Journals / Türk Biyokimya Dergisi / 2020 / Cilt: 45 - Sayı: 1

Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia

Bakteriyeminin erken teşhisinde Nötrofil/Lenfosit Oranı, Trombosit/Lenfosit Oranı ve Prokalsitonin tanısal değerleri

Pages
57–64
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, among the markers tested, PCT has the best diagnostic performance for Gram-negative bacteremia.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study is to investigate the diag-nostic accuracy of complete blood count (CBC), C-reactive protein (CRP), and procalcitonin (PCT) levels, which can be used as a cultural alternative for the diagnosis of infec-tion faster.Methods: The patients were divided into two groups as bacteremia (n = 220) and nonbacteremia group (n = 812).
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Key Findings & Data:The bacteremia group was divided into two subgroups as Gram-positive bacteria (n = 167) and Gram-negative bacte-ria (n = 53).Results: PCT, CRP, red blood cell distribution width (RDW), platelet distribution width (PDW), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV) levels were significantly higher in patients with positive blood culture than non-patients.
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Conclusion & Impact:However, among the markers tested, PCT has the best diagnostic performance for Gram-negative bacteremia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study is to investigate the diag-nostic accuracy of complete blood count (CBC), C-reactive protein (CRP), and procalcitonin (PCT) levels, which can be used as a cultural alternative for the diagnosis of infec-tion faster.Methods: The patients were divided into two groups as bacteremia (n = 220) and nonbacteremia group (n = 812). The bacteremia group was divided into two subgroups as Gram-positive bacteria (n = 167) and Gram-negative bacte-ria (n = 53).Results: PCT, CRP, red blood cell distribution width (RDW), platelet distribution width (PDW), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV) levels were significantly higher in patients with positive blood culture than non-patients. The serum PCT levels were 3.80 (0.83–37.68) and 0.43 (0.16–2.61) ng/mL, respec-tively (p < 0.001) in the patients with Gram-negative and Gram-positive bacterium. PCT at a cut-off value of 0.45 ng/mL for Gram-negative bacterium; sensitivity of 90% and specificity of 64%.Conclusions: It is important that RDW, PDW, NLR, PLR, MPV values can be measured quickly, easily and cheaply by automatic hematological analysis. However, among the markers tested, PCT has the best diagnostic performance for Gram-negative bacteremia.

Özet

Amaç: Bu çalışmanın amacı, enfeksiyonun daha hızlıtanısında kültüre alternatif olarak kullanılabilecek tamkan sayımı, C reaktif protein (CRP) ve prokalsitonin (PCT)düzeylerinin tanısal doğruluğunu araştırmaktır. Yöntem: Hastalar bakteriyemi (n = 220) ve bakteriyemiolmayan grup (n = 812) olarak iki gruba ayrıldı. Bakteri- yemi grubu Gram pozitif bakteri (n = 167) ve Gram negatifbakteri (n = 53) olmak üzere iki alt gruba ayrıldı. Bulgular: Kan kültürü pozitif olan hastalarda olmayanlaragöre PCT, CRP, eritrosit dağılım genişliği (RDW), trombo- sit dağılım genişliği (PDW), nötrofil lenfosit oranı (NLR),trombosit lenfosit oranı (PLR) ve ortalama trombosithacmi (MPV) düzeyleri anlamlı olarak yüksek bulundu.Gram -negatif ve Gram- pozitif bakteriyemili hastalardaserum PCT düzeyleri sırasıyla 3.80 (0.83–37.68) ve 0.43(0.16–2.61) ng/mL idi (p < 0.001). Gram negatif bakteri içinPCT 0.45 ng/mL’lik bir kesme değerinde; % 90 duyarlılıkve% 64 özgüllüğe sahipdi. Sonuç: RDW, PDW, NLR, PLR, MPV değerlerinin otoma- tik hematolojik analizlerle hızlı, kolay ve ucuz bir şekildeölçülebilmesi önemlidir. Bununla birlikte, test edilenbelirteçler arasında PCT, gram negatif bakteremi için eniyi teşhis performansına sahiptir.

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Cite This Article

ÇOLAK, A., TOPRAK, B., YILMAZ, N., AKSİL, M. Z. (2022). Diagnostic values of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio and procalcitonin inearly diagnosis of bacteremia. Türk Biyokimya Dergisi, Cilt: 45 - Sayı: 1, 57–64. https://ajindex.com/articles/620745

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