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Journals / Türk Klinik Biyokimya Dergisi / 2017 / Cilt: 15 - Sayı: 2

Bir Üniversite Hastanesinde Hemoglobinopati ve Talasemi Verilerinin Değerlendirilmesi

Assessment of Data Regarding Thalassemias and Hemoglobin Variants From a Tertiary Referral Hospital Laboratory in Turkey

Mehmet AKÖZ
Saliha UYSAL
Nejla ÖZER
Merve Sibel GÜNGÖREN
Tevfik BALCI
Pages
52–66
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: 668 results with HbA2>3.5% and 19 results with 3.5%< HbA2 2% and 138 of them with HbA2

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Hemoglobinopathies are an array of disorders that affect hemoglobin (Hb) function.
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Key Findings & Data:The aim of this study is to evaluate 3-year retrospective data of a tertiary hospital in Turkey according to prevalence of hemoglobinopathies.Material and Methods: A three-year data of 2461 patients admitted to our university hospital laboratory were assessed by scanning laboratory and hospital records.
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Conclusion & Impact:Results: 668 results with HbA2>3.5% and 19 results with 3.5%< HbA2 2% and 138 of them with HbA2
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Hemoglobinopathies are an array of disorders that affect hemoglobin (Hb) function. HPLC is by far the most common technique used for detection of hemoglobinopathies worldwide. The aim of this study is to evaluate 3-year retrospective data of a tertiary hospital in Turkey according to prevalence of hemoglobinopathies.Material and Methods: A three-year data of 2461 patients admitted to our university hospital laboratory were assessed by scanning laboratory and hospital records. Tosoh G8 HPLC instrument was used for screening. Results: 668 results with HbA2>3.5% and 19 results with 3.5%< HbA2 2% and 138 of them with HbA2

Özet

Amaç: Hemoglobinopatiler, globin fonksiyonlarını bozan bir grup hastalıktır. HPLC, hemoglobinopati taramalarında tüm dünyada en sık kullanılan tekniktir. Çalışmada, Türkiye'de bir üçüncü basamak hastane laboratuvarında 3 yıllık retrospektif hemoglobinopati sıklığı değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Üniversite hastanemize başvuran 2461 hastanın 3 yıllık laboratuvar ve hastane kayıtları incelenmiştir. Hemoglobinopati taramasında Tosoh G8 HPLC cihazı kullanılmıştır Bulgular: HbA2>%3,5 olan 668, %3,5%2 olan 391 hasta saptanmış ve HbA2

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Cite This Article

AKÖZ, M., UYSAL, S., ÖZER, N., GÜNGÖREN, M. S., BALCI, T. (2022). Bir Üniversite Hastanesinde Hemoglobinopati ve Talasemi Verilerinin Değerlendirilmesi. Türk Klinik Biyokimya Dergisi, Cilt: 15 - Sayı: 2, 52–66. https://ajindex.com/articles/634392

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References (10)

  1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010; 33(1): 62-9
  2. Nathan DM, Davidson MB, DeFronzo RA, et al, for the American Diabetes Association. Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care 2007; 30: 753– 59
  3. Abdul-Ghani MA, Tripathy D, DeFronzo RA. Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care 2006; 29: 1130-1139
  4. Teegarden D, Donkin SS. Vitamin D: emerging new roles in insulin sensitivity. Nutr Res Rev 2009; 22: 82-92
  5. Muszkat P, Camargo MB, Griz LH, Lazaretti-Castro M. Evidence-based non-skeletal actions of vitamin D. Arq Bras Endocrinol Metabol 2010; 54: 110-117
  6. Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E. Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus. DiabetesResearch and Clinical Practice 1995; 27(3): 181–18 7. Baynes KCR, Boucher BJ, Feskens EJM, Kromhout D. Vitamin D, glucose tolerance anal insulinaemia in elderly men. Diabetologia 1997; 40(3): 344–347
  7. Scragg R, Sowers M, Bell C. Serum 25- hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004; 27(12): 2813–2818
  8. Chertow BS, Sivitz WI, Baranetsky NG, Clark SA, Waite A. Cellular mechanisms of insulin release: the effects of vitamin D deficiency and repletion on rat insulin secretion. Endocrinology 1983, 113:1511– 1518
  9. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care 2007; 30(4): 980-6 11. von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insülin resistance in South Asian Women living New Zealand who are insülin resistant and vitamin D deficient-a randomised, placebo-controlled trial. Br J Nutr 2010; 103: 549-555 12. de Courten B, Mousa A, Naderpoor N, Teede H, de Courten MP, Scragg R. Vitamin D supplementation for the prevention of type 2 diabetes in overweight adults: study protocol for a randomized controlled trial. Trials. 2015 Aug 7;16:335
  10. Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. Diabetologia 2005;48(7): 1247-1257 14. Ogunkolade BW, Boucher BJ, Prahl JMet, al. Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D