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Journals / Turkish Journal of Medical Sciences / 2013 / Cilt: 43 - Sayı: 1

The effects of formaldehyde intoxication on the inducible nitric oxide synthase expression and nitric oxide level in the liver tissue of rats

Ferah ARMUTCU
Ergün UÇMAKLI
Alaattin ÖZTÜRK
Pages
52–56
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: FA increased iNOS expression and NO production in liver tissue of rats.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats.
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Key Findings & Data:Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt).
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Conclusion & Impact:Conclusion: FA increased iNOS expression and NO production in liver tissue of rats.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Formaldehyde · nitric oxide · iNOS

Abstract

To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats. Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt). The FAt group received intraperitoneal injection of 10 mg/kg FA for 10 days. Activity of iNOS was shown with immunohistochemical stain kits, and the concentration of NO level was measured by spectrophotometric method in the liver tissue. Results: The FAt group had increased iNOS expression and NO levels in liver tissue compared to controls. Conclusion: FA increased iNOS expression and NO production in liver tissue of rats.

Özet

To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats. Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt). The FAt group received intraperitoneal injection of 10 mg/kg FA for 10 days. Activity of iNOS was shown with immunohistochemical stain kits, and the concentration of NO level was measured by spectrophotometric method in the liver tissue. Results: The FAt group had increased iNOS expression and NO levels in liver tissue compared to controls. Conclusion: FA increased iNOS expression and NO production in liver tissue of rats.

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Cite This Article

ARMUTCU, F., UÇMAKLI, E., ÖZTÜRK, A. (2022). The effects of formaldehyde intoxication on the inducible nitric oxide synthase expression and nitric oxide level in the liver tissue of rats. Turkish Journal of Medical Sciences, Cilt: 43 - Sayı: 1, 52–56. https://ajindex.com/articles/611016

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