In the cytotoxic evaluation, betulinic acid, the major component, showed good cytotoxic activity against all tested cancer cell lines while new compound 1 was weakly active.
📌 3 Key Takeaways
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Objective & Hypothesis:Phytochemical study of Adinandra hainanensis stems led to the isolation of a new triterpene lupan-3β,20- dihydroxy-28-carbaldehyde (1) and eleven known compounds 2-12.
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Key Findings & Data:The stems of A. hainanensis was rich in lupanetype triterpenes, especially betulinic acid (9) was abundant (around 0.45% w/w).
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Conclusion & Impact:In the cytotoxic evaluation, betulinic acid, the major component, showed good cytotoxic activity against all tested cancer cell lines while new compound 1 was weakly active.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Phytochemical study of Adinandra hainanensis stems led to the isolation of a new triterpene lupan-3β,20- dihydroxy-28-carbaldehyde (1) and eleven known compounds 2-12. The stems of A. hainanensis was rich in lupanetype triterpenes, especially betulinic acid (9) was abundant (around 0.45% w/w). The isolated triterpenes, including new compound 1 showed strong α-glucosidase inhibitory activity with IC50 values ranging of 2.27 ± 0.05 μg/mL to 12.25 ± 0.36 μg/mL. In the cytotoxic evaluation, betulinic acid, the major component, showed good cytotoxic activity against all tested cancer cell lines while new compound 1 was weakly active.
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Cite This Article
THANH, L. N., OANH, V. T. K., BUI, T. H., DIEP, T. L. P., NGUYEN, T. V. A., GİAP, T. H. (2022). Chemical Constituents and Biological Activity of the Stems of Adinandra hainanensis Hayata. Records of Natural Products, Cilt: 16 - Sayı: 4, 346–352. https://ajindex.com/articles/588763
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