Journals / Türk Anestezi ve Reanimasyon Dergisi / 2008 / Cilt: 36 - Sayı: 5

The effect of peroperatively and postoperatively used parasetamol on postoperative morphine consumption in spinal surgery

Spinal cerrahide peroperatif ve postoperatif kullanılan intravenöz parasetamolün postoperatif morfin tüketimine etkisi

Pages
304–309
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Fractioned morphine amounts, total morphine consumption and sedation scores were found to be lowered in Group MP (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The aim of this study is to investigate the effects of iv paracetamol with iv morphine PCA on postoperative morphine consumption in lumbar disc surgery.
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Key Findings & Data:Materials and Methods: After obtaining the approval of the hospital ethics committee and patient’s consents, 67 adult patients, in ASA group’s I-III, were randomly divided into two groups.
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Conclusion & Impact:Fractioned morphine amounts, total morphine consumption and sedation scores were found to be lowered in Group MP (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of this study is to investigate the effects of iv paracetamol with iv morphine PCA on postoperative morphine consumption in lumbar disc surgery. Materials and Methods: After obtaining the approval of the hospital ethics committee and patient’s consents, 67 adult patients, in ASA group’s I-III, were randomly divided into two groups. Group M (n=37) received iv morphine Patient Control Analgesia (PCA) postoperatively (bolus dose 1 mg, lock out time 10 min, limited 50 mg 24 hrs-1). At the skin closure, iv paracetamol (1 g infused in 15 min, 8 g 48 hrs-1) was also administered with morphine PCA in Group MP. All the patients with Visual Analogue Scale (VAS) scores over 3 were administered iv morphine in fractioned doses at recovery room (0. minute). The systolic and diastolic arterial pressures, hearth rate, SpO2, breathing rate, PCA demand number, replied demand number and total morphine consumption, sedation scores, VAS scores, presence of nausea and vomiting, itching and patches were recorded at 0., 30., 60. min, 2., 4., 6., 12., 18., 24. and 48. hrs. Fractioned morphine amounts and antiemetic consumption were also recorded. Fractioned morphine amounts, total morphine consumption and sedation scores were found to be lowered in Group MP (p

Özet

Amaç: Bu çalışmada; lomber disk cerrahisinde i.v. morfin ile yapılan hasta kontrollü analjeziye eklenen iv parasetamolün, postoperatif morfin tüketimi üzerine etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Hastane etik komitesi izni ve hasta onamları alındıktan sonra ASA I-III grubundan 67 erişkin olgu randomize olarak iki gruba ayrıldı. Grup M’ye (n=37) postoperatif olarak iv hasta kontrollü analjezi (HKA) ile morfin (bolus doz 1 mg, kilitli kalma süresi 10 dk. ve limit 50 mg 24 saat-1) verildi. Grup MP’ye (n=30) morfin HKA’ya ek olarak iv parasetamol (1 gr 15 dk. içinde infüzyon, 8 g 48 saat-1) verildi. Ayılma odasına alınan (0. dk.’da) ve Vizüel Analog Skala’sına göre skorları 3’ten büyük olan tüm olgulara fraksiyone dozlarda morfin yapıldı. Postoperatif 0., 30., 60. dk, 2., 4., 6., 12., 18., 24. ve 48. saatlerde sistolik arter basıncı, diyastolik arter basıncı, kalp atım hızı, periferik oksijen satürasyonu, solunum sayısı, hasta kontrollü analjezi istek sayısı, yanıtlanan hasta kontrollü analjezi istek sayısı, sedasyon skorları, VAS skorları, bulantı-kusma, kaşıntı ve döküntü varlığı kaydedildi. Ayrıca, fraksiyone morfin miktarları ve antiemetik tüketimi de kaydedildi. Bulgular: Fraksiyone morfin miktarları, total morfin tüketimi ve sedasyon skorları Grup MP’de daha düşük olarak bulundu (p

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Cite This Article

TURAN, I. Ö., YURTLU, S., GÜL, Ş., AKAY, S., ÖZ, Ö. O., AÇAR, A., AYOĞLU, H. (2022). The effect of peroperatively and postoperatively used parasetamol on postoperative morphine consumption in spinal surgery. Türk Anestezi ve Reanimasyon Dergisi, Cilt: 36 - Sayı: 5, 304–309. https://ajindex.com/articles/619980

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References (14)

  1. Morgan GE, Mikhail MS, Murray MJ (Eds). Clinical Anesthesiology. 3th ed. New York. Lange Medical Books, Mc Graw Hill Company. 2003; 309-58
  2. Mc Cormack K, Brune K. Dissociation between the antinociceptive and anti-inflammatory effects of the nonsteroidal anti-inflammatory drugs: a survey of their analgesic efficacy. Drugs. 1991; 41:533-47
  3. Hernandez-Palazon J, Tortosa JA, Martinez-Lage JF, Perez-Flores D. Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. Anesth Analg 2001; 92:1473-6
  4. Fletcher D, Negre I, Barbin C, et al. Postoperative analgesia with i.v. propacetamol and ketoprofen combination after disc surgery. Can J Anaesth 1997; 44:479-85
  5. Siddik SM, Aouad MT, Jalbout MI, et al. Diclofenac and /or propacetamol for postoperative pain management after cesarean delivery in patients receiving patient controlled analgesia morphine. Reg Anesth Pain Med 2001; 26:310-5
  6. Delbos A, Boccard E. The morphine-sparing effect of propacetamol in orthopedic postoperative pain. J Pain Symptom Manage 1995; 10:279-86
  7. Sinatra RS, Jahr JS, Reynolds LW, et al. Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. Anesthesiology 2005; 102:822-31
  8. Beaussier M, Weickmans H, Paugam C, et al. A randomized, double-blind comparison between parecoxib sodium and propacetamol for parenteral postoperative analgesia after inguinal hernia repair in adult patients. Anesth Analg 2005; 100:1309-15
  9. Balcı C, Karabekir HS, Sıvacı RG, Toprak D, Ela Y, Pancaroğlu M. Lomber Disk cerrahisi yapılan hastalarda postoperatif analjezide lornoksikam ve tramadolün hasta kontrollü analjezi yöntemi ile etkinliklerinin karşılaştırılması. Türk Anest Rean Der Dergisi 2006; 34:228-35
  10. Yücel A. Postoperatif Analjezi, İstanbul: 2004, 7-68 ve 145-57
  11. Ward B, Alexander JM. Paracetamol revisited: A review of the pharmacokinetics and pharmacodynamics. Acute Pain 1999; 2:140-9
  12. Granry JC, Rod B, Monrigal JP, Merckx J, Berniere J, Jean N, Boccard E. The analgesic efficacy of an injectable prodrug of acetaminophen in children after orthopaedic surgery. Paediatr Anaesth 1997; 7:445-9
  13. Çevik B, Sezen Ö, Büyükkırlı H, Bombacı E, Çolakoğlu S. Bupivakain ya da Ropivakain ile İnsizyon Bölgesi İnfiltrasyonunun Postoperatif Analjezi Üzerine Etkileri. Türk Anest Rean Der Dergisi 2005; 33:145-50
  14. Collins VJ. Opiate and