The results showed that all the monoester-type C19-diterpenoid alkaloids exhibited cardiotoxicity, and compound 6 was found to be the most toxic compound.
📌 3 Key Takeaways
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Objective & Hypothesis:A new (1) and six known (2-7) monoester-type C19-diterpenoid alkaloids were isolated from the lateral roots of Aconitum carmichaelii Debx.
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Key Findings & Data:Compound 1 (1-epi-hokbusine A) was an aconitine-type diterpenoid alkaloid possessing an unusual 1β-methoxy group.
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Conclusion & Impact:The results showed that all the monoester-type C19-diterpenoid alkaloids exhibited cardiotoxicity, and compound 6 was found to be the most toxic compound.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
A new (1) and six known (2-7) monoester-type C19-diterpenoid alkaloids were isolated from the lateral roots of Aconitum carmichaelii Debx. Their structures were determined by spectroscopic techniques and calculations of NMR chemical shifts. Compound 1 (1-epi-hokbusine A) was an aconitine-type diterpenoid alkaloid possessing an unusual 1β-methoxy group. According to the main toxicity of the lateral roots of A. carmichaelii, the cardiotoxic effects of the isolates were evaluated using H9c2 rat myocardial cells and zebrafish embryos. The results showed that all the monoester-type C19-diterpenoid alkaloids exhibited cardiotoxicity, and compound 6 was found to be the most toxic compound.
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Cite This Article
LIN, Q., ZHOU, Q., MENG, C., LIU, J., DAI, O., PENG, C., DING, X., MIAO, L., WANG, X. (2022). Monoester-Type C19-Diterpenoid Alkaloids from Aconitum carmichaelii and Their Cardiotoxicity. Records of Natural Products, Cilt: 16 - Sayı: 4, 324–334. https://ajindex.com/articles/588746
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