Journals / Türk Biyokimya Dergisi / 2018 / Cilt: 43 - Sayı: 1

Özlem Akça, Mehmet Yiğit Özgün, Özgür Akbayır and Mustafa Uygar Kalaycı Evaluation of laboratory parameters in the diagnosis of acute appendicitis

Akut apandisit teşhisinde laboratuvar parametrelerinin değerlendirilmesi

Pages
64–70
Publication Date
2022-11-05
DOI
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WBC, neutrophil count, NLRwere significantly higher in Group 2 (p < 0.001 for each),whereas fibrinogen levels, lymphocyte count and the PLTcounts were significantly higher in Group 1 (p = 0.03, 0.002and 0.003, respectively).Discussion and conclusion: WBC, neutrophil and NLRare predictive for the diagnosis of AA, whereas elevatedlevels of fibrinogen, high lymphocyte and PLT count arepredictivefor non-appendicial pathology with low diagnosticaccuracies.

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Objective & Hypothesis:Introduction: The aim of this prospective study was toinvestigate the diagnostic value of the fibrinogen level,platelet (PLT) count, mean platelet volume (MPV), lymphocytecount, neutrophil/lymphocyte ratio (NLR) andC-reactive protein (CRP) level with white blood cell (WBC)and neutrophil count in acute appendicitis (AA).Methods: One hundred and ninety-seven patients whowere admitted with the findings of acute abdomen andoperated on with a preoperative diagnosis of AA wereincluded in this prospective observational study.
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Key Findings & Data:Aftersurgery, according to the histopathological results of theappendix, patients were classified as Group 1; with normalhistology of appendix vermicularis, Group 2; patients withpositive histology for appendicitis with or without perforation,periappendiceal abscess, suppurative, gangrenousor ulcerophlegmonous appendicitis.Results: In the comparison of the two groups, the differencebetween CRP and MPV were insignificant (p = 0.12and p = 0.09, respectively).
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Conclusion & Impact:WBC, neutrophil count, NLRwere significantly higher in Group 2 (p < 0.001 for each),whereas fibrinogen levels, lymphocyte count and the PLTcounts were significantly higher in Group 1 (p = 0.03, 0.002and 0.003, respectively).Discussion and conclusion: WBC, neutrophil and NLRare predictive for the diagnosis of AA, whereas elevatedlevels of fibrinogen, high lymphocyte and PLT count arepredictivefor non-appendicial pathology with low diagnosticaccuracies.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: The aim of this prospective study was toinvestigate the diagnostic value of the fibrinogen level,platelet (PLT) count, mean platelet volume (MPV), lymphocytecount, neutrophil/lymphocyte ratio (NLR) andC-reactive protein (CRP) level with white blood cell (WBC)and neutrophil count in acute appendicitis (AA).Methods: One hundred and ninety-seven patients whowere admitted with the findings of acute abdomen andoperated on with a preoperative diagnosis of AA wereincluded in this prospective observational study. Aftersurgery, according to the histopathological results of theappendix, patients were classified as Group 1; with normalhistology of appendix vermicularis, Group 2; patients withpositive histology for appendicitis with or without perforation,periappendiceal abscess, suppurative, gangrenousor ulcerophlegmonous appendicitis.Results: In the comparison of the two groups, the differencebetween CRP and MPV were insignificant (p = 0.12and p = 0.09, respectively). WBC, neutrophil count, NLRwere significantly higher in Group 2 (p < 0.001 for each),whereas fibrinogen levels, lymphocyte count and the PLTcounts were significantly higher in Group 1 (p = 0.03, 0.002and 0.003, respectively).Discussion and conclusion: WBC, neutrophil and NLRare predictive for the diagnosis of AA, whereas elevatedlevels of fibrinogen, high lymphocyte and PLT count arepredictivefor non-appendicial pathology with low diagnosticaccuracies.

Özet

Giriş ve Amaç: Bu prospektif çalışmanın amacı akut apandisit teşhisinde kan lökosit sayımı ve nötrofil oranı yanında kan fibrinojen düzeyi, trombosit sayımı, ortalama trombosit volume (MPV), lenfosit sayısı, nötrofil/ lenfosit oranı (NLR) ve C-Reaktif Protein (CRP) düzeylerinin tanısal değerini araştırmaktır. Yöntem ve Gereçler: Bu prospektif gözlemsel çalışmaya akut karın ile başvurmuş ve akut apandisit teşhisi konularak ameliyat edilen yüz doksan yedi hasta dahil edildi. Histopatolojik sonuçlarına göre, hastalar iki gruba ayrılmıştır: Grup 1, apendiks vermicularis histopatolojisi normal olan hastalar; Grup 2 apendiks vermiformis patolojisi; perforasyon, periappendiküler apse, süpüratif gangren veya flegmon olup olmadığına bakılmaksızın akut apandisit olan hastalar idi. Bulgular: Grup 1’de 28 (% 14.2) hasta ve Grup 2′de 169 (% 85.8) hasta saptandı. İki grubun karşılaştırılmasında, CRP ve MPV değerleri arasındaki fark (sırasıyla p = 0.12 ve p = 0.09) istatiksel olarak anlamlı bulunmadı. Lökosit değerleri, nötrofil sayımı ve nötrofil/lenfosit oranı Grup 2’de anlamlı olarak yüksek bulundu (her biri için p < 0.001). Fibrinojen düzeyi, lenfosit ve trombosit sayımı Grup 1’de anlamlı olarak yüksek bulundu (p = 0.03, 0.002, 0.003 sırasıyla). Tartişma ve Sonuç: Lökosit sayısı, nötrofil sayımı ve nötrofil/ lenfosit oranı akut apandisitte yüksek tanısal özellikte iken yüksek fibrinojen düzeyi, yüksek lenfosit ve trombosit sayısı, düşük tanısal doğruluk ile akut apandisit patolojisi olmayan grupta kullanılabilir.

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Cite This Article

ULUKENT, S. C., AKBAYIR, Ö., SARICI, İ. Ş., KALAYCI, M. U., ÖZYÜREK, E. Ş., AKÇA, Ö., ŞAHBAZ, N. A., ÖZGÜN, M. Y. (2022). Özlem Akça, Mehmet Yiğit Özgün, Özgür Akbayır and Mustafa Uygar Kalaycı Evaluation of laboratory parameters in the diagnosis of acute appendicitis. Türk Biyokimya Dergisi, Cilt: 43 - Sayı: 1, 64–70. https://ajindex.com/articles/620945

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