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Journals / Türk Anestezi ve Reanimasyon Dergisi / 2009 / Cilt: 37 - Sayı: 5

Assessment of the effects of hypertonic saline and hydroxyethyl starch on hemodynamic parametres and coagulation for hypervolemic hemodilution

Hipervolemik hemodilüsyonda, hipertonik (% 3’lük) nacl solüsyonu ve % 6’lık hidroksi etil nişasta 1300,4’ün hemodinami ve koagülasyon etkilerinin değerlendirilmesi

Fatma SARICAOĞLU
Yalçın EREM
Ülkü AYPAR
Meral KANBAK
Seda Banu AKINCI
Didem DAL
Bülent ATİLLA
Osman ÖZCEBE
Pages
287–296
Publication Date
2022-11-06
DOI
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Hemoglobin concentrations and platelet counts decreased with time, mean blood pressures and heart rates remained stable before and after fluid loading (p

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Objective & Hypothesis:Aim: The aim of this study was to compare intraoperative effects of hypertonic saline (HS, 3 % NaCl) in hypervolemic hemodilution versus 6 % hydroxyethyl starch (HES, mean molecular weight 130kDA/0.4) on hemodynamic and coagulation parameters in patients scheduled for total hip replacement surgery.Materials and Methods: Twenty patients scheduled to undergo total hip replacement with standard spino-epidural anesthesia were randomly allocated into two groups.
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Key Findings & Data:Study solutions consisting of either HS % 3 or HES 6 % solutions in coded bags were delivered at a dose of 250 mL/m2 in 20 minutes.
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Conclusion & Impact:Hemoglobin concentrations and platelet counts decreased with time, mean blood pressures and heart rates remained stable before and after fluid loading (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of this study was to compare intraoperative effects of hypertonic saline (HS, 3 % NaCl) in hypervolemic hemodilution versus 6 % hydroxyethyl starch (HES, mean molecular weight 130kDA/0.4) on hemodynamic and coagulation parameters in patients scheduled for total hip replacement surgery.Materials and Methods: Twenty patients scheduled to undergo total hip replacement with standard spino-epidural anesthesia were randomly allocated into two groups. Study solutions consisting of either HS % 3 or HES 6 % solutions in coded bags were delivered at a dose of 250 mL/m2 in 20 minutes. Vital signs and, laboratory parameters such as complete blood count, prothrombin time, activated partial thromboplastin time and fibrinogen, coagulation factors (II, V, VII, VIII, X) were assessed before and after study fluid loading, after completion of the surgery and 24 hours after the surgery.Results: The mean (±SD) amount of the study fluids infused were 382±135 mL HS and 459±67 mL HES. Hemoglobin concentrations and platelet counts decreased with time, mean blood pressures and heart rates remained stable before and after fluid loading (p

Özet

Amaç: Total kalça protezi yapılacak olgularda, intraoperatif hipervolemik hemodilüsyonda, hipertonik salin (HS, % 3 NaCl) solüsyonu ile % 6’lık Hidroksi Etil Nişasta (HES, ortalama molekül ağırlığı 130kDA/0,4) solüsyonunun hemodinami ve koagülasyon testleri üzerine etkilerini karşılaştırmaktır. Gereç ve Yöntem: Standart spino-epidural anestezi ile total kalça protezi yapılacak 20 hasta rasgele iki gruba ayrıldı. % 3’lük HS veya % 6’lık HES içeren kodlanmış torbalardaki çalışma sıvısı, 20 dk.’da 250 mL m2-1 verildi. Çalışma sıvısı verilmesi öncesinde ve sonrasında, cerrahi bitiminde ve cerrahiden 24 saat sonra; vital bulgular, tam kan sayımı, protrombin zamanı, aktive parsiyel tromboplastin zamanı, fibrinojen ve koagülasyon faktörleri ölçüldü.Bulgular: Çalışma sıvısı olarak ortalama±SD 382±135 mL HS ve 459±67 mL HES verildi. Zamanla hemoglobin konsantrasyonu ve trombosit sayısında azalma saptandı (p

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Cite This Article

SARICAOĞLU, F., EREM, Y., AYPAR, Ü., KANBAK, M., AKINCI, S. B., DAL, D., ATİLLA, B., ÖZCEBE, O. (2022). Assessment of the effects of hypertonic saline and hydroxyethyl starch on hemodynamic parametres and coagulation for hypervolemic hemodilution. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 37 - Sayı: 5, 287–296. https://ajindex.com/articles/654684

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