Journals / Türk Klinik Biyokimya Dergisi / 2015 / Cilt: 13 - Sayı: 1

Beta Thalassemia Trait Accompanying Iron Deficiency Anemia

Beta Talasemi Taşıyıcılığına Eşlik Eden Demir Eksikliği Anemisi

Pages
29–34
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Especially in female and child beta thalassemia carriers, it should be taken into account the possible togetherness with the iron deficiency during the treatment period

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Anemia is a commonly encountered health problem.
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Key Findings & Data:Material and Methods: The 128 specimens of whole blood samples (n = 895) that were sent to our laboratory were selected as beta thalassemia carriers by hematological indices and HbA2 values.
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Conclusion & Impact:Conclusion: Especially in female and child beta thalassemia carriers, it should be taken into account the possible togetherness with the iron deficiency during the treatment period
🔬Design:Review & Systematic Survey
📍Scope:128 specimens
⚙️Variables:Domain Parameters

Abstract

Objective: Anemia is a commonly encountered health problem. In this study, togetherness of beta thalassemia trait with iron deficiency anemia was investigated using by some biochemical and hematological cell count indices. Material and Methods: The 128 specimens of whole blood samples (n = 895) that were sent to our laboratory were selected as beta thalassemia carriers by hematological indices and HbA2 values. The hemoglobin chain analysis was performed by high performance liquid chromatography method. Complete blood count, serum iron, total iron binding capacity, serum ferritin level, Mentzer Index and transferrin saturation index were retrospectively evaluated. Results: In all carriers included in the review, 63 % were females, 23 % were men and 14 % were children under the age of 16. Although low ferritin levels were observed in only one carrier of each men and children group, in female carriers this was found as 28 %. Mentzer Index was found higher than 13 in 20 % of female, 3 % of men and 6 % of children carriers. Transferrin saturation index was found lower than 10 % in 14 % of female, 10 % of men and 11 % of children carriers groups. Conclusion: Especially in female and child beta thalassemia carriers, it should be taken into account the possible togetherness with the iron deficiency during the treatment period

Özet

Amaç: Anemi sıklıkla karşılaşılan bir halk sağlığı problemidir. Bu çalışmada beta talasemi taşıyıcılığında demir eksikliği anemisinin birlikteliği bir takım biyokimyasal ve hematolojik indeksler kullanılarak araştırıldı. Gereç ve Yöntem: Laboratuvarımıza gönderilen numuneler içinden (n = 895) hematolojik indeksler ve HbA2 değerlerine göre beta talassemi taşıyıcısı olan 128 tam kan numunesi seçildi. Hemoglobin zincir analizi yüksek basınçlı sıvı kromatografisi metodu ile çalışıldı. Tam kan sayımı, serum demir, total demir bağlama kapasitesi, serum ferritin düzeyi, Mentzer İndeksi ve transferrin saturasyon indeksi geriye dönük olarak değerlendirildi. Bulgular: Değerlendirmeye alınan tüm taşıyıcıların; % 63'ü kadın, % 23'ü erkek ve % 14'ü 16 yaş altı çocuktu. Ferritin düzeyi düşüklüğü erkeklerde ve çocuk yaş grubunda sadece birer taşıyıcıda görülmesine rağmen kadın taşıyıcılarda bu oran % 28'di. Kadın taşıyıcıların % 20'sinin, erkek taşıyıcılarının % 3'ünün ve çocuk yaş grubu taşıyıcıların % 6'sının Mentzer İndeksi 13'ün üzerinde bulundu. Kadın taşıyıcıların % 14'ünde, erkek taşıyıcıların % 10'unda, çocuk yaş grubu taşıyıcıların % 11'inde transferrin saturasyon indeksi % 10'un altında saptandı. Sonuç: Özellikle erişkin kadın ve çocuk beta talasemi taşıyıcılarının tedavisi sırasında demir eksikliğinin de birlikte olabileceği göz önünde bulundurulmalıdır

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Cite This Article

AKSUN, S., SÜTÇÜ, R., SÖĞÜT, E., ATAY, A., DEMİR, L., ÜNALİ, H. (2022). Beta Thalassemia Trait Accompanying Iron Deficiency Anemia. Türk Klinik Biyokimya Dergisi, Cilt: 13 - Sayı: 1, 29–34. https://ajindex.com/articles/634434

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