Journals / Kulak Burun Boğaz İhtisas Dergisi / 2011 / Cilt: 21 - Sayı: 5

Kronik rinosinüzit ve alerjik rinitte yüksek duyarlılıklı C-reaktif protein düzeyleri

High sensitivity C-reactive protein levels in chronic rhinosinusitis and allergic rhinitis

Pages
266–269
DOI
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Conclusion: Allergic rhinitis, CRS with nasal polyps and CRS without nasal polyp groups compared with the control group were statistically not significant differences in the hs-CRP levels with peripheral blood.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: In this study we evaluated the relationship between peripheral blood high sensitivity C-reactive protein (hs-CRP) levels with allergic rhinitis and chronic rhinosinusitis (CRS) with or without nasal polyps.
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Key Findings & Data:Patients and Methods: The study included 100 patients who were divided into four groups each 25 patients; as follows: allergic rhinitis (group 1), CRS with nasal polyps (group 2), CRS without nasal polyps (group 3), and controls (group 4) who were non-smokers.
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Conclusion & Impact:Conclusion: Allergic rhinitis, CRS with nasal polyps and CRS without nasal polyp groups compared with the control group were statistically not significant differences in the hs-CRP levels with peripheral blood.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: In this study we evaluated the relationship between peripheral blood high sensitivity C-reactive protein (hs-CRP) levels with allergic rhinitis and chronic rhinosinusitis (CRS) with or without nasal polyps. Patients and Methods: The study included 100 patients who were divided into four groups each 25 patients; as follows: allergic rhinitis (group 1), CRS with nasal polyps (group 2), CRS without nasal polyps (group 3), and controls (group 4) who were non-smokers. All patients underwent a detailed symptom enquiry, physical examination, and investigations including a complete blood count and radiograph of the paranasal sinuses. The hs-CRP was measured in all the patients by a semi quantitative assay using the latex enhanced immunonephelometric test. Results: There was no statistically significant difference in the levels of hs-CRP between the group 1, group 2, and group 3 by the control group respectively (p=0.861, p=0.7196, and p=0.127). Conclusion: Allergic rhinitis, CRS with nasal polyps and CRS without nasal polyp groups compared with the control group were statistically not significant differences in the hs-CRP levels with peripheral blood.

Özet

Amaç: Bu çalışmada alerjik rinitli, nazal polipli ve polipsiz kronik rinosinüzitli (KRS) hastaların periferik kanlarındaki yüksek duyarlılıklı C-reaktif protein (hs-CRP) düzeyleri arasındaki ilişki değerlendirildi. Hastalar ve Yöntemler: Çalışmaya dahil edilen 100 hasta; alerjik rinitli hastalar (grup 1), nazal polipli KRS’li hastalar (grup 2), nazal polipsiz KRS’li hastalar (grup 3) ve sigara içmeyen kontroller (grup 4) olmak üzere 25’er kişilik dört gruba ayrıldı. Tüm hastalara detaylı semptom sorgulaması, fizik muayene, tam kan sayımı ve paranazal sinüs radyografileri yapıldı. Tüm hastalarda hs-CRP düzeyleri semi kantitatif olarak, lateks ile güçlendirilmiş immünonefelometrik yöntem ile ölçüldü. Bulgular: Yüksek duyarlılıklı-CRP düzeyleri açısından grup 1, grup 2 ve grup 3 ile kontrol grubu arasında istatistiksel olarak anlamlı farklılık yoktu (sırasıyla; p=0.861, p=0.7196 ve p=0.127). Sonuç: Alerjik rinit, nazal polipli KRS ve nazal polipsiz KRS gruplarında periferik kan hs-CRP düzeyleri kontrol grubu ile karşılaştırıldığında istatistiksel anlamlı farklılık saptanmadı.

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Cite This Article

YILDIRIM, Y. S., APUHAN, T., KOÇOĞLU, M. E., ŞİMŞEK, T., KAZAZ, H. (2011). Kronik rinosinüzit ve alerjik rinitte yüksek duyarlılıklı C-reaktif protein düzeyleri. Kulak Burun Boğaz İhtisas Dergisi, Cilt: 21 - Sayı: 5, 266–269. https://ajindex.com/articles/343085

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References (14)

  1. Nakayama T, Sonoda S, Urano T, Yamada T, Okada M. Monitoring both serum amyloid protein A and C-reactive protein as inflammatory markers in infectious diseases. Clin Chem 1993;39:293-7
  2. Tillett WS, Francis T. Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exp Med 1930;52:561-71
  3. Chang CC, Sun CF, Pai HJ, Wang WK, Hsieh CC, Kuo LM, et al. Preoperative serum C-reactive protein and gastric cancer; clinical-pathological correlation and prognostic significance. Chang Gung Med J 2010;33:301-12
  4. Castell JV, Gömez-Lechön MI, David M, Fabra R, Trullenque R, Heinrich PC. Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology 1990;12:1179-86
  5. Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest 2003;111:1805-12
  6. Sahoo RC, Acharya PR, Noushad TH, Anand R, Acharya VK, Sahu KR. A study of high-sensitivity C-reactive protein in bronchial asthma. Indian J Chest Dis Allied Sci 2009;51:213-6
  7. Allam MH, Said AF, El Samie Omran AA, Abd El-Reheim DM, Kasem AH. High sensitivity C-reactive protein: its correlation with sputum cell counts in bronchial asthma. Respir Med 2009;103:1878-84
  8. Olafsdottir IS, Gislason T, Thjodleifsson B, Olafsson I, Gislason D, Jögi R, et al. C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study. Thorax 2005;60:451-4
  9. Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M, et al. High sensitivity C-reactive protein in asthma. Eur Respir J 2006;27:908-12
  10. Meitzer EO, Hamilos DL, Hadley IA, Lanza DC, Marple BF, Nicklas RA, et al. Rhinosinusitis: Establishing definitions for clinical research and patient care. Otolaryngol Head Neck Surg 2004;131:Sl-62
  11. Rifai N, Tracy RP, Ridker PM. Clinical efficacy of an automated high-sensitivity C-reactive protein assay. Clin Chem 1999;45:2136-41
  12. Zietkowski Z, Skiepko R, Tomasiak-Lozowska MM, Mroczko B, Szmitkowski M, Bodzenta-Lukaszyk A. Changes in high-sensitivity C-reactive protein in serum and exhaled breath condensate after intensive exercise in patients with allergic asthma. Int Arch Allergy Immunol 2010;153:75-85
  13. Tracy RP. Inflammation in cardiovascular disease: cart, horse, or both? Circulation 1998;97:2000-2
  14. Heikkilä K, Ebrahim S, Lawlor DA. A systematic review of the association between circulating concentrations of C reactive protein and cancer. J Epidemiol C