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Journals / BEYOGLU EYE JOURNAL / 2020 / Cilt: 5 - Sayı: 3

Assessment of Plasma Thiol-disulfide Balance in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Tamer Takmaz
Derya YAMAN
Ni̇lay YÜKSEL
Mücella Arıkan YORGUN
Almila ŞENAT
Özcan EREL
Pages
214–218
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Statistically significant differences were observed in the plasma disulfide levels (21.6±7.3 μmol/L vs. 17.4±6.8 μmol/L) and the native thiol/disulfide ratio (22.9±9.1 vs. 29.9±14.7) between the PEXG group and the controls (p=0.03, p=0.02, respectively).Conclusion: Significant differences in the plasma levels of disulfide and the native thiol/disulfide ratio in PEXG patients indicated a breakdown of the thiol-disulfide circuits.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: The thiol-disulfide balance is very important in cellular events such as apoptosis and oxidative stress.
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Key Findings & Data:This study is a comparison of plasma thiol-disulfide homeostasis in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).Methods: Thirty-one patients with PEXS, 43 patients with PEXG, and 38 healthy controls were included in this prospec-tive study.
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Conclusion & Impact:Statistically significant differences were observed in the plasma disulfide levels (21.6±7.3 μmol/L vs. 17.4±6.8 μmol/L) and the native thiol/disulfide ratio (22.9±9.1 vs. 29.9±14.7) between the PEXG group and the controls (p=0.03, p=0.02, respectively).Conclusion: Significant differences in the plasma levels of disulfide and the native thiol/disulfide ratio in PEXG patients indicated a breakdown of the thiol-disulfide circuits.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: The thiol-disulfide balance is very important in cellular events such as apoptosis and oxidative stress. This study is a comparison of plasma thiol-disulfide homeostasis in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).Methods: Thirty-one patients with PEXS, 43 patients with PEXG, and 38 healthy controls were included in this prospec-tive study. The plasma level of native thiol and disulfide were measured using a spectrophotometric assay and the native thiol/disulfide ratio was analyzed.Results: The demographic characteristics of the 3 groups were similar (p>0.05). Statistically significant differences were observed in the plasma disulfide levels (21.6±7.3 μmol/L vs. 17.4±6.8 μmol/L) and the native thiol/disulfide ratio (22.9±9.1 vs. 29.9±14.7) between the PEXG group and the controls (p=0.03, p=0.02, respectively).Conclusion: Significant differences in the plasma levels of disulfide and the native thiol/disulfide ratio in PEXG patients indicated a breakdown of the thiol-disulfide circuits.

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Cite This Article

Takmaz, T., YAMAN, D., YÜKSEL, N., YORGUN, M. A., ŞENAT, A., EREL, Ö. (2020). Assessment of Plasma Thiol-disulfide Balance in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. BEYOGLU EYE JOURNAL, Cilt: 5 - Sayı: 3, 214–218. https://ajindex.com/articles/353105

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References (15)

  1. Schlötzer-Schrehardt UM, Koca MR, Naumann GO, Volkholz H. Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder? Arch Ophthalmol 1992;110:1752–6
  2. Naumann GO, Schlötzer-Schrehardt U, Küchle M. Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations. Ophthalmology 1998;105:951–68
  3. Gartaganis SP, Georgakopoulos CD, Patsoukis NE, Gotsis SS, Gartaganis VS, Georgiou CD. Glutathione and lipid peroxide changes in pseudoexfoliation syndrome. Curr Eye Res 2005;30:647–51
  4. Erdurmuş M, Yağcı R, Atış Ö, Karadağ R, Akbaş A, Hepşen IF. Antioxidant status and oxidative stress in primary open angle glaucoma and pseudoexfoliative glaucoma. Curr Eye Res 2011;36:713–8
  5. Yağci R, Gürel A, Ersöz I, Keskin UC, Hepşen IF, Duman S, et al. Oxidative stress and protein oxidation in pseudoexfoliation syndrome. Curr Eye Res 2006;31:1029–32
  6. Yilmaz A, Adigüzel U, Tamer L, Yildirim O, Oz O, Vatansever H, et al. Serum oxidant/antioxidant balance in exfoliation syndrome. Clin Exp Ophthalmol 2005;33:63–6
  7. Schlötzer-Schrehardt U, Naumann GO. Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol 2006;141:921– 37
  8. Netland PA, Ye H, Streeten BW, Hernandez MR. Elastosis of the lamina cribrosa in pseudoexfoliation syndrome with glaucoma. Ophthalmology 1995;102:878–86
  9. Alvarado JA, Murphy CG. Outflow obstruction in pigmentary and primary open angle glaucome. Arch Ophthalmol 1992;110:1769–78
  10. Lütjen-Drecoll E, Shimizu T, Rohrbach M, Rohen JW. Quantitative analysis of 'plaque material' in the inner- and outer wall of Schlemm's canal in normal- and glaucomatous eyes. Exp Eye Res 1986;42:443–55
  11. Izzotti A, Bagnis A, Sacca SC. The role of oxidative stress in glaucoma. Mutat Res 2000;612:104–5
  12. Tezel G. Oxidative stress in glaucomatous neurodegeneration: mechanisms and consequences. Prog Retin Eye Res 2006;25:490–513
  13. Koliakos GG, Befani CD, Mikropoulos D, Ziakas NG, Konstas AG. Prooxidant-antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma. Graefes Arch Clin Exp Ophthalmol 2008;246:1477–83
  14. Schlötzer-Schrehardt U, Lommatzsch J, Küchle M, Konstas AG, Naumann GO. Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/ glaucoma and primary open-angle glaucoma. Invest Ophthalmol Vis Sci 2003;44:1117–25
  15. Biswas S, Chida AS, Rahman I. Red