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Journals / Akdeniz Tıp Dergisi / 2026 / Cilt: 12 Sayı: 1

The Role of Some Foods and Other Factors on The Attacks In Patients with FMF: A Cross-Sectional Study

Bazı Besinlerin ve Diğer Faktörlerin FMF'li Hastalarda Ataklar Üzerindeki Rolü: Kesitsel Bir Çalışma

Muteber Gizem Keser Gümüş(KTO KARATAY UNIVERSITY)0000-0001-9425-9088
İrem Alaçık Develioğlu(KTO KARATAY UNIVERSITY)0000-0002-4698-3191
Nurhan Ünüsan(KTO KARATAY UNIVERSITY)0000-0002-7445-6903
Pages
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Publication Date
2026-03-04
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

More detailed studies with larger sample sizes are needed to elucidate the relationship between diet and FMF attacks.

📌 3 Key Takeaways

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Objective & Hypothesis:ABSTRACT Objective: Familial Mediterranean fever (FMF) is an inflammatory disease inherited in autosomal recessive patterns.
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Key Findings & Data:Material and Methods: An online questionnaire was administered to patients form between January 2023 and April 2023 through the internet.
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Conclusion & Impact:More detailed studies with larger sample sizes are needed to elucidate the relationship between diet and FMF attacks.
🔬Design:Survey & Empirical Study
📍Scope:2023 Verileri
⚙️Variables:Ailesel Akdeniz ateşi · Diyet · Gıda

Abstract

ABSTRACT Objective: Familial Mediterranean fever (FMF) is an inflammatory disease inherited in autosomal recessive patterns. This cross-sectional study aimed to elucidate whether some food groups and environmental factors trigger attacks in FMF patients. Material and Methods: An online questionnaire was administered to patients form between January 2023 and April 2023 through the internet. Only FMF patients were included in the study. A questionnaire was developed by researchers examining food groups in terms of attack stimulation as increasing, decreasing, or not changing. Data analysis was performed with SPSS, version 24. Results: The mean age of 113 patients with FMF was 35,44±15,38, 55.8% of them (n= 63) were female and 44.2% of them were male (n=50). In all food groups, patients using medication with FMF state that the most prominent attacks increasing foods were respectively; Carbonated beverages (61.10%), packaged foods (cake, chocolate, chips) (49.60%), and legumes (38.10%). When patients using medication were evaluated, there was a relationship between some of the food groups and gender. These groups were milk, oilseeds, acidic fruits, sulfurous vegetables (cabbage, cauliflower, etc.), legumes and carbonated beverages. In terms of age at disease onset, while significance was found cold weather in drug-using patients, yogurt, ayran, kefir and carbonated beverages were significantly related in non-drug users. Conclusions: Diet is the most prominent risk factor for progressing diseases. More detailed studies with larger sample sizes are needed to elucidate the relationship between diet and FMF attacks.

Özet

ÖZ Amaç: Ailevi Akdeniz ateşi (FMF), otozomal resesif kalıtımla geçen bir inflamatuar hastalıktır. Bu kesitsel çalışma, bazı yiyecek gruplarının ve çevresel faktörlerin FMF hastalarında atakları tetikleyip tetiklemediğini açıklamayı amaçlamıştır. Gereç ve Yöntemler: Bu çalışmada hastalara Ocak 2023 ile Nisan 2023 tarihleri arasında internet üzerinden çevrimiçi bir anket formu uygulanmıştır. Çalışmaya sadece FMF hastaları dahil edilmiştir. Araştırmacılar tarafından yiyecek gruplarının atak uyarımı açısından artan, azalan veya değişmeyen olarak incelendiği bir anket hazırlanmıştır. Veri analizi SPSS, sürüm 24 ile yapılmıştır. Bulgular: FMF tanılı 113 hastanın yaş ortalaması 35,44±15,38 olup, %55,8’i (n=63) kadın, %44,2’si (n=50) erkekti. Tüm besin grupları incelendiğinde, tıbbi ilaç kullanan FMF’li hastalar atakları en çok artıran besinlerin sırasıyla; Gazlı içecekler (%61,10), paketli gıdalar (kek, çikolata, cips) (%49,60) ve baklagiller (%38,10) olduğunu belirtmişlerdir. Tıbbi ilaç kullananlar incelendiğinde bazı besin grupları ile cinsiyet arasında ilişki olduğu görülmüştür. Bu gruplar süt, yağlı tohumlar, asitli meyveler, kükürtlü sebzeler (lahana, karnabahar vb.), baklagiller ve gazlı içeceklerdir. Hastalığın başlangıç yaşı açısından bakıldığında, ilaç kullanan hastalarda soğuk hava önemli bulunurken, ilaç kullanmayan hastalarda yoğurt, ayran, kefir ve gazlı içecekler anlamlı bulunmuştur. Sonuç: Diyet, progresif hastalıklar için en belirgin risk faktörüdür. Diyet ve FMF atakları arasındaki ilişkiyi açıklamak için daha ayrıntılı, daha büyük örneklemli çalışmalara ihtiyaç vardır.

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Cite This Article

Gümüş, M. G. K., Develioğlu, İ. A., Ünüsan, N. (2026). The Role of Some Foods and Other Factors on The Attacks In Patients with FMF: A Cross-Sectional Study. Akdeniz Tıp Dergisi, Cilt: 12 Sayı: 1. https://doi.org/10.53394/akd.1593308

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References (17)

  1. Tunca M, Ozdogan H. Molecular and genetic characteristics of hereditary autoinflammatory diseases. Curr Drug Targets Inflamm Allergy 2005; 4: 77-80.
  2. Portincasa P, Scaccianoce G, Palasciano G. Familial mediterranean fever: a fascinating model of inherited autoinflammatory disorder. Eur J Clin 2013; 43:1314-27.
  3. The International FMF Consortium. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 1997; 90:797-807.
  4. Cebicci H, Aykac Cebicci M, Sahan M, Gurbuz S, Karaca B, Karakus A, Tomruk Sutbeyaz S, Sunkak S. Triggers for attacks in familial mediterranean fever: Are there any regional or ethnic differences? Acta Med Mediterr 2014; 30:1349.
  5. Karadag O, Tufan A, Yazisiz V, Ureten K, Yılmaz S, Cınar M, Akdogan A, Erdem H, Ozturk MA, Pay S, Dinc A. The factors considered as trigger for the attacks in patients with familial Mediterranean fever. Rheumatol Int 2013; 33:893-7.
  6. Kastner DL, Aksentijevich I, Goldbach-Mansky R. Autoinflammatory disease reloaded: a clinical perspective. Cell 2010; 140:784-90.
  7. Keser MG, Unusan N. The Effects of Diet and Microbiota on Attacks in Familial Mediterranean Fever Akd Med J 2023; 9(2):206 – 12.
  8. Kisla Ekinci RM, Balci S, Bisgin A, Cetin FT, Tumgor G. The contribution of diet preference to the disease course in children with familial Mediterranean fever: a cross-sectional study. Reumatologia 2020; 58 (2):81–6.
  9. Mansueto P, Seidita A, Chiavetta M, Genovese,D, Giuliano A, Priano W, Carroccio A, Casuccio A, Amodio E. Familial Mediterranean Fever and Diet: A Narrative Review of the Scientific Literature. Nutrients 2022; 14:3216.
  10. Yenokyan G, Armenian HK. Triggers for Attacks in Familial Mediterranean Fever: Application of the Case-Crossover Design. Am J Epidemiol 2012; 175(10):1054–61.
  11. González Cernadas L, Rodríguez-Romero B, Carballo-Costa L. Importance of nutritional treatment in the inflammatory process of rheumatoid arthritis patients; a review. Nutr Hosp 2014; 29(2):237-45.
  12. Wu H, Huang X, Qiu H, Zhao M, Liao W, Yuan S, Xie Y, Dai Y, Chang C, Yoshimura A, Lu Q. High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells. Sci Rep 2016; 6:28065.
  13. Lee S, Rodman J, Hsu V, Wise L. Beliefs, Experiences, and Openness Regarding Dietary Interventions: Data from an Urban Hispanic Population with Rheumatic Disease in the US. Arthritis Care & Research 2023; 75(10):2207-14.
  14. Sköldstam L, Hagfors L, Johansson G. An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis. Ann Rheum Dis 2003; 62(3):208-14.
  15. Cerhan JR, Saag KG, Merlino LA, Mikuls TR, Criswell LA. Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women. Am J Epidemiol 2003; 157(4):345–54.
  16. Shapiro JA, Koepsell TD, Voigt LF, Dugowson CE, Kestin M, Nelson JL. Diet and rheumatoid arthritis in women: a possible protective effect of fish consumption. Epidemiology 1996: 256–63.
  17. Cebicci H, Aykac Cebicci M, Sahan M, Gurbuz S, Karaca B, Karakus A, Tomruk Sutbeyaz S, Sunkak S. Triggers for attacks in familial mediterranean fever: Are there any regional or ethnic differences? Acta Med Mediterr 2014; 30:1349.