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Journals / Journal of Clinical and Analytical Medicine / 2013 / Cilt: 4 - Sayı: 5

Artritten kansere çok fonksiyonlu bir gen ailesi: Trombospondin motifli disintegrin benzeri Matriks metalloproteinazlar

A multi-functional gene family from arthritis to cancer: A disintegrin-like metalloproteinase with thrombospondin type-1 Motif (ADAMTS)

Ferah ARMUTCU
Kadir DEMİRCAN
Sümeyya AKYOL
Pages
429–434
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Especially, understanding of the ADAMTSs roles in the pathogenesis of diseases may lead new diagnostic approaches and development of specific therapeutic agents.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A Disintegrin-like and Metalloproteinase with Trombospondin type-1 motif (ADAMTS) genes were first discovered in 1997.
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Key Findings & Data:Currently 19 mammalian ADAMTS proteainases have identified.
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Conclusion & Impact:Especially, understanding of the ADAMTSs roles in the pathogenesis of diseases may lead new diagnostic approaches and development of specific therapeutic agents.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A Disintegrin-like and Metalloproteinase with Trombospondin type-1 motif (ADAMTS) genes were first discovered in 1997. Currently 19 mammalian ADAMTS proteainases have identified. As a member of matrix metallopro- teinases, ADAMTS play a critical role in the degradation/repairing of extracellular matrix. Recent studies demonstrated that ADAMTSs were likely tobe useful in understanding of many disease pathogenesis such as arthritis, liver fibrosis and cancer. Therefore, it is important to understand molecular organization and function of ADAMTSs. The objective of this review is to assist the better understanding of the structure, function and contributions of ADAMTSs on the related disease pathogenesis. Especially, understanding of the ADAMTSs roles in the pathogenesis of diseases may lead new diagnostic approaches and development of specific therapeutic agents.

Özet

A Disintegrin-like and Metalloproteinase with Trombospondin type-1 motifADAMTS) genleri 1997 yılında keşfedildi. Şimdiye kadar 19 farklı memeliADAMTS proteinazı tanımlandı. Matriks metalloproteinaz ailesinin üyesi olanADAMTS’ler hücre dışı makriksin yıkım ve onarımında önemli görevlere sahiptirler. Son zamanlarda yapılan çalışmalar ADAMTS’lerin; artrit, karaciğerfibrozu ve kanser gibi pek çok hastalığın patogenezinde kritik olduğunu göstermektedir. Bu nedenle ADAMTS’lerin moleküler organizasyonu ve fonksiyonunun anlaşılması önem kazanmaktadır. Bu derlemenin amacı, ADAMTS’lerinyapısının, görevlerinin ve ilişkili olduğu hastalıkların patogenezine olan katkılarının daha iyi anlaşılmasına yardımcı olmaktır. Özellikle hastalıklardaki rollerinin ortaya çıkarılması ile ADAMTS’ler tanı için yeni yaklaşımların ve özgünterapötik ajanların geliştirilmesine katkı sağlayabilecektir.

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Cite This Article

ARMUTCU, F., DEMİRCAN, K., AKYOL, S. (2022). Artritten kansere çok fonksiyonlu bir gen ailesi: Trombospondin motifli disintegrin benzeri Matriks metalloproteinazlar. Journal of Clinical and Analytical Medicine, Cilt: 4 - Sayı: 5, 429–434. https://ajindex.com/articles/561237

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References (14)

  1. Kuno K, Kanada N, Nakashima E, Fujiki F, Ichimura F, Matsushima K. Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem 1997;272(1):556-62
  2. Apte SS. A disintegrin-like and metalloprotease (reprolysin-type) with throm- bospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. J Biol Chem 2009;284(46):31493-7
  3. Jungers KA, Le Goff C, Somerville RP, Apte SS. Adamts9 is widely expressed during mouse embryo development. Gene Expr Patterns 2005;5(5):609-17
  4. Tortorella MD, Malfait F, Barve RA, Shieh HS, Malfait AM. A review of the ADAMTS family pharmaceutical targets of the future. Curr Pharm Des 2009;15(20):2359-74
  5. Nagase H, Kashiwagi M. Aggrecanases and cartilage matrix degradation. Art- hritis Res Ther 2003;5(2):94-103
  6. Levy GG, Motto DG, Ginsburg D. ADAMTS13 turns 3. Blood 2005; 106(1): 11-7
  7. Hatipoglu OF, Hirohata S, Cilek MZ, Ogawa H, Miyoshi H, Obika M, et al. ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells. J Biol Chem 2009;284(24):16325-33
  8. Nakamura K, Hirohata S, Murakami T, Miyoshi T, Demircan K, Oohashi T, et al. Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction. J Biochem 2004;136(4):439-46
  9. Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, et al. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J Biol Chem 1999;274(33):23349- 57
  10. Wagsater D, Bjork H, Zhu C, Bjorkegren J, Valen G, Hamsten A, et al. ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. Atherosclerosis 2008;196(2):514-22
  11. Fosang AJ, Little CB. Drug insight: aggrecanases as therapeutic targets for os- teoarthritis. Nat Clin Pract 2008;4: 420-7
  12. Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, et al. Purifica- tion and cloning of aggrecanase-1: A member of the ADAMTS family of proteins. Science 1999;284(5420):1664-6
  13. Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 2005;434(7033):648-52
  14. Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoart- hritis. Nature 2005;434(7033):644-8.