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Journals / Turkish Journal of Pharmaceutical Sciences / 2014 / Cilt: 11 - Sayı: 2

Hiperbarik Oksijen Tedavisinin (HBOT) Sebep Olduğu Genotoksik Etkilerin İncelenmesi

Evaluation of the Genotoxic Effects of Patients Undergoing Hyperbaric Oxygen (HBO) Therapy

AYLİN ÜSTÜNDAĞ
Kemal ŞİMŞEK
Hakan Ay
Kadir DÜNDAR
HALİT SİNAN SÜZEN
Ahmet AYDIN
Yalçın DUYDU
Pages
203–208
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the MN test results, it is observed that HBO treatment can increase the clastogenic effects

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hyperbaric oxygen (HBO) therapy is successfully applied for a wide variety of diseases.
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Key Findings & Data:Blood samples were obtained from 100 voluntary patients and were drawn by venipuncture before and immediately after the first session of HBO treatment.
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Conclusion & Impact:According to the MN test results, it is observed that HBO treatment can increase the clastogenic effects
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Hyperbaric oxygen (HBO) therapy is successfully applied for a wide variety of diseases. However, recent studies in humans undergoing hyperbaric oxygen (HBO) therapy have revealed that HBO is able to induce genotoxic effects especially in lymphocytes while the biological significance of this outcome is still not clear. HBO mediated genotoxicity in lymphocytes has been determined by using the in vitro Cytokinesis Block Micronucleus (MN) test in patients undergoing HBO therapy. Blood samples were obtained from 100 voluntary patients and were drawn by venipuncture before and immediately after the first session of HBO treatment. MN frequencies were significantly increased after the first session of HBO treatment. According to the MN test results, it is observed that HBO treatment can increase the clastogenic effects

Özet

HBOT günümüzde pek çok farklı alanda uygulama alanı bulabilen modern bir tedavi yöntemi olarak karşımıza çıkmaktadır. Son yıllarda bu tedavi yöntemi ile ilgili olarak yapılan HBOT'nin özellikle lenfositlerde sebep olduğu genotoksik etkilerin araştırıldığı pek çok çalışma bulunmaktadır. Bu çalışmanın amacı HBOT uygulandıktan sonra oluşabilecek genotoksik hasarın Sitokinezi Bloke Edilmiş Mikroçekirdek (MN) testi kullanılarak değerlendirilmesidir. Bu amaçla HBO tedavisi uygulanan 100 gönüllü hastadan tedaviye başlamadan önce ve ilk tedavi seansının hemen sonrasında kan numunesi alınmıştır. HBO tedavisinin ilk seansının mikroçekirdek frekanslarını artırdığı gözlenmiştir. MN testi sonuçlarına göre, HBO tedavisinin hastalarda klastojenik etkileri arttırabildiği görülmüştür

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Cite This Article

ÜSTÜNDAĞ, A., ŞİMŞEK, K., Ay, H., DÜNDAR, K., SÜZEN, H. S., AYDIN, A., DUYDU, Y. (2014). Hiperbarik Oksijen Tedavisinin (HBOT) Sebep Olduğu Genotoksik Etkilerin İncelenmesi. Turkish Journal of Pharmaceutical Sciences, Cilt: 11 - Sayı: 2, 203–208. https://ajindex.com/articles/404004

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