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Journals / Journal of Neurological Sciences (Turkish) / 2012 / Cilt: 29 - Sayı: 1

Evidence-Based Treatment of Primary and Recurrent Brain Metastasis

Birincil ve Rekürren Metastatik Beyin Tümörlerinin Kanıta Dayalı Tedavisi

Tayfun HAKAN
Pages
171–178
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Repeated resection of the recurrent tumors isrecommended in suitable patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Brain metastases are the most common tumors of central nervous system.
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Key Findings & Data:The main treatmentof these tumors includes surgical resection, radiotherapy and chemotherapy.
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Conclusion & Impact:Repeated resection of the recurrent tumors isrecommended in suitable patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Brain metastases are the most common tumors of central nervous system. The main treatmentof these tumors includes surgical resection, radiotherapy and chemotherapy. There are class Ievidences supporting that the combination of surgical resection and whole brain radiationtherapy is better than the other modalities. However, all these are not sufficient to preventrecurrences. It is said that one of the main cause of the recurrences of brain metastases is theinfiltration of the tumor cells into the periglial tissue. For these, en block resection withperitumoral tissue is advised for primary brain metastasis in available cases by some authors.There is no consensus for treatment of these recurrent brain tumors. There is no evidencebased treatment guideline for these tumors either. The clinical condition of the patient, theclinical findings of the recuurent tumor, the aim of the palliation in the patient, the symptomthat require treatment in the patient are the subjects should be considered for making decisionof treatment of the recurrent brain tumors. Repeated resection of the recurrent tumors isrecommended in suitable patients.

Özet

Beyin metastazları en sık görülen SSS tümörleridir. Metastatik beyin tümörlerinin tedavisiasıl olarak cerrahi rezeksiyon, ışın tedavisi, kemoterapi ve kombine tedaviler şeklindedir.Yeni saptanan beyin metastazlarında tedavinin cerrahi rezeksiyon ve ek olarak tüm beyin ışıntedavisi uygulamasının iyi sonuçlar verdiğine dair sınıf I kanıtlar bulunmaktadır. Ancak, tümbu tedavilere karşın hastalar yeterince uzun yaşarlarsa bu tümörler nüks etmektedir.Tümörlerin tekrarlamasında en büyük etkenin tümör hücrelerinin peritümöral glial dokuiçinde infiltrasyon yapmaları gösterilmektedir. Tekrar eden bu tümörlerin tedavisi konusundabir uzlaşma yoktur. Bu konuda kanıta dayalı bir tedavi şeması bulunmamaktadır. Tekrarlayanbeyin metastazlarında tedavinin hastanın klinik durumu, tekrarlayan tümörün klinik etkisi,hastada amaçlanan palyasyonun ne olduğu, hastadaki hangi semptomun giderileceği gözönüne alınarak karar verilmelidir.

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Cite This Article

HAKAN, T. (2022). Evidence-Based Treatment of Primary and Recurrent Brain Metastasis. Journal of Neurological Sciences (Turkish), Cilt: 29 - Sayı: 1, 171–178. https://ajindex.com/articles/565715

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