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Journals / Türk Biyokimya Dergisi / 2020 / Cilt: 45 - Sayı: 5

Immunoassay biomarkers of first and secondtrimesters: a comparison between pregnant Syrianrefugees and Turkish women

Birinci ve ikinci trimester immünoassay biyobelirteçleri: gebe Suriyeli mülteciler ve Türk kadınları arasında bir karşılaştırma

Nahide EKİCİ GÜNAY
Hüseyin AKSOY
Pages
499–505
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The ethnic diversity showed the greatest effect on fß-hCG.Conclusion: Race/ethnicity-specific regression coefficients and median values based on validated risk estimations should have to be used for fetal aneuploidy risk reports.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: It was aimed to investigate maternal serum hormone values used for aneuploidy screening, demographic characteristics and fetal measurements in the population of pregnant Syrian refugees (PSRs) and to compare with data from pregnant Turkish women (PTW).Material and methods: The study assessed data from 2697 pregnant who underwent triple and double screening tests, including 1738 Turkish and 959 Syrian women.
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Key Findings & Data:By multivariate linear regression analysis, group-specific regression coefficients were estimated.Results: Mean total age and weight were found to be significantly different and lower in PSRs in all gestational ages evaluated (p < 0.001; p < 0.001).
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Conclusion & Impact:The ethnic diversity showed the greatest effect on fß-hCG.Conclusion: Race/ethnicity-specific regression coefficients and median values based on validated risk estimations should have to be used for fetal aneuploidy risk reports.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: It was aimed to investigate maternal serum hormone values used for aneuploidy screening, demographic characteristics and fetal measurements in the population of pregnant Syrian refugees (PSRs) and to compare with data from pregnant Turkish women (PTW).Material and methods: The study assessed data from 2697 pregnant who underwent triple and double screening tests, including 1738 Turkish and 959 Syrian women. The maternal serum biomarkers, demographic characteristics and fetal sonography measurements were compared and biases were calculated. By multivariate linear regression analysis, group-specific regression coefficients were estimated.Results: Mean total age and weight were found to be significantly different and lower in PSRs in all gestational ages evaluated (p < 0.001; p < 0.001). The first trimester, median biases for fß-hCG were found to be higher by 38% and 24.5% for weeks 11 and 13, respectively. In the second trimester, median values of tß-hCG showed negative biases of 11.8% and 21.2% on weeks 16 and 19 in PSRs, respectively (p < 0.001). It was considered that ethnicity has a stronger effect on first trimester hormone biomarkers than second trimester. The ethnic diversity showed the greatest effect on fß-hCG.Conclusion: Race/ethnicity-specific regression coefficients and median values based on validated risk estimations should have to be used for fetal aneuploidy risk reports.

Özet

Amaç: Gebe Suriyeli sığınmacıların (GSS) anöploidi tara ması sırasında kullanılan demografik özellikleri, fetalölçümleri ve maternal serum hormon değerlerini incele nerek gebe Türk kadınlarının (GTK) verileriyle karşılaştı rılması amaçlandı. Gereç ve Yöntem: Çalışmada 1738 Türk ve 959 Suriyelikadın olmak üzere üçlü ve çift tarama testi uygulanan2697 gebenin verileri değerlendirildi. Maternal serumbiyobelirteçleri, demografik özellikleri ve fetal sonografiölçümleri karşılaştırıldı ve yanlılıklar hesaplandı. Çokdeğişkenli doğrusal regresyon analizi ile gruba özgü reg resyon katsayıları hesaplandı. Bulgular: Değerlendirilen tüm gebelik yaşlarındaGSS’larda ortalama toplam yaş ve ağırlık anlamlı olarakfarklı ve düşük bulundu (p < 0.001; p < 0.001). Birincitrimester, fß-hCG için ortanca yanlılıkları 11. ve 13. haf talarda sırasıyla % 38 ve % 24.5 daha yüksek olduğubulundu. İkinci trimesterde, tß-hCG’nin ortanca değer leri GSS’lerde 16 ve 19. haftalarda sırasıyla % 11.8 ve %21.2 negatif yanlılık gösterdi (p < 0.001). Etnik kökeninilk trimester hormon biyobelirteçleri üzerinde ikinci tri mesterden daha güçlü bir etkiye sahip olduğu düşünül müştür. Etnik çeşitlilik en büyük etkiyi fß-hCG hormoneüzerinde göstermiştir. Sonuç: Fetal anöploidi risk raporlarında ırk/etnisiteyeözgü regresyon katsayıları ve valide edilmiş risk tahmin lerine dayanan ortanca değerlerin kullanılması gereklidir.

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Cite This Article

GÜNAY, N. E., AKSOY, H. (2022). Immunoassay biomarkers of first and secondtrimesters: a comparison between pregnant Syrianrefugees and Turkish women. Türk Biyokimya Dergisi, Cilt: 45 - Sayı: 5, 499–505. https://ajindex.com/articles/621201

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