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Journals / Türkiye Diyabet ve Obezite Dergisi / 2026 / Cilt: 10 Sayı: 2

Histopathological Scoring Systems in the Assessment of Renal Damage in Experimental Diabetic Nephropathy

Deneysel Diyabetik Nefropatide Böbrek Hasarının Değerlendirilmesinde Histopatolojik Skorlama Sistemleri

Yonca Durmuş(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ)0000-0002-2378-6494
Meryem Akpolat Ferah(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ)0000-0002-3419-1728
Mete Keçeci(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ)0000-0002-2144-4730
Pages
226–234
Publication Date
2026-08-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of this article is to provide a comprehensive guide to the different parameters and scoring systems used to assess kidney tissue damage observed in experimental DN animal models.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes and a leading cause of end-stage renal failure.
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Key Findings & Data:Currently, DN affects a significant number of people with diabetes worldwide and accounts for approximately one-third of patients with chronic kidney disease.
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Conclusion & Impact:The aim of this article is to provide a comprehensive guide to the different parameters and scoring systems used to assess kidney tissue damage observed in experimental DN animal models.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Diyabetik nefropati · Histopatoloji · Böbrek

Abstract

Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes and a leading cause of end-stage renal failure. Currently, DN affects a significant number of people with diabetes worldwide and accounts for approximately one-third of patients with chronic kidney disease. Therefore, early diagnosis of DN is crucial for preventing or slowing its progression through appropriate treatment. Histopathological evaluation of DN is extremely important for determining the stages of the disease and applying the correct treatment approach. Early stages of DN are characterized by thickening of the glomerular and tubular basement membranes, accumulation of extracellular matrix elements in the glomerular mesangium, and structural changes related to hypertrophy in the glomerular and tubular epithelia. Understanding DN requires statistical analysis by scoring the observed pathological changes and converting them into semi-quantitative or quantitative data. However, the existence of different animal species and different experimental DN models leads to confusion in these scoring methods. Therefore, histopathological scoring systems used for experimental DN models have been examined in detail in studies conducted in the PubMed database over the last decade. The aim of this article is to provide a comprehensive guide to the different parameters and scoring systems used to assess kidney tissue damage observed in experimental DN animal models.

Özet

Diyabetik nefropati (DN) diyabetin en sık görülen mikrovasküler komplikasyonlarından biridir ve son dönem böbrek yetmezliğine yol açan nedenlerin başında gelmektedir. Günümüzde DN, dünya çapında diyabetli önemli sayıda kişiyi etkilemektedir ve kronik böbrek hastalığı olan hastaların yaklaşık üçte birini oluşturmaktadır. Bu nedenle DN gelişiminin mümkün olan en erken dönemde tanınması, gerekli tedavilerle hastalığın önlenmesi ya da gelişiminin yavaşlatılması son derece önemlidir. DN’nin histopatolojik değerlendirilmesi, hastalığın evrelerini belirleyerek doğru tedavi yaklaşımının uygulanabilmesi açısından son derece önemlidir. DN’nin erken dönemde glomerül ve tübül bazal membranlarının kalınlaşması, glomerül mezangiumunda ekstrasellüler matriks elemanlarının birikmesi, glomerül ve tübül epitellerinde hipertrofi ile ilgili yapısal değişimleri içerdiği açıklanmıştır. DN’nin anlaşılabilmesi için, gözlenen patolojik değişikliklerin puanlanarak semikantitatif veya kantitatif verilere dönüştürülerek istatiksel analiz yapılması oldukça önemlidir. Fakat farklı hayvan türlerinin ve farklı deneysel DN modellerinin varlığı, bu skorlama yöntemlerinde karışıklığa neden olmaktadır. Bu nedenle, DN deneysel modelleri için kullanılan histopatolojik skorlama sistemleri, son on yılda PubMed veritabanında yürütülen çalışmalarda ayrıntılı olarak incelenmiştir. Bu makalenin amacı, deneysel DN hayvan modellerinde gözlenen böbrek doku hasarını değerlendirmek için kullanılan farklı parametreler ve skorlama sistemlerine ilişkin kapsamlı bir kılavuz sunmaktır.

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Cite This Article

Durmuş, Y., Ferah, M. A., Keçeci, M. (2026). Histopathological Scoring Systems in the Assessment of Renal Damage in Experimental Diabetic Nephropathy. Türkiye Diyabet ve Obezite Dergisi, Cilt: 10 Sayı: 2, 226–234. https://ajindex.com/articles/1436192

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