Journals / Turkish Journal of Pharmaceutical Sciences / 2020 / Cilt: 17 - Sayı: 4

Toxicological Evaluation of Bisphenol A and Its Analogues

Bisfenol A ve Analoglarının Toksikolojik Değerlendirilmesi

Pages
457–462
Publication Date
2022-11-03
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

BPS and BPF) which are increasingly used today as alternative to BPA.Key words: Bisphenols, bisphenol A, endocrine disruptor, bisphenol S, bisphenol F

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Bisphenol A (BPA) is known as one of the oldest synthetic compounds with endocrine disrupting activity.
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Key Findings & Data:It is commonly used in the productionof epoxy resins, polycarbonates, dental fillings, food storage containers, baby bottles, and water containers.
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Conclusion & Impact:BPS and BPF) which are increasingly used today as alternative to BPA.Key words: Bisphenols, bisphenol A, endocrine disruptor, bisphenol S, bisphenol F
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Bisphenol A (BPA) is known as one of the oldest synthetic compounds with endocrine disrupting activity. It is commonly used in the productionof epoxy resins, polycarbonates, dental fillings, food storage containers, baby bottles, and water containers. BPA is associated with various healthproblems such as obesity, diabetes, chronic respiratory diseases, cardiovascular diseases, renal diseases, behavior disorders, breast cancer, toothdevelopment disorders, and reproductive disorders. Increasing health concerns have led the industry to seek alternatives to BPA. As BPA is nowbeing excluded from several consumer products, the use of alternative compounds is increasing. However, the chemicals used to replace BPA arealso BP analogues and may have similar or higher toxicological effects on organisms. The aim of this review is to focus on the toxicological profilesof different BP analogues (i.e. BPS and BPF) which are increasingly used today as alternative to BPA.Key words: Bisphenols, bisphenol A, endocrine disruptor, bisphenol S, bisphenol F

Özet

Bisfenol A (BPA) endokrin aktiviteye sahip bilinen en eski bileşiklerden biridir. BPA epoksi reçineler, polikarbonatlar, diş dolguları, yemek saklama kapları, bebek biberonları ve su bidonlarının üretiminde yaygın olarak kullanılmaktadır. BPA obezite, diyabet, kronik solunum hastalıkları, kardiyovasküler hastalıklar, renal hastalıklar, davranış bozuklukları, meme kanseri, diş gelişimi bozuklukları ve üreme bozuklukları gibi çeşitli sağlık sorunlarıyla ilişkilendirilmiştir. Artan sağlık endişeleri endüstriyi BPA alternatifleri aramaya yönlendirmiştir. Günümüzde BPA tüketici ürünlerinden çıkarılmaya başlandığı için, alternatif bileşiklerin kullanımı artmaktadır. Ancak, BPA yerine kullanılan kimyasallar da BP analoglarıdır ve organizmalar üzerinde benzer toksikolojik etkileri olabilir. Bu derlemenin amacı günümüzde BPA’ya artan miktarlarda alternatif olarak kullanılan BP analoglarının (BPS ve BPF) toksikolojik profillerine odaklanmaktadır.

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Cite This Article

ÜSTÜNDAĞ, A., İYİGÜNDOĞDU, İ., DUYDU, Y. (2022). Toxicological Evaluation of Bisphenol A and Its Analogues. Turkish Journal of Pharmaceutical Sciences, Cilt: 17 - Sayı: 4, 457–462. https://ajindex.com/articles/613721

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