SavedAdd your journal

Journals / Türkiye Diyabet ve Obezite Dergisi / 2021 / Cilt: 5 - Sayı: 1

Asprosin and Effects on Glucose Metabolism

Asprosin ve Glikoz Metabolizması Üzerine Etkileri

Nurhan ÜNÜSAN
M. Gizem KESER
Pages
89–95
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study was aimed to investigate the relationship between asprosin and some public health problems such as obesity and type 2 diabetes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Adipokines secreted from adipose tissue, are bioactive substances and have kinds of functions on appetite, energy, lipid, carbohydrate metabolism, regulation of blood pressure, inflammation, etc.
📊
Key Findings & Data:One of the adipokines is asprosin discovered in 2016, is secreted by white adipose tissue.
💡
Conclusion & Impact:This study was aimed to investigate the relationship between asprosin and some public health problems such as obesity and type 2 diabetes.
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:asprosin · diyabet · obezite

Abstract

Adipokines secreted from adipose tissue, are bioactive substances and have kinds of functions on appetite, energy, lipid, carbohydrate metabolism, regulation of blood pressure, inflammation, etc. One of the adipokines is asprosin discovered in 2016, is secreted by white adipose tissue. This is released during fasting and found in circulating nanomolar levels. Asprosin is encoded by two exons of the gene FBN1 and is known for its effects on many metabolic processes, especially glucose metabolism, and is still under investigation. This study was aimed to investigate the relationship between asprosin and some public health problems such as obesity and type 2 diabetes.

Özet

Adipokinler adipoz dokudan salgılanan bioaktif maddeler olup iştah, enerji, lipid, karbonhidrat metabolizması, kan basıncının düzenlenmesi ve inflammasyon üzerinde çeşitli fonksiyonlara sahiptir. Bunlardan biri de 2016 yılında keşfedilen ve beyaz adipoz dokudan salgılanan asprosindir. Asprosin, açlık süresince salınmakta ve nanomolar düzeyde sirküle olmaktadır. FBN1 geninin iki egzonu tarafından kodlanan asprosinin, glikoz metabolizması gibi bazı metabolik süreçlerde doğrudan etkili olduğu bilinmekte ve halen araştırılmaktadır. Bu çalışma, asprosin ile obezite ve tip 2 diyabet gibi bazı halk sağlığı sorunları arasındaki ilişkiyi araştırmayı amaçlamıştır.

🔖

Cite This Article

ÜNÜSAN, N., KESER, M. G. (2022). Asprosin and Effects on Glucose Metabolism. Türkiye Diyabet ve Obezite Dergisi, Cilt: 5 - Sayı: 1, 89–95. https://ajindex.com/articles/627883

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Romere C, Duerrschmid C and Bournat J et al. Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell. 2016; 165(3): 566-579.
  2. Li E, Shan H, Chen L, Long A, Zhang Y and Liu Y et al. OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin. Cell Metabolism. 2019; 30: 319–328.
  3. Duerrschmid C, He Y, Wang C, Li C, Bournat JC and Romere C et al. Asprosin is a centrally acting orexigenic hormone. Nature Medicine. 2017; 23, 1444–1453. Öztürk Andaç S. Besin Alımının Düzenlenmesi. Özer C (Ed.), Diyet Çeşitlerine Bilimsel Bakış içinde, Akademisyen Kitapevi, 2020, 23-41. Meguid MM and Laviano A. Basics in clinical nutrition: appetite and its control. The European e-Journal of Clinical Nutrition and Metabolism. 2008; 3: 272-274. Yu JH and Kim MS. Molecular mechanisms of appetite. Regulation Diabetes Metab J. 2012;36 (6):391-398. Ahima RS and Flier JS. Leptin. Annual Review of Physiol. 2000; 62: 413-437.
  4. Sinha MK, Ohannesian JP, Heiman ML, Kriauciunas A, Stephens TW and Magosin S et al. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. Journal of Clinical Investigation. 1996; 97(5): 1344–1347.
  5. Licinio J, Mantzoros C, Negrão AB, Cizza G, Wong ML and Bongiorno PB. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nature Medicine. 1997; 3(5):575-9.
  6. Martin R, Cordova C, Gutierrez B, Hernandez M, Nieto ML. A dangerous liaison: Leptin and Spla2-IIA join forces to induce proliferation and migration of astrocytoma cells. PLoS One. 2017;12(3):0170675. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE and Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001;50(8):1714-9.
  7. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999; 402: 656–660.
  8. Segal-Lieberman G, Rubinfeld H, Glick M, Kronfeld-Schor N and Shimon I. Melanin-concentrating hormone stimulates human growth hormone secretion: a novel effect of MCH on the hypothalamic-pituitary axis. American Journal of Physiology-Endocrinology and Metabolism. 2006; 290: 982–988.
  9. Holzer P, Reichmann F and Farzi A. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides. 2012;46(6):261-74.
  10. Kose S, Gulec MY, Ozalmete OA, Ozturk M, Gulec H and Sayar K. Plasma neuropeptide Y levels in medication naive adolescents with major depressive disorder. Klinik Psikofarmakol