Journals / Turkish Journal of Gastroenterology / 2021 / Cilt: 32 - Sayı: 3

Can Ischemia Modified Albumin (IMA) Levels Be a Predictor of Acute Pancreatitis?

Pages
327–335
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In our study, the association between IMA and AP has been evaluated in the context of prognostic scoring and disease severity

📌 3 Key Takeaways

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Objective & Hypothesis:Background: We aimed to evaluate the value of ischemia modified albumin (IMA) as a prognostic marker in acute pancreatitis (AP) patients, determine whether it is efficient in assessing the disease severity or not, and to estimate the correlation between IMA and the inflammatory markers, prognostic markers and scoring systems routinely used in clinical practice.
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Key Findings & Data:Methods: 100 adult patients (18 years and older) who have been hospitalized and evaluated with AP diagnosis in Tepecik Training and Research Hospital,, Department of Gastroenterology, between April 1, 2017 and April 1, 2018 have been enrolled in the study.
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Conclusion & Impact:In our study, the association between IMA and AP has been evaluated in the context of prognostic scoring and disease severity
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Özet

Background: We aimed to evaluate the value of ischemia modified albumin (IMA) as a prognostic marker in acute pancreatitis (AP) patients, determine whether it is efficient in assessing the disease severity or not, and to estimate the correlation between IMA and the inflammatory markers, prognostic markers and scoring systems routinely used in clinical practice. Methods: 100 adult patients (18 years and older) who have been hospitalized and evaluated with AP diagnosis in Tepecik Training and Research Hospital,, Department of Gastroenterology, between April 1, 2017 and April 1, 2018 have been enrolled in the study. Patients have been stratified disease etiology (biliary or non-biliary). The non-biliary group has been divided into subgroups as alcoholic, lipemic, or idiopathic. Disease severity has been categorized as mild, moderate, or severe pancreatitis according to the Atlanta classification. Ranson, Harmless Acute Pancreatitis Score (HAPS), Bedside Severity Index for Acute Pancreatitis (BISAP) scores have been determined for each patient. Patients have been grouped as necrotizing or edematous according to the Atlanta classification. Results: According to our findings, IMA has been found to be correlated with disease severity, Ranson and BISAP scores, and procalcitonin levels. We have observed that some laboratory parameters including blood urea nitrogen and hematocrit levels and HAPS scoring system are not correlated to IMA. Conclusion: Our study is the first study to compare multiple prognostic factors with IMA in AP patients. In our study, the association between IMA and AP has been evaluated in the context of prognostic scoring and disease severity

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Cite This Article

YARKICI, H., HAKİM, G. D., ARI, E. M., AKAR, H., ÇOLAK, A. (2021). Can Ischemia Modified Albumin (IMA) Levels Be a Predictor of Acute Pancreatitis?. Turkish Journal of Gastroenterology, Cilt: 32 - Sayı: 3, 327–335. https://ajindex.com/articles/408866

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References (3)

  1. Kumar V, Abbas AK, Fausto N, Mitchell RN. Robbins Basic Pathology. 8th ed. Philadelphia: Saunders Elsevier; 2007:675-685
  2. Stone HH, Fabian TC, Dunlop WE. Gallstone pancreatitis biliary tract pathology in relation to time of operation. Ann Surg. 1981;194(3):305-312. [CrossRef] 3. Cho JH, Kim TN, Chung HH, et al. Comparison of scoring systems in predicting the severity of acute pancreatitis. World J Gastroenterol. 2015;21(8):2387-2394. [CrossRef] 4. Winterbourn CC, Bonham MJD, Buss H, Abu-Zidan FM, Windsor JA. Elevated protein carbonyls as plasma markers of oxidative stres in acute pancreatitis. Pancreotology. 2003;3(5):375-382. [CrossRef] 5. Bar-Or D, Winkler JV, Vanbenthuysen K, Harris L, Lau E, Hetzel FW. Reduced albümin cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: a preliminary comparison to creatine kinase-MB, myoglobin, and troponin I. Am Heart J. 2001;141(6):985-991. [CrossRef] 6. Topaloglu N, Kucuk A, Tekin M, et al. Serum ischemia-modified albumin levels in experimental model of acute pancreatitis. J Coll Phys Surg Pak. 2015;25(6):395-398. [CrossRef] 7. Maheshwari R, Subramanian RM. Severe acute pancreatitis and necrotizing pancreatitis. Crit Care Clin. 2016;32(2):279-290. [CrossRef] 8. Gross JB, Comfort MW, Mathieson DR, Power MH. Elevated values for serum amylase and lipase following the administration of opiates: a preliminary report. Proc Staff Meet Mayo Clin. 1951;26(5):81-87
  3. Kylänpää-Bäck ML, Takala A, Kemppainen E, Puolakkainen P, Haapiainen R, Repo H. Procalcitonin strip test in the early detection of severe acute pancreatitis. Br J Surg. 2001;88(2):222-227. [CrossRef] 10. Larvin M. Assessment of severity and prognosis in acute pancreatitis. Eur J Gastroenterol Hepatol. 1997;9(2):122-130. [CrossRef] 11. Wu BU, Johannes RS, Sun X, Conwell DL, Banks PA. Early changes in blood urea nitrogen predict mortality in acute pancreatitis. Gastroenterology. 2009;137(1):129-135. [CrossRef] 12. Wu BU, Bakker OJ, Papachristou GI, et al. Blood urea nitrogen in the early assessment of acute pancreatitis: an international validation study. Arch Intern Med. 2011;171(7):669-676. [CrossRef] 13. Tenner S. Initial management of acute pancreatitis: critical issues during the first hours. Am J Gastroenterol. 2004;99(12):2489- 2494. [CrossRef] 14. Baillargeon JD, Orav J, Ramagopal V, Tenner SM, Banks PA. Hemoconcentration is an early riskfactor for necrotizing pancreatitis. Am J Gastroenter