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Journals / Journal of Turkish Spinal Surgery / 2021 / Cilt: 32 - Sayı: 4

EVALUATION OF SERUM THIOL/DISULFIDE HOMEOSTASIS AND ISCHEMIA-MODIFIED ALBUMIN LEVELS IN LUMBAR DISC HERNIATION

Özcan EREL
Esra Fırat OĞUZ
Ahmet Eren SEÇEN
Denizhan DİVANOĞLU
Ali DALGIÇ
Özgür ÖCAL
Zeynep DAĞLAR
Göksal GÜNERHAN
Pages
139–143
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: LDH influences the thiol-disulfide balance, and increased IMA levels can predict LDH.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Lumbar disc herniation (LDH) is a socio-economic burden.
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Key Findings & Data:Materials and Methods: This prospective case-control study included 30 patients with LDH and a control group with 30 healthy volunteers.
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Conclusion & Impact:Conclusion: LDH influences the thiol-disulfide balance, and increased IMA levels can predict LDH.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Lumbar disc herniation (LDH) is a socio-economic burden. The physiopathology of the disease is not clarified completely. This study aimed to investigate the oxidation-reduction balance in LDH via serum thiol-disulfide and ischemia-modified albumin (IMA) levels. Materials and Methods: This prospective case-control study included 30 patients with LDH and a control group with 30 healthy volunteers. Blood samples were analyzed for total thiol (-SH+ -S-S-), native thiol (-SH), and IMA levels. Disulfide levels and native thiol/total thiol ratio were calculated. The results of the two groups were compared. Results: Native and total thiol levels were significantly higher in the LDH group than in the control group (p=0.007 and p=0.008, respectively). IMA levels were significantly higher in the LDH group than in the control group (p=0.000). The receiver operating characteristic curve demonstrated that the IMA value of 1.41 could predict the LDH with 80% sensitivity and 80% specificity (area under curve=0.888, confidence interval: 0.802- 0.974). Conclusion: LDH influences the thiol-disulfide balance, and increased IMA levels can predict LDH.

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Cite This Article

EREL, Ö., OĞUZ, E. F., SEÇEN, A. E., DİVANOĞLU, D., DALGIÇ, A., ÖCAL, Ö., DAĞLAR, Z., GÜNERHAN, G. (2022). EVALUATION OF SERUM THIOL/DISULFIDE HOMEOSTASIS AND ISCHEMIA-MODIFIED ALBUMIN LEVELS IN LUMBAR DISC HERNIATION. Journal of Turkish Spinal Surgery, Cilt: 32 - Sayı: 4, 139–143. https://ajindex.com/articles/568571

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References (13)

  1. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis fort he global burden of disease study 2010. Lancet. 2012;380:2163-96
  2. Jordan J, Konstantinou K, O’Dowd J. Herniated lumbar disc. BMJ Clin Evid. 2011;2011:1118
  3. Cong L, Zhu Y and Tu G. A meta-analysis of endoscopic discectomy versus open discectomy for symptomatic lumbar disk herniation. Eur Spine J. 2016;25:134-43
  4. Jha SC, Tonogai I, Takata Y, Sakai T, Higashino K, Matsuura T, et al. Percutaneous endoscopic lumbar discectomy for a huge herniated disc causing acute cauda equina syndrome: A case report. J Med Invest. 2015;62:100-2
  5. Wang SJ, Chen BH, Wang P, Liu CS, Yu JM, Ma XX. The effect of percutaneous endoscopic lumbar discectomy under different anesthesia on pain and immunity of patients with prolapse of lumbar intervertebral disc. Eur Rev Med Pharmacol Sci. 2017;21:2793-9
  6. Hou G, Lu H, Chen M, Yao H, Zhao H. Oxidative stress participates in age-related changes in rat lumbar intervertebral discs. Arch Gerontol Geriatr. 2014;59:665-9
  7. Chen JW, Ni BB, Li B, Yang YH, Jiang SD, Jiang LS. The responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells: Implications for disc degeneration. Cell Physiol Biochem. 2014;34:1175-89
  8. Wang H, Song Y, Cai L. Effect of percutaneous transforaminal lumbar spine endoscopic discectomy on lumbar disc herniation and its influence on indexes of oxidative stress. Biomed Res. 2017;28:9464-9
  9. Suzuki S, Fujita N, Hosogane N, Watanabe K, Ishii K, Toyama Y, et al. Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration. Arthritis Res Ther. 2015;17:316
  10. Dimozi A, Mavrogonatou E, Sklirou A, Kletsas D. Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells. Eur Cell Mater. 2015;30:89-102; discussion 103
  11. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem. 2014;47:326-32
  12. Erol SA, Tanacan A, Altinboga O, Ozturk FH, Ozgu BS, Tasci Y, et al. Evaluation of fetal serum thiol/disulfide homeostasis and ıschemiamodified albumin levels in fetal Distress. Fetal Pediatr Pathol. 2020:1-10
  13. Liu Y, Lin J, Wu X, Guo X, Sun H, Yu B, et al. Aspirin-mediated attenuation of ıntervertebral disc degeneration by amelioratin