Three Isoflavonoid Glycosides from the Rhizomes of Achyranthes bidentata and their Protective Effects on H2O2 Induced H9c2 Cardiomyocytes Injury

Bioassay results showed all the three compounds had obviously cell-protective effects against H2O2-induced H9c2 cardiomyocytes injury in a concentration -dependent manner.

📌 3 Key Takeaways

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Objective & Hypothesis:A new isoflavonoid glycoside, achyranthoside C (1), along with two known compounds (2 and 3) were isolated from the rhizomes of Achyranthes bidentata.

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Key Findings & Data:Compounds 1-2 were two rare natural isoflavonoid glycosides with C8 hydroxymethylene derivatization.

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Conclusion & Impact:Bioassay results showed all the three compounds had obviously cell-protective effects against H2O2-induced H9c2 cardiomyocytes injury in a concentration -dependent manner.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

A new isoflavonoid glycoside, achyranthoside C (1), along with two known compounds (2 and 3) were isolated from the rhizomes of Achyranthes bidentata. Compounds 1-2 were two rare natural isoflavonoid glycosides with C8 hydroxymethylene derivatization. Their structures were elucidated through comprehensive 1D and 2D NMR, UV, IR, and HRMS analyses. Bioassay results showed all the three compounds had obviously cell-protective effects against H2O2-induced H9c2 cardiomyocytes injury in a concentration -dependent manner.

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Cite This Article

Lİ, Y., CHİ, J., WANG, P., ZHANG, L., Lİ, Q., FENG, Q., DAİ, L., WANG, Z. (2022). Three Isoflavonoid Glycosides from the Rhizomes of Achyranthes bidentata and their Protective Effects on H2O2 Induced H9c2 Cardiomyocytes Injury. Records of Natural Products, Cilt: 16 - Sayı: 2, 110–117. https://ajindex.com/articles/588750

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