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Journals / Türk Anestezi ve Reanimasyon Dergisi / 2008 / Cilt: 36 - Sayı: 1

The impact of dexmedetomidine us midazolam on coagulation factors during nasal surgery

Nazal cerrahi olgularında deksmedetomidin ve midazolam kullanımının koagülasyon üzerine etkileri

Hasan KOÇOĞLU
Kazım KARAASLAN
Fahrettin YILMAZ
Erdinç SERİN
Nebahat GÜLCÜ
Cemil ÇOLAK
Pages
31–37
Publication Date
2022-11-05
DOI
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Results: Postoperative early (t1) and late (t2) Hb, Htc, aPTT and ATIII were decreased in both groups, and fibrinogen were decreased on these times in group M compared with preoperative values (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Dexmedetomidine is an a2 adrenergic receptor agonist and has sedative analgesic properties.
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Key Findings & Data:In Group D, dexmedetomidine was infused iv 1 µg kg-1 over 10 min followed by 0.5 µg kg-1 h-1.
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Conclusion & Impact:Results: Postoperative early (t1) and late (t2) Hb, Htc, aPTT and ATIII were decreased in both groups, and fibrinogen were decreased on these times in group M compared with preoperative values (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Dexmedetomidine is an a2 adrenergic receptor agonist and has sedative analgesic properties. We aimed to investigate the effects of dexmedetomidine coagulation system in monitored anesthesia care (MAC) patients, and to compare it with that of midazolam.Material and Methods: Sixty patients undergoing nasal surgery with local anesthesia were recruited. In Group D, dexmedetomidine was infused iv 1 µg kg-1 over 10 min followed by 0.5 µg kg-1 h-1. In Group M, midazolam was given iv 40 µg kg-1 followed by 50 µg kg-1 h-1. The effects of both drugs on coagulation system were evaluated by means of hemoglobin (Hb), hematocrit (Htc), platelet count, fibrinogen, protrombin time, active partial tromboplastine time (aPTT), INR, protein C, protein S and antitrombin III (ATIII) parameters with preoperatively (t0), early (t1) and 6 hours after postoperatively (t2). Results: Postoperative early (t1) and late (t2) Hb, Htc, aPTT and ATIII were decreased in both groups, and fibrinogen were decreased on these times in group M compared with preoperative values (p

Özet

Amaç: Deksmedetomidin sedatif ve analjezik özelliği olan bir a2 agonist ajandır. Bu çalışmada monitörize anestezik bakım (MAB) uygulanan olgularda deksmedetomidin ile midazolamın koagülasyon üzerine olan etkilerinin karşılaştırılması amaçlanmıştır.Gereç ve Yöntem: Lokal anestezi ile nazal cerrahi planlanan on sekiz-elli yaş arası, ASA I-II risk grubunda altmış olgu çalışmaya alındı. Deksmedetomidin grubunda (Grup D) 1 µg kg-1 deksmedetomidin iv yükleme dozunu takiben 0,5 µg kg-1 st-1 dozu ile devam edildi. Midazolam grubunda (Grup M) ise iv 40 µg kg-1 yükleme dozunun ardından 50 µg kg-1 st-1 dozunda midazolam infüzyonuna operasyon sonuna kadar devam edildi. Her iki grupta, operasyon öncesi (t0), operasyondan hemen sonra (t1) ve operasyon bitiminden 6 saat sonra (t2) olgulardan alınan kan örneklerinde hemoglobin (Hgb), hematokrit (Htc), trombosit (Trmb), protrombin zamanı (PZ), aktive parsiyel trombin zamanı (aPTZ), INR, protein C (PC), protein S (PS), fibrinojen ve antitrombin III (ATIII) değerleri ölçüldü. Grup içi ve gruplar arası karşılaştırma yapıldı. Bulgular: Her iki grupta preoperatif değerler ile karşılaştırıldığında, hem t1 hem de t2 ölçümlerinde Hgb, Htc, aPTZ ve ATIII değerlerinde anlamlı düzeyde azalma gözlendi (p

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Cite This Article

KOÇOĞLU, H., KARAASLAN, K., YILMAZ, F., SERİN, E., GÜLCÜ, N., ÇOLAK, C. (2022). The impact of dexmedetomidine us midazolam on coagulation factors during nasal surgery. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 36 - Sayı: 1, 31–37. https://ajindex.com/articles/620008

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