and after antihypertensive treatment (p=0.590) Conclusion: The mean choroidal thickness does not change after blood pressure regulation in hypertensive patients. This may be related to regulation of ocular blood flow via sympathetic innervation and autoregulation.

Özet

Amaç: Yeni tanı almış hipertansif hastaların kan basınıcı regülasyonun koroid kalınlığına etkisinin değerlendirilmesi. Gereç ve Yöntem: Çalışmaya yeni hipertansiyon tanısı almış 65 hastanın (33 erkek, 32 kadın) 65 gözü dahil edildi. Koroi- din görüntülenmesi spectral domain OKT (3D OCT-2000, Topcon Corp., Tokyo, Japan) ile artırılmış derinlikli görüntüleme modu kullanılarak yapıldı. Hastalara tedavi öncesi ve antihipertansif tedavi başlandıktan 1 ay sonra ölçüm yapıldı. Yedi farklı noktada koroid kalınlığı ölçümü yapıldı. Koroid kalınlığı ölçümü birbirinden habersiz iki kişi tarafından yapılarak ortalaması alındı. İstatistiksel analiz için ortalama değer kullanıldı. İstatistiksel değerlendirme bağımlı gruplar için t testi kullanılarak yapıldı. Bulgular: Çalışmaya alınan hastaların ortalama yaşı 50.2±8.8 yıl (yaş aralığı, 45-59 yıl) idi. Hastaların ortalama sistolik kan basınçları tedavi öncesi 181.4±22.6 mm Hg tedavi sonrası 123.7±11.8 mm Hg düzeyindeydi (p=0.001). Ortalama koroid kalınlığı tedavi öncesi 244.1±41.2 μm, kan basıncının regüle olduğu 1.ayda 237.8±69.8 μm olarak bulundu. Aradaki fark istatistiksel olarak anlamlı değildi.(p=0.590) Sonuç: Ortalama koroid kalınlığı kan basıncındaki düşüşe karşı değişim göstermemektedir. Sempatik inervasyon ve otore- gülasyon mekanizmaları ile bunu sağladığı düşünülmektedir.

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Cite This Article

ZENGİN, M. Ö., KARAHAN, E., ÖZYURTLU, F., Tuncer, İ., PEKEL, N., ÇINAR, E., KÜÇÜKERDÖNMEZ, C. (2014). The effect of blood pressure regulation on choroidal thickness. Retina-Vitreus, Cilt: 22 - Sayı: 3, 213–216. https://ajindex.com/articles/305018

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