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Dergiler / Journal of Turkish Spinal Surgery / 2021 / Cilt: 32 - Sayı: 4

EVALUATION OF SERUM THIOL/DISULFIDE HOMEOSTASIS AND ISCHEMIA-MODIFIED ALBUMIN LEVELS IN LUMBAR DISC HERNIATION

Özcan EREL
Esra Fırat OĞUZ
Ahmet Eren SEÇEN
Denizhan DİVANOĞLU
Ali DALGIÇ
Özgür ÖCAL
Zeynep DAĞLAR
Göksal GÜNERHAN
Sayfa
139–143
Yayın Tarihi
2022-10-18
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: LDH influences the thiol-disulfide balance, and increased IMA levels can predict LDH.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Lumbar disc herniation (LDH) is a socio-economic burden.
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Temel Bulgular & Veri:Materials and Methods: This prospective case-control study included 30 patients with LDH and a control group with 30 healthy volunteers.
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Sonuç & Katkı:Conclusion: LDH influences the thiol-disulfide balance, and increased IMA levels can predict LDH.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Objective: Lumbar disc herniation (LDH) is a socio-economic burden. The physiopathology of the disease is not clarified completely. This study aimed to investigate the oxidation-reduction balance in LDH via serum thiol-disulfide and ischemia-modified albumin (IMA) levels. Materials and Methods: This prospective case-control study included 30 patients with LDH and a control group with 30 healthy volunteers. Blood samples were analyzed for total thiol (-SH+ -S-S-), native thiol (-SH), and IMA levels. Disulfide levels and native thiol/total thiol ratio were calculated. The results of the two groups were compared. Results: Native and total thiol levels were significantly higher in the LDH group than in the control group (p=0.007 and p=0.008, respectively). IMA levels were significantly higher in the LDH group than in the control group (p=0.000). The receiver operating characteristic curve demonstrated that the IMA value of 1.41 could predict the LDH with 80% sensitivity and 80% specificity (area under curve=0.888, confidence interval: 0.802- 0.974). Conclusion: LDH influences the thiol-disulfide balance, and increased IMA levels can predict LDH.

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Bu Makaleye Atıf Yap

EREL, Ö., OĞUZ, E. F., SEÇEN, A. E., DİVANOĞLU, D., DALGIÇ, A., ÖCAL, Ö., DAĞLAR, Z., GÜNERHAN, G. (2022). EVALUATION OF SERUM THIOL/DISULFIDE HOMEOSTASIS AND ISCHEMIA-MODIFIED ALBUMIN LEVELS IN LUMBAR DISC HERNIATION. Journal of Turkish Spinal Surgery, Cilt: 32 - Sayı: 4, 139–143. https://ajindex.com/articles/568571

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Kaynakça (13)

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