Journals / KONURALP TIP DERGİSİ / 2022 / Cilt: 14 - Sayı: 2

The Evaluation of Relationship Between Monocyte/High-Density Lipoprotein Ratio (MHR) and COVID-19

Monosit/ Yüksek Dansiteli Lipoprotein (MHR) ve COVID-19 Arasındaki İlişkinin Değerlendirilmesi

Pages
386–390
Publication Date
2022-06-29
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Statistical significance level was accepted as p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Early diagnosis is important for severe diseases in COVID-19.
📊
Key Findings & Data:We aimed to investigate the relationship between MHR and diseases severity in COVID-19.
💡
Conclusion & Impact:Statistical significance level was accepted as p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:COVID-19 · Yüksek dansiteli lipoprotein · İnflamasyon

Abstract

Objective: Early diagnosis is important for severe diseases in COVID-19. Monocyte/high dansity lipoprotein ratio (MHR) is a new prognostic marker indicating inflammation. We aimed to investigate the relationship between MHR and diseases severity in COVID-19. Materials and Methods: Patients with laboratory confirmed COVID-19, were retrospectively analyzed. Clinical symptoms, signs and laboratory data on the first day of hospitalization were obtained from medical records of hospital. The clinical data of 301 patients were included in study. Cases were diagnosed on the basis of interim guidance of World Health Organization (WHO). Patients were classified into two groups as non-severe COVID-19 and severe COVID-19. MHR were calculated with laboratory data on the first day of hospitalization. The relationship between MHR level and COVID-19 severity was evaluated. Statistical analysis of the data was performed by using SPSS 25 (SPSS Inc., Chicago, IL, USA) package program. Statistical significance level was accepted as p

Özet

Amaç: COVID-19’da şiddetli hastalığı erken tanımak önemlidir. Monosit / yüksek dansiteli lipoprotein oranı (MHR), inflamasyon seyrini belirlemede kullanılan yeni bir belirteçtir. Bu çalışmada MHR ile COVID-19 seyri arasındaki ilişkiyi incelemek amaçlanmıştır. Materyal ve Metod: Laboratuvar ile konfirme edilmiş COVID-19 hastaları retrospektif olarak analiz edildi. Hastanemize başvuran hastanın ilk günki klinik semptomları, bulguları, ve laboratuvar sonuçları hastane bilgi işlem sisteminden taranarak kayıt altına alındı. Çalışmamıza toplam 301 hasta dahil edildi. Hastalar Dünya Sağlık Örgütü (DSÖ) klavuzu dikkate alınarak sınıflandırıldı. MHR hastaların hastaneye kabul edildiği ilk gün bakılan laboratuvar verileri kullanılarak hesaplandı. MHR ile COVID-19 şiddeti arasındaki ilişki değerlendirildi. Hasta verileri SPSS 25 (SPSS Inc., Chicago, IL, USA) kullanılarak analiz edildi. İstatistiksel olarak P

🔖

Cite This Article

COŞKUN, B., AYHAN, M., SARICAOĞLU, E. M., GÜNER, R., AKINCI, E., BUZGAN, T., KAYAASLAN, B., AYPAK, A., TEKÇE, A. Y. T., HASANOĞLU, İ., KALEM, A. K., ESER, F., BİLİR, Y. A., ÖZDEMİR, B. (2022). The Evaluation of Relationship Between Monocyte/High-Density Lipoprotein Ratio (MHR) and COVID-19. KONURALP TIP DERGİSİ, Cilt: 14 - Sayı: 2, 386–390. https://ajindex.com/articles/686639

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The lancet. 2020;395(10224):565-74
  2. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet. 2020;395(10223):497-506
  3. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The lancet. 2020;395(10223):507-13
  4. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. Jama. 2020;323(11):1061-9
  5. Arabi YM, Murthy S, Webb S. COVID-19: a novel coronavirus and a novel challenge for critical care. Intensive care medicine. 2020:1-4
  6. Giamarellos-Bourboulis EJ, Netea MG, Rovina N, Akinosoglou K, Antoniadou A, Antonakos N, et al. Complex immune dysregulation in COVID-19 patients with severe respiratory failure. Cell Host & Microbe. 2020
  7. Funderburg NT, Mehta NN. Lipid abnormalities and inflammation in HIV inflection. Current HIV/AIDS Reports. 2016;13(4):218-25
  8. Dreux M, Thi VLD, Fresquet J, Guérin M, Julia Z, Verney G, et al. Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra-and extra-cellular domains. PLoS pathogens. 2009;5(2)
  9. Hu X, Chen D, Wu L, He G, Ye W. Low serum cholesterol level among patients with COVID-19 infection in Wenzhou, China. China (February 21, 2020). 2020
  10. Yılmaz M, Kayançiçek H. A new inflammatory marker: elevated monocyte to HDL cholesterol ratio associated with smoking. Journal of clinical medicine. 2018;7(4):76
  11. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. New England journal of medicine. 2020
  12. Canpolat U, Çetin EH, Cetin S, Aydin S, Akboga MK, Yayla C, et al. Association of monocyte-to-HDL cholesterol ratio with slow coronary flow is linked to systemic inflammation. Clinical and Applied Thrombosis/Hemostasis. 2016;22(5):476-82
  13. Organization WH. Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected: interim guidance, 13 March 2020. World Health Organization; 2020
  14. Wu Z, McGoogan JM. Characteristics of and important lessons