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Journals / Journal of Neurological Sciences (Turkish) / 2014 / Cilt: 31 - Sayı: 4

Moyamoya Hastalığı ile Tiroid Fonksiyonları ve Tiroid Otoantikorlarının Birlikteliği: Batı Çin de İleriye Dönük Bir Çalışma

Association of Thyroid Autoantibodies and Thyroid Function with Moyamoya Disease: a prospective study in Western China

Chao YOU
Jian-bin CHEN
Ding LEI
Min HE
Liang-xue ZHOU
Hong SUN
Pages
709–717
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Theprevalence of elevated thyroid autoantibodies (p < 0.001) and increased thyroid function (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to further investigate whether elevated thyroidautoantibodies and increased thyroid function associated with moyamoya disease (MMD).Methods: We prospectively studied angiographically identified patients with idiopathicMMD and compared clinical characteristics, serum thyroid autoantibodies and thyroidhormones levels, T cell subsets between MMD patients and healthy controls by employing a1:1 case-control study design.
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Key Findings & Data:We assessed the disease progressions of MMD patientsassociated with thyroid autoimmune disease.Results: A total of 52 patients with MMD and 52 healthy controls were included.
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Conclusion & Impact:Theprevalence of elevated thyroid autoantibodies (p < 0.001) and increased thyroid function (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to further investigate whether elevated thyroidautoantibodies and increased thyroid function associated with moyamoya disease (MMD).Methods: We prospectively studied angiographically identified patients with idiopathicMMD and compared clinical characteristics, serum thyroid autoantibodies and thyroidhormones levels, T cell subsets between MMD patients and healthy controls by employing a1:1 case-control study design. We assessed the disease progressions of MMD patientsassociated with thyroid autoimmune disease.Results: A total of 52 patients with MMD and 52 healthy controls were included. Theprevalence of elevated thyroid autoantibodies (p < 0.001) and increased thyroid function (p

Özet

Amaç: Bu çalışmanın amacı artmış tiroid fonksiyonları ile artmış tiroid otoantikorlarınınMoyamoya hastalığındaki (MMH) birlikteliğini derinliğine araştırmaktır. Yöntem: Anjiograjik olarak kanıtlanmış idyopatik MMH olan olgularda ileriye dönük olarakklinik özellikleri, serum tiroid otoantikorları, tiroid hormon seviyeleri, T hücresi alt-grupları1:1 olgu-kontrol çalışma düzeninde sağlıklı normallerle karşılaştırılarak çalışıldı. MMHolgularının tiroid otoimmün hastalığı ile birlikte olanların hastalık progresyonlarınıdeğerlendirdik.Sonuçlar: Çalışmaya toplam olarak 52 MMH ve 52 sağlıklı kontrol dahil edildi. Sağlıklıkontrollere göre MMH olgularında tiroid otoantikor (p < 0,001) ve tiroid hormon seviyeleri(p < 0,001) önemli ölçüde yüksek prevalansta bulundu. Yardımcı değişkenlerin de uyumusonrası hem yüksek tiroid otoantikorları (OR, 6,41; %95 CI, 1,24-33,24; p = 0,027) hem deartmış tiroid fonksiyonları (OR, 12,11;%95 CI, 1,39-105,74; p = 0,024) önemli ölçüde MMH gelişiminde katkısı saptandı. MMH olgularının antitiroid tedavileri sonrası Suzukievrelemesinde önemli ölçüde daha az progresyon gösterdiler (p = 0,011 her ikisi için).Yargı: Bu bulgular göstermektedir ki MMH ile altında yatan tiroid otoimmün bozukluklarıbirliktedir. Antitiroid tedavisi MMH ile tiroid hastalığının birlikte olduğu olgularda durumudüzeltmede yararlı olacaktır.

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Cite This Article

YOU, C., CHEN, J., LEI, D., HE, M., ZHOU, L., SUN, H. (2022). Moyamoya Hastalığı ile Tiroid Fonksiyonları ve Tiroid Otoantikorlarının Birlikteliği: Batı Çin de İleriye Dönük Bir Çalışma. Journal of Neurological Sciences (Turkish), Cilt: 31 - Sayı: 4, 709–717. https://ajindex.com/articles/565033

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